Ibogamine

Ibogamine is an anti-convulsant, anti-addictive CNS stimulant alkaloid found in Tabernanthe iboga and Crepe Jasmine (Tabernaemontana divaricata).[1][2][3][4] Basic research related to how addiction affects the brain has used this chemical.[5]

Ibogamine
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
ChEBI
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H24N2
Molar mass280.415 g·mol−1
3D model (JSmol)
 NY (what is this?)  (verify)

Ibogamine persistently reduced the self-administration of cocaine and morphine in rats.[6] The same study found that ibogamine (40 mg/kg) and coronaridine (40 mg/kg) did not produce "any tremor effects in rats that differ significantly from saline control". While the related alkaloids ibogaine (20–40 mg/kg), harmaline (10–40 mg/kg) and desethylcoronaridine (10–40 mg/kg) were "obviously tremorgenic".[6]

Pharmacology

It blocks nicotinic acetylcholine receptor at neuromuscular junction. It also blocks kappa receptor,N-nethyl-D-asparate receptor. It also has effect on serotonin sites.[7] It also inhibits acetycholinestearase and butrylcholinestearase[8]

See also

References
  1. http://medind.nic.in/iby/t08/i4/ibyt08i4p317.pdf
  2. Bartlett, M. F.; Dickel, D. F.; Taylor, W. I. (1958). "The Alkaloids of Tabernanthe iboga. Part IV.1 The Structures of Ibogamine, Ibogaine, Tabernanthine and Voacangine". Journal of the American Chemical Society. 80 (1): 126–136. doi:10.1021/ja01534a036.
  3. Kuehne, Martin E.; Reider, Paul J. (1985). "A synthesis of ibogamine". The Journal of Organic Chemistry. 50 (9): 1464–1467. doi:10.1021/jo00209a020.
  4. http://www.ijrrjournal.com/IJRR_Vol.6_Issue.8_Aug2019/IJRR0067.pdf
  5. Levi MS, Borne RF (October 2002). "A review of chemical agents in the pharmacotherapy of addiction". Curr. Med. Chem. 9 (20): 1807–18. doi:10.2174/0929867023368980. PMID 12369879.
  6. Glick SD, Kuehne ME, Raucci J, Wilson TE, Larson D, Keller RW Jr, Carlson JN (September 1994). "Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum". Brain Res. 657 (1–2): 14–22. doi:10.1016/0006-8993(94)90948-2. PMID 7820611.
  7. https://www.thefreelibrary.com/Ethnobotany+%26+ethnopharmacology+of+Tabernaemontana+divaricata.-a0181406119
  8. "Annals of the Brazilian Academy of Sciences" (PDF).



This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.