Spiroxatrine

Spiroxatrine
Names
	IUPAC name 8-(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Identifiers
CAS Number	1054-88-2 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL300555 ;
ChemSpider	5078 ;
IUPHAR/BPS	53;
MeSH	Spiroxatrine
PubChem CID	5268;
UNII	DR0QR50ALL ;
CompTox Dashboard (EPA)	DTXSID3045198 ;
	InChI InChI=1S/C22H25N3O3/c26-21-22(25(16-23-21)17-6-2-1-3-7-17)10-12-24(13-11-22)14-18-15-27-19-8-4-5-9-20(19)28-18/h1-9,18H,10-16H2,(H,23,26) Key: JVGBTTIJPBFLTE-UHFFFAOYSA-N ;
	SMILES O=C2NCN(c1ccccc1)C23CCN(CC3)CC4Oc5ccccc5OC4;
Properties
Chemical formula	C22H25N3O3
Molar mass	379.460 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Spiroxatrine is a drug which acts as a selective antagonist at both the 5-HT_1A receptor and the α_2C adrenergic receptor.[1] It is an analog of spiperone and also has some dopamine antagonist effects.

References

Terrón, J. A.; Ibarra, M; Ransanz, V; Hong, E; Villalón, C. M. (1993). "The alpha-antiadrenergic properties of spiroxatrine, a ligand of serotonergic 5-HT1A receptors". Archivos del Instituto de Cardiología de México. 63 (4): 289–95. PMID 8105762.

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