ICOSLG

ICOS ligand is a protein that in humans is encoded by the ICOSLG gene.[5][6][7] ICOSLG has also been designated as CD275 (cluster of differentiation 275).

ICOSLG
Identifiers
AliasesICOSLG, B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS, inducible T-cell co-stimulator ligand, inducible T-cell costimulator ligand, inducible T cell costimulator ligand, B7h
External IDsOMIM: 605717 MGI: 1354701 HomoloGene: 49412 GeneCards: ICOSLG
Gene location (Human)
Chr.Chromosome 21 (human)[1]
Band21q22.3Start44,217,014 bp[1]
End44,240,966 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23308

50723

Ensembl

ENSG00000160223

ENSMUSG00000000732

UniProt

O75144

Q9JHJ8

RefSeq (mRNA)

NM_001283050
NM_001283051
NM_001283052
NM_015259
NM_001365759

NM_015790

RefSeq (protein)

NP_001269979
NP_001269980
NP_001269981
NP_056074
NP_001352688

NP_056605

Location (UCSC)Chr 21: 44.22 – 44.24 MbChr 10: 78.07 – 78.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000160223 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000000732 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  6. Yoshinaga SK, Zhang M, Pistillo J, Horan T, Khare SD, Miner K, Sonnenberg M, Boone T, Brankow D, Dai T, Delaney J, Han H, Hui A, Kohno T, Manoukian R, Whoriskey JS, Coccia MA (October 2000). "Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS". International Immunology. 12 (10): 1439–47. doi:10.1093/intimm/12.10.1439. PMID 11007762.
  7. "Entrez Gene: ICOSLG inducible T-cell co-stimulator ligand".

Further reading


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