List of therapeutic monoclonal antibodies
This is a list of therapeutic, diagnostic and preventive monoclonal antibodies, antibodies that are clones of a single parent cell. When used as drugs, the International Nonproprietary Names (INNs) end in -mab. The remaining syllables of the INNs, as well as the column Source, are explained in Nomenclature of monoclonal antibodies.
Types of monoclonal antibodies with other structures than naturally occurring antibodies.
The abbreviations in the column Type are as follows:
- mab: whole monoclonal antibody
- Fab: fragment, antigen-binding (one arm)
- F(ab')2: fragment, antigen-binding, including hinge region (both arms)
- Fab': fragment, antigen-binding, including hinge region (one arm)
- Variable fragments:
- scFv: single-chain variable fragment
- di-scFv: dimeric single-chain variable fragment
- sdAb: single-domain antibody
- BsMAb: bispecific monoclonal antibodies:
- 3funct: trifunctional antibody
- BiTE: bi-specific T-cell engager
This list of over 500 monoclonal antibodies includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage. See the list of FDA-approved therapeutic monoclonal antibodies in the monoclonal antibody therapy page.
| Name | Trade name | Type | Source | Target | Approved | Use |
|---|---|---|---|---|---|---|
| 3F8 | mab | mouse | GD2 ganglioside | neuroblastoma | ||
| 8H9[1] | mab | mouse | B7-H3 | neuroblastoma, sarcoma, metastatic brain cancers | ||
| Abagovomab[2] | mab | mouse | CA-125 (imitation) | ovarian cancer | ||
| Abciximab[3] | ReoPro | Fab | chimeric | CD41 (integrin alpha-IIb) | Y | platelet aggregation inhibitor |
| Abituzumab[4] | mab | humanized | CD51 | cancer | ||
| Abrezekimab[5] | Fab | humanized | interleukin 13 | ? | ||
| Abrilumab[6] | mab | human | integrin α4β7 | inflammatory bowel disease, ulcerative colitis, Crohn's disease | ||
| Actoxumab[6] | mab | human | Clostridium difficile | Clostridium difficile colitis | ||
| Adalimumab[7] | Humira | mab | human | TNF-α | Y | rheumatoid arthritis, Crohn's disease, plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, juvenile idiopathic arthritis, hemolytic disease of the newborn |
| Adecatumumab[8] | mab | human | EpCAM | prostate and breast cancer | ||
| Aducanumab[9] | mab | human | beta-amyloid | Alzheimer's disease | ||
| Afasevikumab[10] | mab | human | IL17A and IL17F | multiple sclerosis | ||
| Afelimomab[3] | F(ab')2 | mouse | TNF-α | sepsis | ||
| Alacizumab pegol[11] | F(ab')2 | humanized | VEGFR2 | cancer | ||
| Alemtuzumab[12] | Lemtrada, Campath | mab | humanized | CD52 | Y | multiple sclerosis |
| Alirocumab[13] | Praluent | mab | human | PCSK9 | Y | hypercholesterolemia |
| Altumomab pentetate | Hybri-ceaker | mab | mouse | Carcinoembryonic antigen (CEA) | colorectal cancer (diagnosis) | |
| Amatuximab[14] | mab | chimeric | mesothelin | cancer | ||
| Amivantamab | bsmab | human | Epidermal growth factor receptor (EGFR), cMet | Y | non-small cell lung cancer | |
| Anatumomab mafenatox[15] | Fab | mouse | Tumor-associated glycoprotein 72 (TAG-72) | non-small cell lung cancer | ||
| Andecaliximab[16] | mab | chimeric | gelatinase B | gastric cancer or gastroesophageal junction adenocarcinoma | ||
| Anetumab ravtansine[4] | mab | human | mesothelin (MSLN) | cancer | ||
| Anifrolumab[4] | mab | human | interferon α/β receptor | systemic lupus erythematosus | ||
| Ansuvimab | Ebanga | mab | human | Ebola virus glycoprotein | Y | treatment of Zaire ebolavirus (Ebola virus) |
| Anrukinzumab[11] (= IMA-638)[17] | mab | humanized | IL-13 | asthma | ||
| Apolizumab[18] | mab | humanized | HLA-DR ? | hematological cancers | ||
| Aprutumab ixadotin[19] | mab | human | FGFR2 | ? | ||
| Arcitumomab[20] | CEA-Scan | Fab' | mouse | Carcinoembryonic antigen (CEA) | gastrointestinal cancers (diagnosis) | |
| Ascrinvacumab[10] | mab | human | activin receptor-like kinase 1 | cancer | ||
| Aselizumab[21] | mab | humanized | L-selectin (CD62L) | severely injured patients | ||
| Atezolizumab[22] | Tecentriq | mab | humanized | PD-L1 | Y | cancer |
| Atidortoxumab[23] | mab | human | Staphylococcus aureus alpha toxin | ? | ||
| Atinumab[14] | mab | human | RTN4 | ? | ||
| Atoltivimab | mab | human | part of Atoltivimab/maftivimab/odesivimab for treatment of Zaire ebolavirus (Ebola virus) | |||
| Atoltivimab/maftivimab/odesivimab | Inmazeb | mab | human | Y | treatment of Zaire ebolavirus (Ebola virus) | |
| Atorolimumab[3] | mab | human | Rhesus factor | hemolytic disease of the newborn | ||
| Avelumab[10] | Bavencio | mab | human | PD-L1 | Y | cancer |
| Azintuxizumab vedotin[24] | mab | chimeric/humanized | CD319 | cancer | ||
| Bamlanivimab | mab | human | COVID-19 | |||
| Bapineuzumab[25] | mab | humanized | beta amyloid | Alzheimer's disease | ||
| Basiliximab[26] | Simulect | mab | chimeric | CD25 (α chain of IL-2 receptor) | Y | prevention of organ transplant rejections |
| Bavituximab[2] | mab | chimeric | phosphatidylserine | cancer, viral infections | ||
| BCD-100 | ? | human | PD-1 | melanoma | ||
| Bectumomab[26] | LymphoScan | Fab' | mouse | CD22 | non-Hodgkin's lymphoma (detection) | |
| Begelomab[6] | mab | mouse | DPP4 | ? | ||
| Belantamab mafodotin[5] | Blenrep | mab | humanized | B-cell maturation antigen (BCMA) | Y | relapsed or refractory multiple myeloma |
| Belimumab[27] | Benlysta | mab | human | B-cell activating factor (BAFF) | Y | systemic lupus erythematosus without renal or CNS involvement |
| Bemarituzumab[23] | mab | humanized | FGFR2 | gastric cancer or gastroesophageal junction adenocarcinoma | ||
| Benralizumab[28] | Fasenra | mab | humanized | CD125 | Y | asthma |
| Berlimatoxumab[23] | mab | human | Staphylococcus aureus bi-component leukocidin | ? | ||
| Bermekimab[26] | Xilonix | mab | human | IL1A | colorectal cancer | |
| Bersanlimab[5] | mab | human | ICAM-1 | ? | ||
| Bertilimumab[21] | mab | human | CCL11 (eotaxin-1) | severe allergic disorders | ||
| Besilesomab[29] | Scintimun | mab | mouse | Carcinoembryonic antigen (CEA)-related antigen | inflammatory lesions and metastases (detection) | |
| Bevacizumab[12] | Avastin | mab | humanized | VEGF-A | Y | metastatic cancer, retinopathy of prematurity |
| Bezlotoxumab[26] | Zinplava | mab | human | Clostridium difficile | Y | Clostridium difficile colitis |
| Biciromab[26] | FibriScint | Fab' | mouse | fibrin II, beta chain | thromboembolism (diagnosis) | |
| Bimagrumab[30] | mab | human | ACVR2B | myostatin inhibitor | ||
| Bimekizumab[9] | mab | humanized | IL 17A and IL 17F | ankylosing spondylitis, psoriasis | ||
| Birtamimab | mab | chimeric | serum amyloid A protein | amyloidosis | ||
| Bivatuzumab[26] | mab | humanized | CD44 v6 | squamous cell carcinoma | ||
| Bleselumab[10] | mab | human | CD40 | organ transplant rejection | ||
| Blinatumomab[26] | Blincyto | BiTE | mouse | CD19 | Y | pre-B Acute lymphoblastic leukemia (ALL) (CD19+) |
| Blontuvetmab[31] | Blontress | mab | veterinary | CD20 | ||
| Blosozumab[32] | mab | humanized | SOST | osteoporosis | ||
| Bococizumab[26] | mab | humanized | PCSK9 | dyslipidemia | ||
| Brazikumab[16] | mab | human | IL23 | Crohn's disease | ||
| Brentuximab vedotin[26] | Adcentris | mab | chimeric | CD30 (TNFRSF8) | Y | Hodgkin's lymphoma |
| Briakinumab[26] | mab | human | IL-12, IL-23 | psoriasis, rheumatoid arthritis, inflammatory bowel diseases, multiple sclerosis | ||
| Brodalumab[32] | Siliq | mab | human | IL-17 | Y | Plaque psoriasis |
| Brolucizumab[22] | Beovu | scFv | humanized | vascular endothelial growth factor A (VEGFA) | Y | wet age-related macular degeneration |
| Brontictuzumab[6] | mab | humanized | Notch 1 | cancer | ||
| Burosumab[16] | Crysvita | mab | human | FGF 23 | Y | X-linked hypophosphatemia |
| Cabiralizumab[31] | mab | humanized | CSF1R | metastatic pancreatic cancer | ||
| Camidanlumab tesirine[23] | mab | human | CD25 (α chain of IL-2 receptor) | B-cell Hodgkin's lymphoma, non-Hodgkin lymphoma, acute lymphoblastic leukemia, acute myeloid leukemia | ||
| Camrelizumab[19] | mab | humanized | PD-1 | hepatocellular carcinoma | ||
| Canakinumab[33] | Ilaris | mab | human | IL-1 | Y | cryopyrin-associated periodic syndrome |
| Cantuzumab mertansine[32] | mab | humanized | CanAg (a glycoform of MUC1) | colorectal cancer etc. | ||
| Cantuzumab ravtansine[32] | mab | humanized | CanAg (a glycoform of MUC1) | cancers | ||
| Caplacizumab[34] | Cablivi | sdAb | humanized | VWF | Y | thrombotic thrombocytopenic purpura, thrombosis |
| Casirivimab | mab | human | spike protein receptor binding domain (RBD) of SARS-CoV-2 | COVID-19 | ||
| Capromab[26] | Prostascint | mab | mouse | Glutamate carboxypeptidase II | Y | prostate cancer (detection) |
| Carlumab[14] | mab | human | MCP-1 | oncology/immune indications | ||
| Carotuximab[31] | mab | chimeric | endoglin | angiosarcoma | ||
| Catumaxomab[25] | Removab | 3funct | rat/mouse hybrid | EpCAM, CD3 | Y | ovarian cancer, malignant ascites, gastric cancer |
| cBR96-doxorubicin immunoconjugate | mab | humanized | Lewis-Y antigen | cancer | ||
| Cedelizumab[35] | mab | humanized | CD4 | prevention of organ transplant rejections, treatment of autoimmune diseases | ||
| Cemiplimab[26] | Libtayo | mab | human | PDCD1 | Y | cutaneous squamous cell carcinoma |
| Cergutuzumab amunaleukin[10] | mab | humanized | IL2 | cancer | ||
| Certolizumab pegol[33] | Cimzia | Fab' | humanized | TNF-α | Y | Crohn's disease, rheumatoid arthritis, axial spondyloarthritis, psoriasis arthritis |
| Cetrelimab[5] | mab | human | PD-1 | cancer | ||
| Cetuximab[26] | Erbitux | mab | chimeric | Epidermal growth factor receptor (EGFR) | Y | metastatic colorectal cancer and head and neck cancer |
| Cibisatamab[5] | mab | humanized | CEACAM5 | cancer | ||
| Cirmtuzumab[26] | ? | humanized | ROR1 | chronic lymphocytic leukemia | ||
| Citatuzumab bogatox[36] | Fab | humanized | EpCAM | ovarian cancer and other solid tumors | ||
| Cixutumumab[26] | mab | human | IGF-1 receptor (CD221) | solid tumors | ||
| Clazakizumab[37] | mab | humanized | Interleukin 6 (IL-6) | rheumatoid arthritis | ||
| Clenoliximab[26] | mab | chimeric | CD4 | rheumatoid arthritis | ||
| Clivatuzumab tetraxetan[26] | hPAM4-Cide | mab | humanized | MUC1 | pancreatic cancer | |
| Codrituzumab[4] | mab | humanized | glypican 3 | cancer | ||
| Cofetuzumab pelidotin[23] | mab | humanized | PTK7 | cancer | ||
| Coltuximab ravtansine[4] | mab | chimeric | CD19 | cancer | ||
| Conatumumab[36] | mab | human | TRAIL-R2 | cancer | ||
| Concizumab[30] | mab | humanized | tissue factor pathway inhibitor (TFPI) | bleeding | ||
| Cosfroviximab[24] | ZMapp | mab | chimeric | ebolavirus glycoprotein | Ebola virus | |
| Crenezumab[26] | mab | humanized | 1-40-β-amyloid | Alzheimer's disease | ||
| Crizanlizumab[19] | Adakveo | mab | humanized | selectin P | Y | sickle-cell disease |
| Crotedumab[31] | mab | human | glucagon receptor (GCGR) | diabetes | ||
| CR6261 | mab | human | Influenza A hemagglutinin | infectious disease/influenza A | ||
| Cusatuzumab[5] | mab | humanized | CD70 | cancer | ||
| Dacetuzumab[11] | mab | humanized | CD40 | hematologic cancers | ||
| Daclizumab[38] | Zenapax | mab | humanized | CD25 (α chain of IL-2 receptor) | Y | prevention of organ transplant rejections, multiple sclerosis |
| Dalotuzumab | mab | humanized | IGF-1 receptor (CD221) | cancer etc. | ||
| Dapirolizumab pegol[9] | mab | humanized | CD154 (CD40L) | ? | ||
| Daratumumab[39] | Darzalex | mab | human | CD38 | Y | multiple myeloma |
| Dectrekumab[22] | mab | human | IL-13 | ? | ||
| Demcizumab | mab | humanized | DLL4 | cancer | ||
| Denintuzumab mafodotin[6] | mab | humanized | CD19 | cancer | ||
| Denosumab[40] | Prolia | mab | human | RANKL | Y | osteoporosis, bone metastases etc. |
| Depatuxizumab mafodotin[19] | mab | chimeric/humanized | EGFR | glioblastoma | ||
| Derlotuximab biotin | mab | chimeric | histone complex | recurrent glioblastoma multiforme | ||
| Detumomab | mab | mouse | B-lymphoma cell | lymphoma | ||
| Dezamizumab[19] | mab | humanized | serum amyloid P component | ? | ||
| Dinutuximab | Unituxin | mab | chimeric | GD2 ganglioside | Y | neuroblastoma |
| Dinutuximab beta | Qarziba | mab | chimeric | GD2 ganglioside | Y | neuroblastoma |
| Diridavumab | mab | human | hemagglutinin | influenza A | ||
| Domagrozumab[31] | mab | humanized | GDF-8 | Duchenne muscular dystrophy | ||
| Dorlimomab aritox[41] | F(ab')2 | mouse | ? | ? | ||
| Dostarlimab[42] | mab | humanized | PCDP1 | cancer | ||
| Drozitumab | mab | human | DR5 | cancer etc. | ||
| DS-8201 | ? | humanized | HER2 | gastric or gastroesophageal junction adenocarcinoma | ||
| Duligotuzumab[13] | mab | humanized | ERBB3 (HER3) | testicular cancer | ||
| Dupilumab[30] | Dupixent | mab | human | IL-4Rα | Y | atopic dermatitis, asthma, nasal polyps |
| Durvalumab[22] | Imfinzi | mab | human | PD-L1 | Y | cancer |
| Dusigitumab | mab | human | ILGF2 | B-cell malignancies | ||
| Duvortuxizumab[24] | scFv | chimeric/humanized | CD19, CD3E | cancer | ||
| Ecromeximab[18] | mab | chimeric | GD3 ganglioside | malignant melanoma | ||
| Eculizumab[18] | Soliris | mab | humanized | C5 | Y | paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome |
| Edobacomab | mab | mouse | endotoxin | sepsis caused by Gram-negative bacteria | ||
| Edrecolomab | Panorex | mab | mouse | EpCAM | colorectal carcinoma | |
| Efalizumab[7] | Raptiva | mab | humanized | LFA-1 (CD11a) | psoriasis (blocks T-cell migration) | |
| Efungumab[2] | Mycograb | scFv | human | Hsp90 | invasive Candida infection | |
| Eldelumab[4] | mab | human | interferon gamma-induced protein | Crohn's disease, ulcerative colitis | ||
| Elezanumab[19] | mab | human | repulsive guidance molecule A (RGMA) | spinal cord injury and multiple sclerosis | ||
| Elgemtumab[22] | mab | human | ERBB3 (HER3) | cancer | ||
| Elotuzumab | Empliciti | mab | humanized | SLAMF7 | Y | multiple myeloma |
| Elsilimomab | mab | mouse | IL-6 | ? | ||
| Emactuzumab[6] | mab | humanized | CSF1R | cancer | ||
| Emapalumab[19] | Gamifant | mab | human | interferon gamma | Y | hemophagocytic lymphohistiocytosis |
| Emibetuzumab | mab | humanized | hHGFR | cancer | ||
| Emicizumab[10] | Hemlibra | mab | humanized | activated F9, F10 | Y | haemophilia A |
| Enapotamab vedotin[5] | mab | human | AXL | cancer | ||
| Enavatuzumab | mab | humanized | TWEAK receptor | cancer etc. | ||
| Enfortumab vedotin | Padcev | mab | human | nectin-4 | Y | urothelial cancer |
| Enlimomab pegol[43] | mab | mouse | ICAM-1 (CD54) | ? | ||
| Enoblituzumab[19] | mab | humanized | CD276 | cancer | ||
| Enokizumab | mab | humanized | IL9 | asthma | ||
| Enoticumab[13] | mab | human | DLL4 | ? | ||
| Ensituximab | mab | chimeric | MUC5AC | cancer | ||
| Epcoritamab | bsmab | human | CD3, CD20 | B-cell lymphoma | ||
| Epitumomab cituxetan[44] | mab | mouse | episialin | ? | ||
| Epratuzumab | mab | humanized | CD22 | cancer, systemic lupus erythematosus (SLE) | ||
| Eptinezumab[19] | Vyepti | mab | humanized | calcitonin gene-related peptide | Y | migraine |
| Erenumab[19] | Aimovig | mab | human | calcitonin gene-related peptide receptor (CGRP) | Y | migraine |
| Erlizumab[45] | F(ab')2 | humanized | ITGB2 (CD18) | heart attack, stroke, traumatic shock | ||
| Ertumaxomab[25] | Rexomun | 3funct | rat/mouse hybrid | HER2/neu, CD3 | Y | breast cancer etc. |
| Etaracizumab | Abegrin | mab | humanized | integrin αvβ3 | Y | melanoma, prostate cancer, ovarian cancer etc. |
| Etigilimab[5] | mab | humanized | TIGIT | ? | ||
| Etrolizumab[14] | mab | humanized | integrin β7 | inflammatory bowel disease | ||
| Evinacumab | mab | human | angiopoietin 3 | dyslipidemia | ||
| Evolocumab[30] | Repatha | mab | human | PCSK9 | Y | hypercholesterolemia |
| Exbivirumab[46] | mab | human | hepatitis B surface antigen | hepatitis B | ||
| Fanolesomab[15] | NeutroSpec | mab | mouse | CD15 | appendicitis (diagnosis) | |
| Faralimomab | mab | mouse | interferon receptor | ? | ||
| Faricimab[5] | mab | humanized | VEGF-A and Ang-2 | angiogenesis, ocular vascular diseases | ||
| Farletuzumab | mab | humanized | folate receptor 1 | ovarian cancer | ||
| Fasinumab | mab | human | Nerve growth factor (HNGF) | acute sciatic pain | ||
| FBTA05[47][48] | Lymphomun | 3funct | rat/mouse hybrid | CD20 | chronic lymphocytic leukaemia | |
| Felvizumab | mab | humanized | respiratory syncytial virus | respiratory syncytial virus infection | ||
| Fezakinumab[49][50] | mab | human | IL-22 | rheumatoid arthritis, psoriasis | ||
| Fibatuzumab[10] | mab | humanized | ephrin receptor A3 | ? | ||
| Ficlatuzumab | mab | humanized | Hepatocyte growth factor (HGF) | cancer etc. | ||
| Figitumumab | mab | human | IGF-1 receptor (CD221) | adrenocortical carcinoma, non-small cell lung carcinoma etc. | ||
| Firivumab[6] | mab | human | influenza A virus hemagglutinin | ? | ||
| Flanvotumab | mab | human | TYRP1 (glycoprotein 75) | melanoma | ||
| Fletikumab | mab | human | IL 20 | rheumatoid arthritis | ||
| Flotetuzumab[5] | di-scFv | humanized | IL 3 receptor | hematological malignancies | ||
| Fontolizumab[18] | HuZAF | mab | humanized | IFN-γ | Crohn's disease etc. | |
| Foralumab[51] | mab | human | CD3 epsilon | ? | ||
| Foravirumab[36] | mab | human | rabies virus glycoprotein | rabies (prophylaxis) | ||
| Fremanezumab[19] | Ajovy | mab | humanized | calcitonin gene-related peptide alpha | Y | migraine and cluster headache |
| Fresolimumab[39] | mab | human | TGF-β | idiopathic pulmonary fibrosis, focal segmental glomerulosclerosis, cancer | ||
| Frovocimab[42] | mab | humanized | PCSK9 | hypercholesterolemia | ||
| Frunevetmab[24] | mab | veterinary | nerve growth factor (NGF) | ? | ||
| Fulranumab | mab | human | Nerve growth factor (NGF) | pain | ||
| Futuximab[13] | mab | chimeric | Epidermal growth factor receptor (EGFR) | cancer | ||
| Galcanezumab[31] | Emgality | mab | humanized | calcitonin | Y | migraine |
| Galiximab | mab | chimeric | CD80 | B-cell lymphoma | ||
| Gancotamab | scFv | human | HER2/neu | cancer | ||
| Ganitumab | mab | human | IGF-1 receptor (CD221) | cancer | ||
| Gantenerumab[33] | mab | human | beta amyloid | Alzheimer's disease | ||
| Gatipotuzumab[24] | mab | humanized | MUC1 | cancer | ||
| Gavilimomab[45] | mab | mouse | CD147 (basigin) | graft versus host disease | ||
| Gedivumab[24] | mab | human | hemagglutinin HA | ? | ||
| Gemtuzumab ozogamicin[19] | Mylotarg | mab | humanized | CD33 | Y | acute myelogenous leukemia |
| Gevokizumab | mab | humanized | IL-1β | diabetes etc. | ||
| Gilvetmab[24] | mab | veterinary | PCDC1 | ? | ||
| Gimsilumab[23] | mab | human | CSF2 | rheumatoid arthritis | ||
| Girentuximab[39] | Rencarex | mab | chimeric | carbonic anhydrase 9 (CA-IX) | clear cell renal cell carcinoma[52] | |
| Glembatumumab vedotin[28][53] | mab | human | GPNMB | melanoma, breast cancer | ||
| Golimumab[46] | Simponi | mab | human | TNF-α | Y | rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis |
| Gomiliximab | mab | chimeric | CD23 (IgE receptor) | allergic asthma | ||
| Gosuranemab | mab | humanized | tau protein | progressive supranuclear palsy | ||
| Guselkumab | Tremfya | mab | human | IL23 | Y | psoriasis |
| Ianalumab[23] | mab | human | BAFF-R | autoimmune hepatitis | ||
| Ibalizumab[33] | Trogarzo | mab | humanized | CD4 | Y | HIV infection |
| IBI308 | ? | human | PD-1 | squamous cell non-small cell lung cancer | ||
| Ibritumomab tiuxetan | Zevalin | mab | mouse | CD20 | Y | non-Hodgkin's lymphoma |
| Icrucumab | mab | human | VEGFR-1 | cancer etc. | ||
| Idarucizumab[4] | Praxbind | mab | humanized | dabigatran | Y | reversal of anticoagulant effects of dabigatran |
| Ifabotuzumab[19] | mab | humanized | EPHA3 | glioblastoma multiforme[54] | ||
| Igovomab | Indimacis-125 | F(ab')2 | mouse | CA-125 | ovarian cancer (diagnosis) | |
| Iladatuzumab vedotin[23] | mab | humanized | CD79B | cancer | ||
| IMAB362 | mab | human | CLDN18.2 | gastrointestinal adenocarcinomas and pancreatic tumor | ||
| Imalumab[6] | mab | human | macrophage migration inhibitory factor (MIF) | cancer | ||
| Imaprelimab[5] | mab | humanized | melanoma cell adhesion molecule (MCAM) | ? | ||
| Imciromab | Myoscint | mab | mouse | cardiac myosin | Y | cardiac imaging |
| Imdevimab | mab | human | spike protein receptor binding domain (RBD) of SARS-CoV-2 | COVID-19 | ||
| Imgatuzumab[13] | mab | humanized | Epidermal growth factor receptor (EGFR) | cancer | ||
| Inclacumab[34] | mab | human | selectin P | cardiovascular disease | ||
| Indatuximab ravtansine[32] | mab | chimeric | SDC1 | cancer | ||
| Indusatumab vedotin[22] | mab | human | GUCY2C | cancer | ||
| Inebilizumab[10] | Uplizna | mab | humanized | CD19 | Y | cancer, systemic sclerosis, multiple sclerosis |
| Infliximab | Remicade | mab | chimeric | TNF-α | Y | rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis, Crohn's disease, ulcerative colitis |
| Intetumumab[55][56] | mab | human | CD51 | solid tumors (prostate cancer, melanoma) | ||
| Inolimomab | mab | mouse | CD25 (α chain of IL-2 receptor) | graft versus host disease | ||
| Inotuzumab ozogamicin[29] | Besponsa | mab | humanized | CD22 | Y | Acute lymphoblastic leukemia (ALL) |
| Ipilimumab[40] | Yervoy | mab | human | CD152 | Y | melanoma |
| Iomab-B | ? | mouse | CD45 | ablation of bone marrow | ||
| Iratumumab[40] | mab | human | CD30 (TNFRSF8) | Hodgkin's lymphoma | ||
| Isatuximab | Sarclisa | mab | chimeric | CD38 | Y | multiple myeloma |
| Iscalimab[5] | mab | human | CD40 | ? | ||
| Istiratumab[23] | mab | human | IGF1R, CD221 | advanced solid tumors | ||
| Itolizumab[51] | Alzumab | mab | humanized | CD6 | Y | psoriasis |
| Ixekizumab | Taltz | mab | humanized | IL 17A | Y | autoimmune diseases |
| Keliximab | mab | chimeric | CD4 | chronic asthma | ||
| Labetuzumab[7] | CEA-Cide | mab | humanized | Carcinoembryonic antigen (CEA) | colorectal cancer | |
| Lacnotuzumab[24] | mab | humanized | CSF1, macrophage colony stimulating factor (MCSF) | cancer | ||
| Ladiratuzumab vedotin[23] | mab | humanized | LIV-1 | cancer | ||
| Lampalizumab[13] | Fab | humanized | Complement factor D (CFD) | geographic atrophy secondary to age-related macular degeneration | ||
| Lanadelumab[31] | Takhzyro | mab | human | kallikrein | Y | angioedema |
| Landogrozumab[10] | mab | humanized | GDF-8 | muscle wasting disorders | ||
| Laprituximab emtansine[31] | mab | chimeric | epidermal growth factor receptor (EGFR) | ? | ||
| Larcaviximab[24] | mab | chimeric | ebolavirus glycoprotein | Ebola virus | ||
| Lebrikizumab | mab | humanized | IL-13 | asthma | ||
| Lemalesomab[45] | mab | mouse | NCA-90 (granulocyte antigen) | diagnostic agent | ||
| Lendalizumab[31] | mab | humanized | C5 | ? | ||
| Lenvervimab[5] | mab | humanized | hepatitis B surfage antigen | hepatitis B | ||
| Lenzilumab[6] | mab | human | CSF2 | chronic myelomonocytic leukemia and juvenile myelomonocytic leukemia | ||
| Lerdelimumab[15] | mab | human | TGF beta 2 | reduction of scarring after glaucoma surgery | ||
| Leronlimab[5] | mab | humanized | CCR5 | breast cancer, HIV | ||
| Lesofavumab[24] | mab | human | hemagglutinin HA | ? | ||
| Letolizumab[24] | scFv | humanized | tumor necrosis factor related activation protein (TRAP) | inflammatory diseases | ||
| Lexatumumab[2] | mab | human | TRAIL-R2 | cancer | ||
| Libivirumab[46] | mab | human | hepatitis B surface antigen | hepatitis B | ||
| Lifastuzumab vedotin | mab | humanized | phosphate-sodium co-transporter | cancer | ||
| Ligelizumab[13] | mab | humanized | IGHE | severe asthma and chronic spontaneous urticaria | ||
| Loncastuximab tesirine[23] | mab | chimeric | CD19 | cancer | ||
| Losatuxizumab vedotin[24] | mab | chimeric/humanized | epidermal growth receptor factor (EGRF), ERBB1 HER1 | cancer | ||
| Lilotomab satetraxetan[22] | mab | mouse | CD37 | cancer | ||
| Lintuzumab | mab | humanized | CD33 | cancer | ||
| Lirilumab[13] | mab | human | KIR2D | solid and hematological cancers | ||
| Lodelcizumab[30] | mab | humanized | PCSK9 | hypercholesterolemia | ||
| Lokivetmab[22] | Cytopoint[57] | mab | veterinary | Canis lupus familiaris IL31 | Y | clinical signs of atopic dermatitis in dogs[57] |
| Lorvotuzumab mertansine | mab | humanized | CD56 | cancer | ||
| Lucatumumab[11] | mab | human | CD40 | multiple myeloma, non-Hodgkin's lymphoma, Hodgkin's lymphoma | ||
| Lulizumab pegol[6] | mab | humanized | CD28 | autoimmune diseases | ||
| Lumiliximab[8] | mab | chimeric | CD23 (IgE receptor) | chronic lymphocytic leukemia | ||
| Lumretuzumab[6] | mab | humanized | ERBB3 (HER3) | cancer | ||
| Lupartumab[19] | mab | human | ? | |||
| Lupartumab amadotin[19] | mab | human | LYPD3 | ? | ||
| Lutikizumab[19] | mab | humanized | interleukin 1 alpha | ? | ||
| Maftivimab | mab | human | part of Atoltivimab/maftivimab/odesivimab for treatment of Zaire ebolavirus (Ebola virus) | |||
| Mapatumumab[25] | mab | human | TRAIL-R1 | cancer | ||
| Margetuximab | Margenza[58] | mab | humanized | HER2 | Y | breast cancer |
| Marstacimab | mab | human | tissue factor pathway inhibitor (TFPI) | bleeding with hemophilia | ||
| Maslimomab | ? | mouse | T-cell receptor | |||
| Mavrilimumab[28] | mab | human | GMCSF receptor α-chain | rheumatoid arthritis | ||
| Matuzumab[21] | mab | humanized | Epidermal growth factor receptor (EGFR) | colorectal, lung and stomach cancer | ||
| Mepolizumab[35] | Bosatria | mab | humanized | IL-5 | Y | asthma and white blood cell diseases |
| Metelimumab[21] | mab | human | TGF beta 1 | systemic scleroderma | ||
| Milatuzumab[11] | mab | humanized | CD74 | multiple myeloma and other hematological malignancies | ||
| Minretumomab | mab | mouse | TAG-72 | tumor detection (and therapy?) | ||
| Mirikizumab[23] | mab | humanized | IL23A | psoriasis | ||
| Mirvetuximab soravtansine | mab | chimeric | folate receptor alpha | ovarian cancer | ||
| Mitumomab | mab | mouse | GD3 ganglioside | small cell lung carcinoma | ||
| Modotuximab | mab | chimeric | EGFR extracellular domain III | cancer | ||
| Mogamulizumab[14] | Poteligeo | mab | humanized | CCR4 | Y | adult T-cell leukemia/lymphoma |
| Monalizumab[10] | mab | humanized | NKG2A | rheumatoid arthritis, gynecologic malignancies, and other cancers | ||
| Morolimumab[59] | mab | human | Rhesus factor | |||
| Mosunetuzumab[23] | mab | humanized | CD3E, MS4A1, CD20 | cancer | ||
| Motavizumab[2] | Numax | mab | humanized | respiratory syncytial virus | respiratory syncytial virus (prevention) | |
| Moxetumomab pasudotox | Lumoxiti | mab | mouse | CD22 | Y | hairy cell leukemia |
| Muromonab-CD3 | Orthoclone OKT3 | mab | mouse | CD3 | prevention of organ transplant rejections | |
| Nacolomab tafenatox | Fab | mouse | C242 antigen | colorectal cancer | ||
| Namilumab[14] | mab | human | CSF2 | |||
| Naptumomab estafenatox[60] | Fab | mouse | 5T4 | non-small cell lung carcinoma, renal cell carcinoma | ||
| Naratuximab emtansine[31] | mab | chimeric | CD37 | |||
| Narnatumab | mab | human | MST1R (aka RON) | cancer | ||
| Natalizumab[59] | Tysabri | mab | humanized | integrin α4 | Y | multiple sclerosis, Crohn's disease |
| Navicixizumab[31] | mab | chimeric/humanized | DLL4 and VEGFA | cancer | ||
| Navivumab[10] | mab | human | influenza A virus hemagglutinin HA | |||
| Naxitamab | Danyelza | ? | humanized | c-Met | Y | high-risk neuroblastoma and refractory osteomedullary disease |
| Nebacumab | mab | human | endotoxin | sepsis | ||
| Necitumumab[61] | Portrazza | mab | human | Epidermal growth factor receptor (EGFR) | Y | non-small cell lung carcinoma |
| Nemolizumab[22] | mab | humanized | IL31RA | eczema[62] | ||
| NEOD001 | ? | humanized | amyloid | primary systemic amyloidosis | ||
| Nerelimomab | mab | mouse | TNF-α | ? | ||
| Nesvacumab | mab | human | angiopoietin 2 | cancer | ||
| Netakimab[5] | Efleira | mab | chimeric | interleukin 17A | plaque psoriasis | |
| Nimotuzumab[40][63] | BioMab-EGFR, Theracim, Theraloc | mab | humanized | epidermal growth factor receptor (EGFR) | Y | squamous cell carcinoma, head and neck cancer, nasopharyngeal cancer, glioma |
| Nirsevimab | mab | human | RSV fusion glycoprotein | respiratory syncytial virus | ||
| Nivolumab[6] | Opdivo | mab | human | PD-1 | Y | cancer |
| Nofetumomab merpentan | Verluma | Fab | mouse | ? | cancer (diagnosis) | |
| Obiltoxaximab | Anthim | mab | chimeric | Bacillus anthracis anthrax | Y | Bacillus anthracis spores |
| Obinutuzumab | Gazyva | mab | humanized | CD20 | Y | chronic lymphatic leukemia |
| Ocaratuzumab | mab | humanized | CD20 | cancer | ||
| Ocrelizumab[2] | Ocrevus | mab | humanized | CD20 | Y | multiple sclerosis |
| Odesivimab | mab | human | part of Atoltivimab/maftivimab/odesivimab for treatment of Zaire ebolavirus (Ebola virus) | |||
| Odulimomab | mab | mouse | LFA-1 (CD11a) | prevention of organ transplant rejections, immunological diseases | ||
| Ofatumumab[25] | Arzerra, Kesimpta[64] | mab | human | CD20 | Y | chronic lymphocytic leukemia |
| Olaratumab | Lartruvo | mab | human | PDGF-R α | Y | cancer |
| Oleclumab[24] | mab | human | 5'-nucleotidase | pancreatic and colorectal cancer | ||
| Olendalizumab[24] | mab | humanized | complement C5a | systemic lupus erythematosus, lupus nephritis, acute graft-versus-hose disease | ||
| Olokizumab[51] | mab | humanized | IL6 | rheumatoid arthritis | ||
| Omalizumab[45] | Xolair | mab | humanized | IgE Fc region | Y | allergic asthma |
| Omburtamab[42] | mab | mouse | CD276 | cancer | ||
| OMS721 | ? | human | MASP-2 | atypical hemolytic uremic syndrome | ||
| Onartuzumab | Fab | humanized | human scatter factor receptor kinase | cancer | ||
| Ontuxizumab | mab | chimeric/humanized | TEM1 | cancer | ||
| Onvatilimab[5] | mab | human | VISTA (protein) (VSIR) | ? | ||
| Opicinumab | mab | human | LINGO-1 | multiple sclerosis | ||
| Oportuzumab monatox[61] | Vicinium | scFv | humanized | EpCAM | bladder cancer | |
| Oregovomab[15] | OvaRex | mab | mouse | CA-125 | ovarian cancer | |
| Orticumab[13] | mab | human | oxLDL | |||
| Otelixizumab[11] | mab | chimeric/humanized | CD3 | diabetes mellitus type 1 | ||
| Otilimab | mab | human | GMCSF | osteoarthritis, rheumatoid arthritis | ||
| Otlertuzumab | mab | humanized | CD37 | cancer | ||
| Oxelumab[32] | mab | human | OX-40 | asthma | ||
| Ozanezumab | mab | humanized | NOGO-A | ALS and multiple sclerosis | ||
| Ozoralizumab[32] | mab | humanized | TNF-α | inflammation | ||
| Pagibaximab[25] | mab | chimeric | lipoteichoic acid | sepsis (Staphylococcus) | ||
| Palivizumab | Synagis, Abbosynagis | mab | humanized | F protein of respiratory syncytial virus | Y | respiratory syncytial virus (prevention) |
| Pamrevlumab[10] | mab | human | connective tissue growth factor (CTGF) | idiopathic pulmonary fibrosis (IPF), pancreatic cancer | ||
| Panitumumab[46] | Vectibix | mab | human | epidermal growth factor receptor (EGFR) | Y | colorectal cancer |
| Pankomab | mab | humanized | tumor specific glycosylation of MUC1 | ovarian cancer | ||
| Panobacumab[61] | mab | human | Pseudomonas aeruginosa | Pseudomonas aeruginosa infection | ||
| Parsatuzumab[13] | mab | humanized | EGFL7 | cancer | ||
| Pascolizumab[18] | mab | humanized | IL-4 | asthma | ||
| Pasotuxizumab[6] | mab | chimeric/humanized | folate hydrolase | cancer | ||
| Pateclizumab[32] | mab | humanized | lymphotoxin alpha (LTA) | TNF | ||
| Patritumab[34] | mab | human | ERBB3 (HER3) | cancer | ||
| PDR001 | ? | humanized | PD-1 | melanoma | ||
| Pembrolizumab[9] | Keytruda | mab | humanized | PD-1 | Y | melanoma and other cancers |
| Pemtumomab | Theragyn | ? | mouse | MUC1 | cancer | |
| Perakizumab[13] | mab | humanized | IL 17A | arthritis | ||
| Pertuzumab | Perjeta | mab | humanized | HER2/neu | Y | cancer |
| Pexelizumab[15] | scFv | humanized | C5 | reduction of side effects of cardiac surgery | ||
| Pidilizumab[30] | mab | humanized | PD-1 | cancer and infectious diseases | ||
| Pinatuzumab vedotin[30] | mab | humanized | CD22 | cancer | ||
| Pintumomab | mab | mouse | adenocarcinoma antigen | adenocarcinoma (imaging) | ||
| Placulumab[13] | mab | human | human TNF | pain and inflammatory diseases | ||
| Prezalumab[31] | mab | human | human TNF | |||
| Plozalizumab[10] | mab | humanized | CCR2 | diabetic nephropathy and arteriovenous graft patency | ||
| Pogalizumab[31] | mab | humanized | tumor necrosis factor receptor (TNFR) superfamily member 4 | ? | ||
| Polatuzumab vedotin[30] | Polivy | mab | humanized | CD79B | Y | diffuse large B-cell lymphoma |
| Ponezumab | mab | humanized | human beta-amyloid | Alzheimer's disease | ||
| Porgaviximab[24] | mab | chimeric | Zaire ebolavirus glycoprotein | Ebola virus disease | ||
| Prasinezumab[23] | mab | humanized | sodium cyclopentadienide (NACP) | Parkinson's disease | ||
| Prezalizumab[31] | mab | humanized | inducible T-cell co-stimulatory ligand (ICOSL) | ? | ||
| Priliximab | mab | chimeric | CD4 | Crohn's disease, multiple sclerosis | ||
| Pritoxaximab[30] | mab | chimeric | E. coli shiga toxin type-1 | ? | ||
| Pritumumab | mab | human | vimentin | brain cancer | ||
| PRO 140 | ? | humanized | CCR5 | HIV infection | ||
| Quilizumab[34] | mab | humanized | IGHE | asthma | ||
| Racotumomab[61] | Vaxira | mab | mouse | NGNA ganglioside | Y | non-small cell lung cancer |
| Radretumab[14] | mab | human | fibronectin extra domain-B | cancer | ||
| Rafivirumab[36] | mab | human | rabies virus glycoprotein | rabies (prophylaxis) | ||
| Ralpancizumab | mab | humanized | PCSK9 | dyslipidemia | ||
| Ramucirumab | Cyramza | mab | human | VEGFR2 | Y | solid tumors |
| Ranevetmab | mab | veterinary | NGF | osteoarthritis in dogs | ||
| Ranibizumab[8] | Lucentis | Fab | humanized | VEGF-A | Y | macular degeneration (wet form) |
| Raxibacumab[29] | mab | human | anthrax toxin, protective antigen | Y | anthrax (prophylaxis and treatment) | |
| Ravagalimab[5] | mab | humanized | CD40 | Crohn's disease | ||
| Ravulizumab[23] | Ultomiris | mab | humanized | C5 | Y | paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome |
| Refanezumab | mab | humanized | myelin-associated glycoprotein | recovery of motor function after stroke | ||
| Regavirumab | mab | human | cytomegalovirus glycoprotein B | cytomegalovirus infection | ||
| REGN-EB3 | mab | human | 3 mabs for ebola infection with FDA orphan drug status | |||
| Relatlimab | mab | human | LAG3 | melanoma | ||
| Remtolumab[19] | mab | human | interleukin 17 alpha, TNF | ? | ||
| Reslizumab[7] | Cinqair | mab | humanized | IL-5 | Y | inflammations of the airways, skin and gastrointestinal tract |
| Rilotumumab | mab | human | hepatocyte growth factor (HGF) | solid tumors | ||
| Rinucumab | mab | human | platelet-derived growth factor receptor beta | neovascular age-related macular degeneration | ||
| Risankizumab[10] | Skyrizi | mab | humanized | IL23A | Y | Crohn's disease, psoriasis, psoriatic arthritis, and asthma |
| Rituximab | MabThera, Rituxan | mab | chimeric | CD20 | Y | lymphomas, leukemias, some autoimmune disorders |
| Rivabazumab pegol[10] | mab | humanized | Pseudomonas aeruginosa type III secretion system | ? | ||
| Robatumumab | mab | human | IGF-1 receptor (CD221) | cancer | ||
| Rmab | RabiShield | ? | human | rabies virus G glycoprotein | Y | post-exposure prophylaxis of rabies |
| Roledumab[51] | mab | human | RHD (gene) (RHD) | Rh disease | ||
| Romilkimab[5] | mab | chimeric/humanized | interleukin 13 | ? | ||
| Romosozumab | Evenity | mab | humanized | sclerostin | Y | osteoporosis |
| Rontalizumab[39] | mab | humanized | IFN-α | systemic lupus erythematosus | ||
| Rosmantuzumab[19] | mab | humanized | root plate-specific spondin 3 | cancer | ||
| Rovalpituzumab tesirine[10] | mab | humanized | DLL3 | small cell lung cancer | ||
| Rovelizumab[35] | LeukArrest | mab | humanized | CD11, CD18 | Y | haemorrhagic shock etc. |
| Rozanolixizumab[19] | mab | chimeric/humanized | FCGRT | Immune thrombocytopenic purpura (ITP), myasthenia gravis | ||
| Ruplizumab[12] | Antova | mab | humanized | CD154 (CD40L) | Y | rheumatic diseases |
| SA237 | ? | humanized | IL-6R | neuromyelitis optica and neuromyelitis optica spectrum disorders | ||
| Sacituzumab govitecan[19] | Trodelvy | mab | humanized | TROP-2 | Y | triple-negative breast cancer |
| Samalizumab[32] | mab | humanized | CD200 | cancer | ||
| Samrotamab vedotin[5] | mab | chimeric/humanized | LRRC15 | cancer | ||
| Sarilumab[34] | Kevzara | mab | human | IL6 | Y | rheumatoid arthritis, ankylosing spondylitis |
| Satralizumab[65] | Enspryng | mab | humanized | IL6 receptor | Y | neuromyelitis optica |
| Satumomab pendetide | mab | mouse | TAG-72 | cancer (diagnosis) | ||
| Secukinumab | Cosentyx | mab | human | IL 17A | Y | uveitis, rheumatoid arthritis psoriasis |
| Selicrelumab[24] | mab | human | CD40 | ? | ||
| Seribantumab[30] | mab | human | ERBB3 (HER3) | cancer | ||
| Setoxaximab[30] | mab | chimeric | E. coli shiga toxin type-2 | ? | ||
| Setrusumab[23] | mab | human | sclerostin (SOST) | ? | ||
| Sevirumab | ? | human | cytomegalovirus | cytomegalovirus infection | ||
| Sibrotuzumab | mab | humanized | FAP (gene) (FAP) | cancer | ||
| SGN-CD19A | mab | humanized | CD19 | acute lymphoblastic leukemia and B-cell non-Hodgkin lymphoma | ||
| SHP647 | ? | human | mucosal addressin cell adhesion molecule | Crohn's disease | ||
| Sifalimumab[14] | mab | human | IFN-α | systemic lupus erythematosus (SLE), dermatomyositis, polymyositis | ||
| Siltuximab | Sylvant | mab | chimeric | IL-6 | Y | cancer |
| Simtuzumab[13] | mab | humanized | LOXL2 | fibrosis | ||
| Siplizumab[18] | mab | humanized | CD2 | psoriasis, graft-versus-host disease (prevention) | ||
| Sirtratumab vedotin[23] | mab | human | SLITRK6 | cancer | ||
| Sirukumab | mab | human | IL-6 | rheumatoid arthritis | ||
| Sofituzumab vedotin | mab | humanized | CA-125 | ovarian cancer | ||
| Solanezumab[61] | mab | humanized | beta amyloid | Alzheimer's disease | ||
| Solitomab[34] | BiTE | mouse | EpCAM | gastrointestinal, lung, and other cancers | ||
| Sonepcizumab[66] | ? | humanized | sphingosine-1-phosphate | choroidal and retinal neovascularization | ||
| Sontuzumab[63] | mab | humanized | episialin | |||
| Spartalizumab[23] | mab | humanized | PDCD1, CD279 | melanoma | ||
| Stamulumab[2] | mab | human | myostatin | muscular dystrophy | ||
| Sulesomab | LeukoScan | Fab' | mouse | NCA-90 (granulocyte antigen) | osteomyelitis (imaging) | |
| Suptavumab[19] | mab | human | RSVFR | medically attended lower respiratory disease | ||
| Sutimlimab[5] | mab | chimeric/humanized | C1s | cold agglutinin disease | ||
| Suvizumab[28] | mab | humanized | HIV-1 | viral infections | ||
| Suvratoxumab[24] | mab | human | Staphylococcus aureus alpha toxin | nosocomial pneumonia | ||
| Tabalumab[32] | mab | human | B-cell activating factor (BAFF) | B-cell cancers | ||
| Tacatuzumab tetraxetan | AFP-Cide | mab | humanized | alpha-fetoprotein | cancer | |
| Tadocizumab[63] | Fab | humanized | integrin αIIbβ3 | percutaneous coronary intervention | ||
| Tafasitamab[35] | Monjuvi | mab | humanized (from mouse) | CD19 | Y | relapsed or refractory diffuse large B-cell lymphoma |
| Talacotuzumab[23] | mab | humanized | CD123 | leukemia etc. | ||
| Talizumab[27] | mab | humanized | IgE | allergic reaction | ||
| Talquetamab | bsmab | human | GPRC5D, CD3 | Y | relapsed or refractory multiple myeloma | |
| Tamtuvetmab[31] | Tactress | mab | veterinary | CD52 | ||
| Tanezumab[36] | mab | humanized | nerve growth factor (NGF) | pain | ||
| Taplitumomab paptox[45] | mab | mouse | CD19 | cancer | ||
| Tarextumab | mab | human | Notch receptor | cancer | ||
| Tavolimab | mab | chimeric/humanized | CD134 | cancer | ||
| Teclistamab | bsmab | human | B-cell maturation antigen (BCMA), CD3 | Y | relapsed or refractory multiple myeloma | |
| Tefibazumab[29] | Aurexis | mab | humanized | clumping factor A | Staphylococcus aureus infection | |
| Telimomab aritox | Fab | mouse | ? | |||
| Telisotuzumab[19] | mab | humanized | HGFR | cancer | ||
| Telisotuzumab vedotin[19] | mab | humanized | HGFR | cancer | ||
| Tenatumomab[11] | mab | mouse | tenascin C | cancer | ||
| Teneliximab[18] | mab | chimeric | CD40 | autoimmune diseases and prevention of organ transplant rejection | ||
| Teplizumab[33] | mab | humanized | CD3 | diabetes mellitus type 1 | ||
| Tepoditamab[5] | mab | human | dendritic cell-associated lectin 2 | cancer | ||
| Teprotumumab | Tepezza | mab | human | IGF-1 receptor (CD221) | Y | thyroid eye disease |
| Tesidolumab[22] | mab | human | C5 | |||
| Tetulomab | mab | humanized | CD37 | cancer[67] | ||
| Tezepelumab[10] | mab | human | thymic stromal lymphopoietin (TSLP) | asthma, atopic dermatitis | ||
| TGN1412 | ? | humanized | CD28 | chronic lymphocytic leukemia, rheumatoid arthritis | ||
| Tibulizumab[23] | mab | humanized | B-cell activating factor (BAFF) | autoimmune disorders | ||
| Tildrakizumab | Ilumya | mab | humanized | IL23 | Y | immunologically mediated inflammatory disorders |
| Tigatuzumab[11] | mab | humanized | TRAIL-R2 | cancer | ||
| Timigutuzumab[24] | mab | humanized | HER2 | cancer | ||
| Timolumab[31] | mab | human | AOC3 | |||
| tiragolumab[23] | mab | human | ||||
| Tiragotumab[23] | mab | human | TIGIT | cancer | ||
| Tislelizumab[23] | mab | humanized | PCDC1, CD279 | non-small cell lung cancer | ||
| Tisotumab vedotin[10] | mab | human | coagulation factor III | relapsed or refractory cervical cancer[68] | ||
| TNX-650 | ? | humanized | IL-13 | Hodgkin's lymphoma | ||
| Tocilizumab[8] | Actemra, RoActemra | mab | humanized | IL-6 receptor | Y | rheumatoid arthritis |
| Tomuzotuximab[24] | mab | humanized | epidermal growth factor receptor (EGFR), HER1 | cancer | ||
| Toralizumab[18] | mab | humanized | CD154 (CD40L) | rheumatoid arthritis, lupus nephritis etc. | ||
| Tosatoxumab[4] | mab | human | Staphylococcus aureus | |||
| Tositumomab | Bexxar | ? | mouse | CD20 | Y | follicular lymphoma |
| Tovetumab | mab | human | PDGFRA | cancer | ||
| Tralokinumab | mab | human | IL-13 | asthma, atopic dermatitis | ||
| Trastuzumab | Herceptin | mab | humanized | HER2/neu | Y | breast cancer |
| Trastuzumab duocarmazine[19] | Kadcyla | mab | humanized | HER2/neu | Y | breast cancer |
| Trastuzumab emtansine | Kadcyla | mab | humanized | HER2/neu | Y | breast cancer |
| TRBS07[69] | Ektomab | 3funct | ? | GD2 ganglioside | melanoma | |
| Tregalizumab[14] | mab | humanized | CD4 | |||
| Tremelimumab[33] | mab | human | CTLA-4 | non-small cell lung, head & neck, urothelial cancer | ||
| Trevogrumab | mab | human | growth differentiation factor 8 | muscle atrophy due to orthopedic disuse and sarcopenia | ||
| Tucotuzumab celmoleukin[40][63] | mab | humanized | EpCAM | cancer | ||
| Tuvirumab | ? | human | hepatitis B virus | chronic hepatitis B | ||
| Ublituximab[14] | mab | chimeric | MS4A1 | multiple sclerosis, chronic lymphocytic leukemia | ||
| Ulocuplumab[9] | mab | human | CXCR4 (CD184) | hematologic malignancies | ||
| Urelumab[14] | mab | human | 4-1BB (CD137) | cancer etc. | ||
| Urtoxazumab[8] | mab | humanized | Escherichia coli | diarrhoea caused by E. coli | ||
| Ustekinumab[36] | Stelara | mab | human | IL-12, IL-23 | Y | multiple sclerosis, psoriasis, psoriatic arthritis |
| Utomilumab[19] | mab | human | 4-1BB (CD137) | diffuse large B-cell lymphoma | ||
| Vadastuximab talirine[10] | mab | chimeric | CD33 | Acute myeloid leukemia | ||
| Vanalimab[5] | mab | humanized | CD40 | ? | ||
| Vandortuzumab vedotin[22] | mab | humanized | STEAP1 | cancer | ||
| Vantictumab | mab | human | Frizzled receptor | cancer | ||
| Vanucizumab[6] | mab | humanized | angiopoietin 2 | cancer | ||
| Vapaliximab[18] | mab | chimeric | AOC3 (VAP-1) | |||
| Varisacumab[24] | mab | human | VEGF-A | angiogenesis | ||
| Varlilumab[6] | mab | human | CD27 | solid tumors and hematologic malignancies | ||
| Vatelizumab[32] | mab | humanized | ITGA2 (CD49b) | |||
| Vedolizumab[61] | Entyvio | mab | humanized | integrin α4β7 | Y | Crohn's disease, ulcerative colitis |
| Veltuzumab[11] | mab | humanized | CD20 | non-Hodgkin's lymphoma | ||
| Vepalimomab | mab | mouse | AOC3 (VAP-1) | inflammation | ||
| Vesencumab[14] | mab | human | NRP1 | solid malignancies | ||
| Visilizumab[45] | Nuvion | mab | humanized | CD3 | Crohn's disease, ulcerative colitis | |
| Vobarilizumab[31] | scFv | humanized | IL6R | inflammatory autoimmune diseases | ||
| Volociximab[25] | mab | chimeric | integrin α5β1 | solid tumors | ||
| Vonlerolizumab[24] | mab | humanized | CD134 | cancer | ||
| Vopratelimab[5] | mab | humanized | CD278, aka ICOS | ? | ||
| Vorsetuzumab mafodotin | mab | humanized | CD70 | cancer | ||
| Votumumab | HumaSPECT | mab | human | tumor antigen CTAA16.88 | colorectal tumors | |
| Vunakizumab[19] | mab | humanized | interleukin 17 alpha | ? | ||
| Xentuzumab[31] | mab | humanized | IGF1, IGF2 | ? | ||
| XMAB-5574 | ? | humanized | CD19 | diffuse large B-cell lymphoma | ||
| Zalutumumab[25] | mab | human | Epidermal growth factor receptor (EGFR) | squamous cell carcinoma of the head and neck | ||
| Zanolimumab[29] | mab | human | CD4 | rheumatoid arthritis, psoriasis, T-cell lymphoma | ||
| Zatuximab[13] | mab | chimeric | HER1 | cancer | ||
| Zenocutuzumab[23] | mab | humanized | ERBB3, HER3 | cancer | ||
| Ziralimumab[45] | mab | human | CD147 (basigin) | ? | ||
| Zolbetuximab[23] (=IMAB362, Claudiximab) | mab | chimeric | Claudin 18 Isoform 2 | gastric cancer, gastrointestinal adenocarcinoma and pancreatic cancer | ||
| Zolimomab aritox | mab | mouse | CD5 | systemic lupus erythematosus, graft-versus-host disease |
References
- "United Therapeutics 10-K report". Retrieved 5 November 2011.
- World Health Organization (2006). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 95" (PDF). WHO Drug Information. 20 (2).
- World Health Organization (1998). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 80" (PDF). WHO Drug Information. 12 (4).
- World Health Organization (2013). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 109" (PDF). WHO Drug Information. 27 (2).
- World Health Organization (2017). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 118" (PDF). WHO Drug Information. 31 (4).
- World Health Organization (2014). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 111" (PDF). WHO Drug Information. 28 (2).
- World Health Organization (2001). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 85" (PDF). WHO Drug Information. 15 (2).
- World Health Organization (2004). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 90" (PDF). WHO Drug Information. 18 (1).
- World Health Organization (2013). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 110" (PDF). WHO Drug Information. 27 (4).
- World Health Organization (2015). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 113" (PDF). WHO Drug Information. 29 (2).
- World Health Organization (2007). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 98" (PDF). WHO Drug Information. 21 (4).
- World Health Organization (2000). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 83" (PDF). WHO Drug Information. 14 (2).
- World Health Organization (2012). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 107" (PDF). WHO Drug Information. 26 (2).
- World Health Organization (2010). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 104" (PDF). WHO Drug Information. 24 (4).
- World Health Organization (2002). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 86" (PDF). WHO Drug Information. 16 (1).
- World Health Organization (2016). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 115" (PDF). WHO Drug Information. 30 (2).
- "Wyeth.com | Complete Project Listing". Wyeth. 2008. Archived from the original on June 12, 2008. Retrieved November 19, 2008.
- World Health Organization (2002). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 87" (PDF). WHO Drug Information. 16 (2).
- World Health Organization (2017). "International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 77" (PDF). WHO Drug Information. 31 (1).
- World Health Organization (1995). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 74" (PDF). WHO Drug Information. 9 (4).
- World Health Organization (2003). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 88" (PDF). WHO Drug Information. 17 (1).
- World Health Organization (2014). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 112" (PDF). WHO Drug Information. 28 (4).
- World Health Organization (2017). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 117" (PDF). WHO Drug Information. 31 (2).
- World Health Organization (2016). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 116" (PDF). WHO Drug Information. 30 (4).
- World Health Organization (2008). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 93" (PDF). WHO Drug Information. 19 (2).
- World Health Organization (2019). International Nonproprietary Names (INN) for biological and biotechnological substances (PDF). World Health Organization (WHO). WHO/EMP/RHT/TSN/2019.1. Retrieved 22 January 2020.
- World Health Organization (2003). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 89" (PDF). WHO Drug Information. 17 (3).
- World Health Organization (2009). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 102" (PDF). WHO Drug Information. 23 (4).
- World Health Organization (2004). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 92" (PDF). WHO Drug Information. 18 (4).
- World Health Organization (2012). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 108" (PDF). WHO Drug Information. 26 (4).
- World Health Organization (2015). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 114" (PDF). WHO Drug Information. 29 (4).
- World Health Organization (2011). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 105" (PDF). WHO Drug Information. 25 (2).
- World Health Organization (2007). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 97" (PDF). WHO Drug Information. 21 (2).
- World Health Organization (2011). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 106" (PDF). WHO Drug Information. 25 (4).
- World Health Organization (1999). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 81" (PDF). WHO Drug Information. 13 (2).
- World Health Organization (2008). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 99" (PDF). WHO Drug Information. 22 (2).
- "BMS Shells Out $85M Up Front for Alder's Mid-Stage Rheumatoid Arthritis Antibody". Genetic Engineering & Biotechnology News. 10 November 2009.
- World Health Organization (1997). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 78" (PDF). WHO Drug Information. 11 (4).
- World Health Organization (2009). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 101" (PDF). WHO Drug Information. 23 (2).
- World Health Organization (2005). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 94" (PDF). WHO Drug Information. 19 (4).
- World Health Organization (1991). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 66" (PDF). WHO Drug Information. 5 (4).
- World Health Organization (2018). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 119" (PDF). WHO Drug Information. 32 (2).
- World Health Organization (1997). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 77" (PDF). WHO Drug Information. 11 (2).
- World Health Organization (2004). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 51" (PDF). WHO Drug Information. 18 (1).
- World Health Organization (2000). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 84" (PDF). WHO Drug Information. 14 (4).
- World Health Organization (2004). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 91" (PDF). WHO Drug Information. 18 (2).
- Buhmann, R; Simoes, B; Stanglmaier, M; Yang, T; Faltin, M; Bund, D; Lindhofer, H; Kolb, HJ; et al. (2008). "Immunotherapy of recurrent B–cell malignancies after allo SCT with Bi20 (FBTA05), a trifunctional anti-CD3 x anti-CD20 antibody and donor lymphocyte infusion". Bone Marrow Transplantation. 43 (5): 383–397. doi:10.1038/bmt.2008.323. PMID 18850012.
- Boehrer, S; Schroeder, Petra; Mueller, Tina; Atz, Judith; Chow, Kai Uwe; et al. (2011). "Cytotoxic effects of the trifunctional bispecific antibody FBTA05 in ex-vivo cells of chronic lymphocytic leukaemia depend on immune-mediated mechanisms". Anti-Cancer Drugs. 12 (10): 3085–3091. doi:10.1097/CAD.0b013e328344887f. PMID 21637160. S2CID 29327089.
- Clinical trial number NCT00883896 for "Study to Evaluate the Safety and Efficacy of ILV-094 in Subjects With Rheumatoid Arthritis" at ClinicalTrials.gov
- Clinical trial number NCT00563524 for "Study Evaluating the Safety and Tolerability of ILV-094 in Subjects With Psoriasis" at ClinicalTrials.gov
- World Health Organization (2011). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 103" (PDF). WHO Drug Information.
- "Prometheus Obtains Exclusive US Commercialization Rights for RENCAREX®".
- NCI Drug Dictionary: Glemtumumab vedotin
- "Results from Cure Brain Cancer Foundation-funded trial show promise". www.curebraincancer.org.au. Retrieved 2019-06-14.
- Clinical trial number NCT00537381 for "A Study of the Safety and Effectiveness of CNTO 95 in Patients With Metastatic Hormone Refractory Prostate Cancer" at ClinicalTrials.gov
- Clinical trial number NCT00246012 for "A Study of the Safety and Efficacy CNTO 95 in Subjects With Advanced Melanoma" at ClinicalTrials.gov
- Guthrie, Arlo (27 June 2017). "Zoetis launches breakthrough treatment for canine atopic dermatitis". VetNurse News. Retrieved 2018-07-06.
- "Margenza: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 17 December 2020.
- World Health Organization (1998). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 79" (PDF). WHO Drug Information. 12 (2).
- World Health Organization (2006). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 96" (PDF). WHO Drug Information. 20 (4).
- World Health Organization (2008). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 100 (prepublication copy)" (PDF). WHO Drug Information.
- Ruzicka, Thomas; Hanifin, Jon M.; Furue, Masutaka; Pulka, Grazyna; Mlynarczyk, Izabela; Wollenberg, Andreas; Galus, Ryszard; Etoh, Takafumi; Mihara, Ryosuke; Yoshida, Hiroki; Stewart, Jonathan; Kabashima, Kenji; XCIMA Study Group (2017). "Anti–Interleukin-31 Receptor a Antibody for Atopic Dermatitis". New England Journal of Medicine. 376 (9): 826–835. doi:10.1056/NEJMoa1606490. PMID 28249150. S2CID 205100502.
- World Health Organization (2006). "International nonproprietary names for pharmaceutical substances (INN). proposed INN: list 56" (PDF). WHO Drug Information. 20 (3).
- "FDA approves Novartis Kesimpta (ofatumumab), the first and only self-administered, targeted B-cell therapy for patients with relapsing multiple sclerosis" (Press release). Novartis. 20 August 2020. Retrieved 21 August 2020.
- World Health Organization (2017). "International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 78". WHO Drug Information. 31 (3). hdl:10665/330961.
- Xie, B.; Shen, J.; Dong, A.; Rashid, A.; Stoller, G.; Campochiaro, P. A. (2009). "Blockade of Sphingosine-1-phosphate Reduces Macrophage Influx and Retinal and Choroidal Neovascularization". Journal of Cellular Physiology. 218 (1): 192–198. doi:10.1002/jcp.21588. PMC 2905312. PMID 18781584.
- Jostein Dahle; Ada H. V. Repetto-Llamazares; Camilla S. Mollatt; Katrine B. Melhus; Oyvind S. Bruland; Arne Kolstad; Roy H. Larsen (January 2013). "Evaluating antigen targeting and anti-tumor activity of a new anti-CD37 radioimmunoconjugate against non-Hodgkin's lymphoma". Anticancer Research. 33 (1): 85–95. PMID 23267131.
- Wright, Rob (13 February 2018). "Seattle Genetics Legacy Of Partnering". Life Science Leader. Beyond The Printed Page. Retrieved 22 February 2018.
- Ruf, P; Jäger, M; Ellwart, J; Wosch, S; Kusterer, E; Lindhofer, H; et al. (2004). "Two new trifunctional antibodies for the therapy of human malignant melanoma". International Journal of Cancer. 108 (5): 725–732. doi:10.1002/ijc.11630. PMID 14696099. S2CID 25197165.
Engineered monoclonal antibodies and antibody mimetics | ||
|---|---|---|
| Whole antibody | | |
| Fab fragment | ||
| Variable fragment | ||
| Smaller units | ||
| Intracellular | ||
| Antibody mimetics | ||
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