ADAM8
A Disintegrin and metalloproteinase domain-containing protein 8 is an enzyme that in humans is encoded by the ADAM8 gene.[5][6]
Function
This gene encodes a member of the ADAM (a disintegrin and metalloproteinase domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell–cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration.[6]
See also
References
- GRCh38: Ensembl release 89: ENSG00000151651 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000025473 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Yoshiyama K, Higuchi Y, Kataoka M, Matsuura K, Yamamoto S (April 1997). "CD156 (human ADAM8): expression, primary amino acid sequence, and gene location". Genomics. 41 (1): 56–62. doi:10.1006/geno.1997.4607. PMID 9126482.
- "Entrez Gene: ADAM8 ADAM metallopeptidase domain 8".
Further reading
- Yamamoto S, Higuchi Y, Yoshiyama K, Shimizu E, Kataoka M, Hijiya N, Matsuura K (June 1999). "ADAM family proteins in the immune system". Immunology Today. 20 (6): 278–84. doi:10.1016/S0167-5699(99)01464-4. PMID 10354553.
- Schlomann U, Rathke-Hartlieb S, Yamamoto S, Jockusch H, Bartsch JW (November 2000). "Tumor necrosis factor alpha induces a metalloprotease-disintegrin, ADAM8 (CD 156): implications for neuron-glia interactions during neurodegeneration". The Journal of Neuroscience. 20 (21): 7964–71. doi:10.1523/JNEUROSCI.20-21-07964.2000. PMC 6772711. PMID 11050116.
- Amour A, Knight CG, English WR, Webster A, Slocombe PM, Knäuper V, Docherty AJ, Becherer JD, Blobel CP, Murphy G (July 2002). "The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs". FEBS Letters. 524 (1–3): 154–8. doi:10.1016/S0014-5793(02)03047-8. PMID 12135759. S2CID 37423323.
- Ishikawa N, Daigo Y, Yasui W, Inai K, Nishimura H, Tsuchiya E, Kohno N, Nakamura Y (December 2004). "ADAM8 as a novel serological and histochemical marker for lung cancer". Clinical Cancer Research. 10 (24): 8363–70. doi:10.1158/1078-0432.CCR-04-1436. PMID 15623614.
- Foley SC, Mogas AK, Olivenstein R, Fiset PO, Chakir J, Bourbeau J, Ernst P, Lemière C, Martin JG, Hamid Q (April 2007). "Increased expression of ADAM33 and ADAM8 with disease progression in asthma". The Journal of Allergy and Clinical Immunology. 119 (4): 863–71. doi:10.1016/j.jaci.2006.12.665. PMID 17339047.
- Gómez-Gaviro M, Domínguez-Luis M, Canchado J, Calafat J, Janssen H, Lara-Pezzi E, Fourie A, Tugores A, Valenzuela-Fernández A, Mollinedo F, Sánchez-Madrid F, Díaz-González F (June 2007). "Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding". Journal of Immunology. 178 (12): 8053–63. doi:10.4049/jimmunol.178.12.8053. PMID 17548643.
- Valkovskaya N, Kayed H, Felix K, Hartmann D, Giese NA, Osinsky SP, Friess H, Kleeff J (2008). "ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer". Journal of Cellular and Molecular Medicine. 11 (5): 1162–74. doi:10.1111/j.1582-4934.2007.00082.x. PMC 4401277. PMID 17979891.
External links
- The MEROPS online database for peptidases and their inhibitors: M12.208
- ADAM8 human gene location in the UCSC Genome Browser.
- ADAM8 human gene details in the UCSC Genome Browser.
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8)
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