Flumetasone
Flumetasone, also known as flumethasone,[1] is a corticosteroid for topical use.
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| Other names | Flumethasone (USAN) |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| Routes of administration | Topical |
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| Pharmacokinetic data | |
| Metabolism | Hepatic, CYP3A4-mediated |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.016.701  |
| Chemical and physical data | |
| Formula | C22H28F2O5 |
| Molar mass | 410.458 g·mol−1 |
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It was patented in 1951 and approved for medical use in 1964.[2]
Chemistry
Flumethasone is 420 times as potent as cortisone in an animal model for anti-inflammatory activity.
Names
Trade names include Locacorten, Locorten, and Orsalin. It is available in combination with clioquinol, under the trade name Locacorten-Vioform (in some countries Locorten-Vioform), for the treatment of otitis externa and otomycosis. It is usually formulated as the pivalic acid ester prodrug called flumetasone pivalate.
References
- Morton IK, Hall JM (1999). Concise Dictionary of Pharmacological Agents Properties and Synonyms. Dordrecht: Springer Netherlands. p. 122. ISBN 9789401144391.
- Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 484. ISBN 9783527607495.
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