Langerin

CD207, langerin (Cluster of Differentiation 207) is a protein which in humans is encoded by the CD207 gene.[5][6] Langerin is a type II transmembrane, C-type lectin receptor on Langerhans cells.[6][7]

CD207
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCD207, CLEC4K, CD207 molecule
External IDsOMIM: 604862 MGI: 2180021 HomoloGene: 9252 GeneCards: CD207
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p13.3Start70,830,211 bp[1]
End70,835,816 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

50489

246278

Ensembl

ENSG00000116031

ENSMUSG00000034783

UniProt

Q9UJ71

Q8VBX4

RefSeq (mRNA)

NM_015717

NM_144943

RefSeq (protein)

NP_056532

NP_659192

Location (UCSC)Chr 2: 70.83 – 70.84 MbChr 6: 83.67 – 83.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is expressed in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. Additionally it is known by the name C-type lectin domain family 4 member K (CD antigen CD207). It is also expressed in several other dendritic cell types including dermal CD103+ DCs and splenic CD8+ DCs. Langerin is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway.[5]

Clinical significance

Langerin on mucosal Langerhans cells of the human genital epithelium binds to HIV-1 and subsequently internalizes it into Birbeck granules to be degraded.[8][9]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000116031 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000034783 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. EntrezGene 50489
  6. Valladeau J; Ravel O; Dezutter-Dambuyant C; Moore K; Kleijmeer M; Liu Y; Duvert-Frances Vé; Vincent C; Schmitt D (2000). "Langerin, a Novel C-Type Lectin Specific to Langerhans Cells, is an Endocytic Receptor that Induces the Formation of Birbeck Granules". Immunity. 12 (1): 71–81. doi:10.1016/S1074-7613(00)80160-0. PMID 10661407.
  7. Valladeau J; Clair-Moninot Vé; Dezutter-Dambuyant C; Pin J-J; Kissenpfennig A; Mattéi M-G; Ait-Yahia S; Bates EEM; Malissen B (2002). "Identification of Mouse Langerin/CD207 in Langerhans Cells and Some Dendritic Cells of Lymphoid Tissues". Journal of Immunology. 168 (2): 782–92. doi:10.4049/jimmunol.168.2.782. PMID 11777972.
  8. De Witte L; Nabatov A; Pion M; Fluitsma D; De Jong MAWP; De Gruijl T; Piguet V; Van Kooyk Y; Geijtenbeek TBH (2007). "Langerin is a natural barrier to HIV-1 transmission by Langerhans cells". Nature Medicine. 13 (3): 367–71. doi:10.1038/nm1541. PMID 17334373. S2CID 5090679.
  9. Turville S, Wilkinson J, Cameron P, Dable J, Cunningham AL (2003). "The role of dendritic cell C-type lectin receptors in HIV pathogenesis". Journal of Leukocyte Biology. 74 (5): 710–8. doi:10.1189/jlb.0503208. PMID 12960229. S2CID 44539239.

Further reading


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