CD84

CD84 (Cluster of Differentiation 84) is a human protein encoded by the CD84 gene.[5]

CD84
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCD84, LY9B, SLAMF5, hmCD84 molecule
External IDsOMIM: 604513 MGI: 1336885 HomoloGene: 48249 GeneCards: CD84
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q23.3Start160,541,095 bp[1]
End160,579,516 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8832

12523

Ensembl

ENSG00000066294

ENSMUSG00000038147

UniProt

Q9UIB8

Q18PI6

RefSeq (mRNA)

NM_001184879
NM_001184881
NM_001184882
NM_003874
NM_001330742

NM_001252472
NM_001289470
NM_013489

RefSeq (protein)

NP_001171808
NP_001171810
NP_001171811
NP_001317671
NP_003865

NP_001239401
NP_001276399
NP_038517

Location (UCSC)Chr 1: 160.54 – 160.58 MbChr 1: 171.84 – 171.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Members of the CD2 (see MIM 186990) subgroup of the Ig superfamily, such as CD84, have similar patterns of conserved disulfide bonds and function in adhesion interactions between T lymphocytes and accessory cells.[5]

Interactions

CD84 has been shown to interact with SH2D1A.[6][7][8][9]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000066294 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000038147 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CD84 CD84 molecule".
  6. Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC (Sep 2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation". Journal of Immunology. 171 (5): 2485–95. doi:10.4049/jimmunol.171.5.2485. PMID 12928397.
  7. Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (Jun 2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP". Blood. 97 (12): 3867–74. doi:10.1182/blood.V97.12.3867. PMID 11389028.
  8. Tangye SG, van de Weerdt BC, Avery DT, Hodgkin PD (Jun 2002). "CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2". European Journal of Immunology. 32 (6): 1640–9. doi:10.1002/1521-4141(200206)32:6<1640::AID-IMMU1640>3.0.CO;2-S. PMID 12115647.
  9. Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (Sep 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients" (PDF). The Journal of Biological Chemistry. 276 (39): 36809–16. doi:10.1074/jbc.M101305200. PMID 11477068. S2CID 39889619.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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