C-C chemokine receptor type 7

C-C chemokine receptor type 7 is a protein that in humans is encoded by the CCR7 gene.[5] Two ligands have been identified for this receptor: the chemokines (C-C motif) ligand 19 (CCL19/ELC) and (C-C motif) ligand 21 (CCL21).[6]

CCR7
Identifiers
AliasesCCR7, BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1, C-C motif chemokine receptor 7
External IDsOMIM: 600242 MGI: 103011 HomoloGene: 1387 GeneCards: CCR7
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q21.2Start40,553,769 bp[1]
End40,565,472 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1236

12775

Ensembl

ENSG00000126353

ENSMUSG00000037944

UniProt

P32248

P47774

RefSeq (mRNA)

NM_001838
NM_001301714
NM_001301716
NM_001301717
NM_001301718

NM_001301713
NM_007719

RefSeq (protein)

NP_001288643
NP_001288645
NP_001288646
NP_001288647
NP_001829

NP_001288642
NP_031745

Location (UCSC)Chr 17: 40.55 – 40.57 MbChr 11: 99.14 – 99.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CCR7 has also recently been designated CD197 (cluster of differentiation 197).

Function

The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. CCR7 has been shown to stimulate dendritic cell maturation. CCR7 is also involved in homing of T cells to various secondary lymphoid organs such as lymph nodes and the spleen as well as trafficking of T cells within the spleen.[7]

Activation of Dendritic cells in peripheral tissues induces CCR7 expression on the cell's surface, which recognize CCL19 and CCL21 produced in the Lymph node and increases dendritic cell expression of co-stimulation molecules (B7), and MHC class I or MHC class II.[8]

Clinical significance

CCR7 is expressed by various cancer cells, such as nonsmall lung cancer, gastric cancer and oesophageal cancer.[9][10][11] Expression of CCR7 by cancer cells is linked with metastasis to lymph nodes.[12]

References
  1. GRCh38: Ensembl release 89: ENSG00000126353 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037944 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Birkenbach M, Josefsen K, Yalamanchili R, Lenoir G, Kieff E (Apr 1993). "Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors". Journal of Virology. 67 (4): 2209–20. doi:10.1128/JVI.67.4.2209-2220.1993. PMC 240341. PMID 8383238.
  6. F. Balkwill, Cancer and the Chemokine Network, Nature reviews, 2004
  7. Sharma N, Benechet AP, Lefrançois L, Khanna KM (Dec 2015). "CD8 T Cells Enter the Splenic T Cell Zones Independently of CCR7, but the Subsequent Expansion and Trafficking Patterns of Effector T Cells after Infection Are Dysregulated in the Absence of CCR7 Migratory Cues". Journal of Immunology. 195 (11): 5227–5236. doi:10.4049/jimmunol.1500993. PMC 4655190. PMID 26500349.
  8. Riol-Blanco L, Sánchez-Sánchez N, Torres A, Tejedor A, Narumiya S, Corbí AL, Sánchez-Mateos P, Rodríguez-Fernández JL (Apr 2005). "The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed". Journal of Immunology. 174 (7): 4070–80. doi:10.4049/jimmunol.174.7.4070. PMID 15778365.
  9. Mashino K, Sadanaga N, Yamaguchi H, Tanaka F, Ohta M, Shibuta K, Inoue H, Mori M (May 2002). "Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma". Cancer Research. 62 (10): 2937–41. PMID 12019175.
  10. Takanami I (Jun 2003). "Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph node metastasis". International Journal of Cancer. 105 (2): 186–9. doi:10.1002/ijc.11063. PMID 12673677. S2CID 1523901.
  11. Ding Y, Shimada Y, Maeda M, Kawabe A, Kaganoi J, Komoto I, Hashimoto Y, Miyake M, Hashida H, Imamura M (Aug 2003). "Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma". Clinical Cancer Research. 9 (9): 3406–12. PMID 12960129.
  12. Shields JD, Fleury ME, Yong C, Tomei AA, Randolph GJ, Swartz MA (Jun 2007). "Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling" (PDF). Cancer Cell. 11 (6): 526–38. doi:10.1016/j.ccr.2007.04.020. PMID 17560334.

Further reading

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