Testosterone palmitate
Testosterone palmitate, also known as testosterone hexadecanoate, testosterone 17β-palmitate, and androst-4-en-17β-ol-3-one 17β-palmitate, is an anabolic-androgenic steroid (AAS) and an androgen ester – specifically, the C17β palmitate (hexadecanoate) ester of testosterone – which was never marketed.[1][2][3] It is a prodrug of testosterone and, when administered via intramuscular injection, is associated with a long-lasting depot effect and extended duration of action.[1]
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| Other names | Testosterone hexadecanoate; Testosterone 17β-palmitate; Androst-4-en-17β-ol-3-one 17β-palmitate |
| Routes of administration | Oral, intramuscular injection |
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| Formula | C35H58O3 |
| Molar mass | 526.846 g·mol−1 |
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Testosterone palmitate is a longer-chain ester of testosterone compared to testosterone undecanoate.[1] Relative to testosterone undecanoate, testosterone palmitate shows higher oral bioavailability.[1] However, no free testosterone was observed after administration of testosterone palmitate, suggesting that it is not hydrolyzed as well.[1] On the other hand, another study found that testosterone palmitate was hydrolyzed in humans.[4]
See also
References
- Touitou E, Barry BW (27 November 2006). Enhancement in Drug Delivery. CRC Press. pp. 122–. ISBN 978-1-4200-0481-6.
- Josephy E, Radt F (1 December 2013). Elsevier's Encyclopaedia of Organic Chemistry: Series III: Carboisocyclic Condensed Compounds. Springer. pp. 3048–. ISBN 978-3-662-25863-7.
- United States. Environmental Protection Agency. Office of Toxic Substances (1977). Toxic Substances Control Act (TSCA): PL 94-469 : Candidate List of Chemical Substances. Environmental Protection Agency, Office of Toxic Substances. pp. 315–.
- Dissertation Abstracts International: The sciences and engineering. University Microfilms. 1990. p. 4857.