Neuregulin 2

Neuregulin 2, also known as NRG2, is a protein which in humans is encoded by the NRG2 gene.[5][6][7]

NRG2
Identifiers
AliasesNRG2, DON1, HRG2, NTAK, neuregulin 2
External IDsOMIM: 603818 MGI: 1098246 HomoloGene: 75024 GeneCards: NRG2
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q31.2Start139,846,779 bp[1]
End140,043,299 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9542

100042150

Ensembl

ENSG00000158458

ENSMUSG00000060275

UniProt

O14511

P56974

RefSeq (mRNA)

NM_001167891
NM_001382420

RefSeq (protein)

NP_001171864
NP_004874
NP_053584
NP_053585
NP_053586

n/a

Location (UCSC)Chr 5: 139.85 – 140.04 MbChr 18: 36.02 – 36.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ErbB family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcripts encoding distinct isoforms have been described.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000158458 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000060275 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: NRG2 neuregulin 2".
  6. Chang H, Riese DJ, Gilbert W, Stern DF, McMahan UJ (May 1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509–12. doi:10.1038/387509a0. PMID 9168114. S2CID 4359654.
  7. Carraway KL, Weber JL, Unger MJ, Ledesma J, Yu N, Gassmann M, Lai C (May 1997). "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases". Nature. 387 (6632): 512–6. doi:10.1038/387512a0. PMID 9168115. S2CID 4310136.

Further reading


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