PTGFRN

PTGFRN
Identifiers
Aliases	PTGFRN, CD315, CD9P-1, EWI-F, FPRP, SMAP-6, prostaglandin F2 receptor inhibitor
External IDs	OMIM: 601204 MGI: 1277114 HomoloGene: 7908 GeneCards: PTGFRN
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	116,990,353 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	101,110,278 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding;
Cellular component	• cell surface; • Golgi apparatus; • endoplasmic reticulum membrane; • endoplasmic reticulum; • membrane; • cell membrane; • integral component of membrane;
Biological process	• lipid particle organization; • myoblast fusion involved in skeletal muscle regeneration;
	Sources:Amigo / QuickGO
Orthologs
	5738
	19221
	ENSG00000134247
	ENSMUSG00000027864
	Q9P2B2
	Q9WV91
	NM_020440
	NM_011197
	NP_065173
	NP_035327
	Wikidata
View/Edit Human	View/Edit Mouse

Prostaglandin F2 receptor negative regulator is a protein that in humans is encoded by the PTGFRN gene.[5][6] PTGFRN has also been designated as CD315 (cluster of differentiation 315).

Interactions

PTGFRN has been shown to interact with CD9[7][8] and CD81.[7][8]

References

GRCh38: Ensembl release 89: ENSG00000134247 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000027864 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Orlicky DJ, Berry R, Sikela JM (Jul 1996). "Human chromosome 1 localization of the gene for a prostaglandin F2alpha receptor negative regulatory protein". Hum Genet. 97 (5): 655–8. doi:10.1007/BF02281878. PMID 8655148. S2CID 21645802.
"Entrez Gene: PTGFRN prostaglandin F2 receptor negative regulator".
Charrin, S; Le Naour F; Oualid M; Billard M; Faure G; Hanash S M; Boucheix C; Rubinstein E (Apr 2001). "The major CD9 and CD81 molecular partner. Identification and characterization of the complexes". J. Biol. Chem. United States. 276 (17): 14329–37. doi:10.1074/jbc.M011297200. ISSN 0021-9258. PMID 11278880.
Stipp, C S; Orlicky D; Hemler M E (Feb 2001). "FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein". J. Biol. Chem. United States. 276 (7): 4853–62. doi:10.1074/jbc.M009859200. ISSN 0021-9258. PMID 11087758.

Orlicky DJ (1997). "Negative regulatory activity of a prostaglandin F2 alpha receptor associated protein (FPRP)". Prostaglandins Leukot. Essent. Fatty Acids. 54 (4): 247–59. doi:10.1016/S0952-3278(96)90055-1. PMID 8804121.
Orlicky DJ, Lieber JG, Morin CL, Evans RM (1998). "Synthesis and accumulation of a receptor regulatory protein associated with lipid droplet accumulation in 3T3-L1 cells". J. Lipid Res. 39 (6): 1152–61. PMID 9643346.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Stipp CS, Orlicky D, Hemler ME (2001). "FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein". J. Biol. Chem. 276 (7): 4853–62. doi:10.1074/jbc.M009859200. PMID 11087758.
Charrin S, Le Naour F, Oualid M, et al. (2001). "The major CD9 and CD81 molecular partner. Identification and characterization of the complexes". J. Biol. Chem. 276 (17): 14329–37. doi:10.1074/jbc.M011297200. PMID 11278880.
Clark KL, Zeng Z, Langford AL, et al. (2001). "PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins". J. Immunol. 167 (9): 5115–21. doi:10.4049/jimmunol.167.9.5115. PMID 11673522.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Yang XH, Kovalenko OV, Kolesnikova TV, et al. (2006). "Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization". J. Biol. Chem. 281 (18): 12976–85. doi:10.1074/jbc.M510617200. PMID 16537545.
Sala-Valdés M, Ursa A, Charrin S, et al. (2006). "EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins". J. Biol. Chem. 281 (28): 19665–75. doi:10.1074/jbc.M602116200. PMID 16690612.

External links

PTGFRN+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134247 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027864 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8655148-5] Orlicky DJ, Berry R, Sikela JM (Jul 1996). "Human chromosome 1 localization of the gene for a prostaglandin F2alpha receptor negative regulatory protein". Hum Genet. 97 (5): 655–8. doi:10.1007/BF02281878. PMID 8655148. S2CID 21645802.

[entrez-6] "Entrez Gene: PTGFRN prostaglandin F2 receptor negative regulator".

[pmid11278880-7] Charrin, S; Le Naour F; Oualid M; Billard M; Faure G; Hanash S M; Boucheix C; Rubinstein E (Apr 2001). "The major CD9 and CD81 molecular partner. Identification and characterization of the complexes". J. Biol. Chem. United States. 276 (17): 14329–37. doi:10.1074/jbc.M011297200. ISSN 0021-9258. PMID 11278880.

[pmid11087758-8] Stipp, C S; Orlicky D; Hemler M E (Feb 2001). "FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein". J. Biol. Chem. United States. 276 (7): 4853–62. doi:10.1074/jbc.M009859200. ISSN 0021-9258. PMID 11087758.

Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

PTGFRN

Interactions

References

Further reading

External links