IL2RA

IL2RA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Z92, 2B5I, 2ERJ, 3IU3, 3NFP
Identifiers
Aliases	IL2RA, CD25, IDDM10, IL2R, TCGFR, p55, IMD41, interleukin 2 receptor subunit alpha
External IDs	OMIM: 147730 MGI: 96549 HomoloGene: 360 GeneCards: IL2RA
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	6,062,370 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	11,693,193 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• drug binding; • Ras guanyl-nucleotide exchange factor activity; • interleukin-2 receptor activity; • interleukin-2 binding; • GO:0001948 protein binding;
Cellular component	• integral component of membrane; • membrane; • cell membrane; • cell surface; • external side of plasma membrane; • intracellular; • interleukin-2 receptor complex;
Biological process	• Notch signaling pathway; • positive regulation of T cell differentiation; • regulation of T cell tolerance induction; • inflammatory response to antigenic stimulus; • negative regulation of defense response to virus; • immune system process; • activation-induced cell death of T cells; • negative regulation of lymphocyte proliferation; • MAPK cascade; • T cell homeostasis; • regulation of T cell homeostatic proliferation; • cell surface receptor signaling pathway; • negative regulation of T cell proliferation; • negative regulation of immune response; • immune response; • positive regulation of T cell proliferation; • cellular proliferation; • inflammatory response; • negative regulation of inflammatory response; • positive regulation of activated T cell proliferation; • apoptotic process; • regulation of regulatory T cell differentiation; • cytokine-mediated signaling pathway; • interleukin-2-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3559
	16184
	ENSG00000134460
	ENSMUSG00000026770
	P01589
	P01590
	NM_000417; NM_001308242; NM_001308243
	NM_008367
	NP_000408; NP_001295171; NP_001295172
	NP_032393
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-2 receptor alpha chain (also called CD25) is a protein that in humans is encoded by the IL2RA gene.[5]

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolysis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is currently unknown.[6]

Description

It is a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes. Though IL2RA has been used as a marker to identify CD4+FoxP3+ regulatory T cells in mice, it has been found that a large proportion of resting memory T cells constitutively express IL2RA in humans.[7]

IL2RA is expressed in most B-cell neoplasms, some acute nonlymphocytic leukemias, neuroblastomas, mastocytosis and tumor infiltrating lymphocytes. It functions as the receptor for HTLV-1 and is consequently expressed on neoplastic cells in adult T cell lymphoma/leukemia. Its soluble form, called sIL-2R may be elevated in these diseases and is occasionally used to track disease progression.

Clinical significance

Chagas disease

Infection by the protozoan Trypanosoma cruzi causes Chagas disease, characterized by a reduction in the amount of IL2RA expressed on the surface of immune cells. This leads to chronic immune suppression, becoming increasingly severe over the course of many years and ultimately resulting in death if left untreated.

Multiple sclerosis

The multiple sclerosis drug daclizumab binds to and blocks IL2RA.[8]

References

GRCh38: Ensembl release 89: ENSG00000134460 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026770 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Leonard WJ, Donlon TA, Lebo RV, Greene WC (Aug 1985). "Localization of the gene encoding the human interleukin-2 receptor on chromosome 10". Science. 228 (4707): 1547–9. Bibcode:1985Sci...228.1547L. doi:10.1126/science.3925551. PMID 3925551.
"Entrez Gene: IL2RA interleukin 2 receptor, alpha".
Triplett, Todd A.; et al. (July 2012). "Defining a functionally distinct subset of human memory CD4+ T cells that are CD25POS and FOXP3NEG". European Journal of Immunology. 42 (7): 1893–905. doi:10.1002/eji.201242444. PMID 22585674. S2CID 2583539.
"Zinbryta Summary of Product Characteristics" (PDF). European Medicines Agency. 2016.

External links

Mouse CD Antigen Chart
Human CD Antigen Chart
CD4+FoxP3+ regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo
Overview of all the structural information available in the PDB for UniProt: P01589 (Interleukin-2 receptor subunit alpha) at the PDBe-KB.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134460 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026770 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3925551-5] Leonard WJ, Donlon TA, Lebo RV, Greene WC (Aug 1985). "Localization of the gene encoding the human interleukin-2 receptor on chromosome 10". Science. 228 (4707): 1547–9. Bibcode:1985Sci...228.1547L. doi:10.1126/science.3925551. PMID 3925551.

[6] "Entrez Gene: IL2RA interleukin 2 receptor, alpha".

[7] Triplett, Todd A.; et al. (July 2012). "Defining a functionally distinct subset of human memory CD4+ T cells that are CD25POS and FOXP3NEG". European Journal of Immunology. 42 (7): 1893–905. doi:10.1002/eji.201242444. PMID 22585674. S2CID 2583539.

[8] "Zinbryta Summary of Product Characteristics" (PDF). European Medicines Agency. 2016.

Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350