CD200

CD200
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BFI
Identifiers
Aliases	CD200, CD200 molecule, MOX1, MOX2, MRC, OX-2, CD-200
External IDs	OMIM: 155970 MGI: 1196990 HomoloGene: 4344 GeneCards: CD200
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	112,362,812 bp[1]
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)[2]
End	45,409,053 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• receptor binding; • GO:0001948 protein binding; • protein homodimerization activity; • cell adhesion molecule binding; • protein binding involved in heterotypic cell-cell adhesion; • glycosylated region protein binding;
Cellular component	• integral component of membrane; • integral component of plasma membrane; • membrane; • cell membrane; • cell surface; • axon; • neuron projection; • neuronal cell body; • cell body;
Biological process	• heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; • cell recognition; • homophilic cell adhesion via plasma membrane adhesion molecules; • negative regulation of macrophage activation; • regulation of immune response; • negative regulation of leukocyte activation; • negative regulation of cell proliferation; • negative regulation of NF-kappaB transcription factor activity; • positive regulation of CREB transcription factor activity; • heterotypic cell-cell adhesion; • positive regulation of transforming growth factor beta production; • cell-cell adhesion; • positive regulation of arginase activity; • positive regulation of protein-glutamine gamma-glutamyltransferase activity; • regulation of neuroinflammatory response; • negative regulation of neuroinflammatory response; • negative regulation of neuron death; • negative regulation of matrix metallopeptidase secretion; • negative regulation of macrophage migration; • negative regulation of T cell migration;
	Sources:Amigo / QuickGO
Orthologs
	4345
	17470
	ENSG00000091972
	ENSMUSG00000022661
	P41217
	O54901
NM_001004196; NM_001004197; NM_005944; NM_001318826; NM_001318828;
	NM_001318830; NM_001365851; NM_001365852; NM_001365853; NM_001365854; NM_001365855
	NM_010818; NM_001358443
NP_001004196; NP_001305755; NP_001305757; NP_001305759; NP_005935;
	NP_001352780; NP_001352781; NP_001352782; NP_001352783; NP_001352784
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

OX-2 membrane glycoprotein, also named CD200 (Cluster of Differentiation 200)[5] is a human protein encoded by the CD200 gene.[6]

The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.[6]

References

GRCh38: Ensembl release 89: ENSG00000091972 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022661 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"P41217 (OX2G_HUMAN)". Uniprot. Retrieved 16 May 2013.
"Entrez Gene: CD200 CD200 molecule".

External links

CD200+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
Human CD200 genome location and CD200 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: O54901 (Mouse OX-2 membrane glycoprotein (CD200)) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000091972 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022661 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[UniprotP41217-5] "P41217 (OX2G_HUMAN)". Uniprot. Retrieved 16 May 2013.

[entrez-6] "Entrez Gene: CD200 CD200 molecule".

Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

CD200

See also

References

Further reading

External links