Naloxonazine

Naloxonazine is a potent, irreversible μ-opioid receptor antagonist.[1] Naloxonazine forms spontaneously in acidic solutions of naloxazone, and may be responsible for much or all of the irreversible μ opioid receptor binding displayed by the latter.[2]

Naloxonazine
Names
Other names
NIH 10894; NSC 612113, Bis-[5-α-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)-morphinan-6-ylidene] hydrazine dihydrochloride
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
Properties
C38H42N4O6
Molar mass 650.776 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

See also

References
  1. Naloxonazine dihydrochloride
  2. Hahn, E. F.; Pasternak, G. W. (September 1982). "Naloxonazine, a potent, long-lasting inhibitor of opiate binding sites". Life Sciences. 31 (12–13): 1385–1388. doi:10.1016/0024-3205(82)90387-3. PMID 6292633.



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