LILRB1

LILRB1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1G0X, 1P7Q, 1UFU, 1UGN, 1VDG, 3D2U, 4LL9, 4NO0
Identifiers
Aliases	LILRB1, CD85J, ILT-2, ILT2, LIR-1, LIR1, MIR-7, MIR7, PIR-B, PIRB, leukocyte immunoglobulin like receptor B1
External IDs	OMIM: 604811 HomoloGene: 88463 GeneCards: LILRB1
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	54,637,528 bp[1]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• protein homodimerization activity; • MHC class I receptor activity; • SH2 domain binding; • protein phosphatase 1 binding; • HLA-A specific inhibitory MHC class I receptor activity; • HLA-B specific inhibitory MHC class I receptor activity; • MHC class I protein binding; • amyloid-beta binding; • GO:0001948 protein binding; • MHC class Ib receptor activity; • MHC class Ib protein complex binding; • MHC class Ib protein binding;
Cellular component	• cytoplasm; • integral component of membrane; • membrane; • cell membrane; • extracellular region; • external side of plasma membrane;
Biological process	• negative regulation of endocytosis; • dendritic cell differentiation; • negative regulation of mononuclear cell proliferation; • negative regulation of interferon-gamma production; • adaptive immune response; • Fc receptor mediated inhibitory signaling pathway; • negative regulation of osteoclast development; • immune system process; • response to virus; • receptor internalization; • negative regulation of cell cycle; • GO:0002719 negative regulation of cytokine production involved in immune response; • negative regulation of serotonin secretion; • T cell proliferation involved in immune response; • negative regulation of alpha-beta T cell activation; • negative regulation of T cell mediated cytotoxicity; • positive regulation of cytolysis; • negative regulation of T cell proliferation; • positive regulation of gene expression; • defense response to virus; • negative regulation of calcium ion transport; • regulation of immune response; • positive regulation of apoptotic process; • negative regulation of natural killer cell mediated cytotoxicity; • negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; • interferon-gamma production; • cellular response to lipopolysaccharide; • immune response-inhibiting cell surface receptor signaling pathway; • positive regulation of gamma-delta T cell activation involved in immune response; • negative regulation of dendritic cell apoptotic process; • negative regulation of dendritic cell differentiation; • signal transduction; • positive regulation of transcription from RNA polymerase II promoter; • negative regulation of CD8-positive, alpha-beta T cell activation; • positive regulation of defense response to virus by host; • positive regulation of macrophage cytokine production;
	Sources:Amigo / QuickGO
Orthologs
	10859
	n/a
ENSG00000104972; ENSG00000276452; ENSG00000277134; ENSG00000274669; ENSG00000277807;
	n/a
	n/a
	Q8NHL6
	n/a
NM_001081637; NM_001081638; NM_001081639; NM_001278398; NM_001278399;
	NM_006669
	n/a
NP_001075106; NP_001075107; NP_001075108; NP_001265327; NP_001265328;
	NP_006660
	n/a
	Wikidata
View/Edit Human

Leukocyte immunoglobulin-like receptor subfamily B member 1 is a protein that in humans is encoded by the LILRB1 gene.[3][4]

Function

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.[5]

References

ENSG00000276452, ENSG00000277134, ENSG00000274669, ENSG00000277807 GRCh38: Ensembl release 89: ENSG00000104972, ENSG00000276452, ENSG00000277134, ENSG00000274669, ENSG00000277807 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Cosman D, Fanger N, Borges L, Kubin M, Chin W, Peterson L, Hsu ML (Aug 1997). "A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules". Immunity. 7 (2): 273–82. doi:10.1016/S1074-7613(00)80529-4. PMID 9285411.
Colonna M, Navarro F, Bellón T, Llano M, García P, Samaridis J, Angman L, Cella M, López-Botet M (Dec 1997). "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells". The Journal of Experimental Medicine. 186 (11): 1809–18. doi:10.1084/jem.186.11.1809. PMC 2199153. PMID 9382880.
"Entrez Gene: LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1".

External links

LILRB1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] ENSG00000276452, ENSG00000277134, ENSG00000274669, ENSG00000277807 GRCh38: Ensembl release 89: ENSG00000104972, ENSG00000276452, ENSG00000277134, ENSG00000274669, ENSG00000277807 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9285411-3] Cosman D, Fanger N, Borges L, Kubin M, Chin W, Peterson L, Hsu ML (Aug 1997). "A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules". Immunity. 7 (2): 273–82. doi:10.1016/S1074-7613(00)80529-4. PMID 9285411.

[pmid9382880-4] Colonna M, Navarro F, Bellón T, Llano M, García P, Samaridis J, Angman L, Cella M, López-Botet M (Dec 1997). "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells". The Journal of Experimental Medicine. 186 (11): 1809–18. doi:10.1084/jem.186.11.1809. PMC 2199153. PMID 9382880.

[entrez-5] "Entrez Gene: LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1".

Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

LILRB1

Function

See also

References

Further reading

External links