CCR8 (gene)

Chemokine (C-C motif) receptor 8, also known as CCR8, is a protein which in humans is encoded by the CCR8 gene.[5] CCR8 has also recently been designated CDw198 (cluster of differentiation w198).

CCR8
Identifiers
AliasesCCR8, CC-CKR-8, CCR-8, CDw198, CKRL1, CMKBR8, CMKBRL2, CY6, GPRCY6, TER1, C-C motif chemokine receptor 8
External IDsOMIM: 601834 MGI: 1201402 HomoloGene: 21080 GeneCards: CCR8
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3p22.1Start39,329,709 bp[1]
End39,333,680 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1237

12776

Ensembl

ENSG00000179934

ENSMUSG00000042262

UniProt

P51685

P56484

RefSeq (mRNA)

NM_005201

NM_007720

RefSeq (protein)

NP_005192

NP_031746

Location (UCSC)Chr 3: 39.33 – 39.33 MbChr 9: 120.09 – 120.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. The ligand of the CCR8 is CCL1.[6] CCL8 also functions as a CCR8 agonist.[7]

Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.[5]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000179934 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000042262 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CCR8 chemokine (C-C motif) receptor 8".
  6. Garlisi CG, Xiao H, Tian F, Hedrick JA, Billah MM, Egan RW, Umland SP (October 1999). "The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8". Eur. J. Immunol. 29 (10): 3210–5. doi:10.1002/(SICI)1521-4141(199910)29:10<3210::AID-IMMU3210>3.0.CO;2-W. PMID 10540332.
  7. Islam SA, Chang DS, Colvin RA, Byrne MH, McCully ML, Moser B, Lira SA, Charo IF, Luster AD (2011). "Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells". Nat. Immunol. 12 (2): 167–77. doi:10.1038/ni.1984. PMC 3863381. PMID 21217759.

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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