CD248

Endosialin is a protein that in humans is encoded by the CD248 gene.[5][6][7]

CD248
Identifiers
AliasesCD248, CD164L1, TEM1, CD248 molecule
External IDsOMIM: 606064 MGI: 1917695 HomoloGene: 10699 GeneCards: CD248
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.2Start66,314,494 bp[1]
End66,317,044 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

57124

70445

Ensembl

ENSG00000174807

ENSMUSG00000056481

UniProt

Q9HCU0

Q91V98

RefSeq (mRNA)

NM_020404

NM_054042

RefSeq (protein)

NP_065137

NP_473383

Location (UCSC)Chr 11: 66.31 – 66.32 MbChr 19: 5.07 – 5.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Endosialin is a member of the “Group XIV”, a novel family of C-type lectin transmembrane receptors which play a role not only in cell–cell adhesion processes but also in host defence. This family comprise three other members, CLEC14A, CD93 and Thrombomodulin the latter of which are better characterized. [8]

The function of endosialin remains elusive, but its expression has been associated with angiogenesis in the embryo and uterus and in tumor development and growth.[9]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000174807 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000056481 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW (Aug 2000). "Genes expressed in human tumor endothelium". Science. 289 (5482): 1197–202. Bibcode:2000Sci...289.1197S. doi:10.1126/science.289.5482.1197. PMID 10947988.
  6. Christian S, Ahorn H, Koehler A, Eisenhaber F, Rodi HP, Garin-Chesa P, Park JE, Rettig WJ, Lenter MC (May 2001). "Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium". J Biol Chem. 276 (10): 7408–14. doi:10.1074/jbc.M009604200. PMID 11084048.
  7. "Entrez Gene: CD248 CD248 molecule, endosialin".
  8. Khan KA, McMurray J, Mohammed FM, Bicknell R (2019). "C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation". FEBS Journal. 286 (17): 3299–3332. doi:10.1111/febs.14985. PMC 6852297. PMID 31287944.
  9. Rupp C, Dolznig H, Puri C, Sommergruber W, Kerjaschki D, Rettig WJ, Garin-Chesa P (2006). "Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis". Cancer Immun. 6: 10. PMID 16875435.

Further reading



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