Butaclamol
Butaclamol (AY-23,028) is a typical antipsychotic which was never marketed.[1] Sold as the hydrochloride salt for use in research, the compound acts as a dopamine receptor antagonist.[2]
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| Formula | C25H31NO |
| Molar mass | 361.529 g·mol−1 |
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Chemistry
pKa = 7.15 (uncorrected for ionic strength)[3]
References
- Buckingham J (1985). Dictionary of organic compounds - Google Books. ISBN 978-0-412-54090-5.
- Hall DA, Strange PG (June 1997). "Evidence that antipsychotic drugs are inverse agonists at D2 dopamine receptors". British Journal of Pharmacology. 121 (4): 731–6. doi:10.1038/sj.bjp.0701196. PMC 1564749. PMID 9208141.
- Chrzanowski FA, McGrogan BA, Maryanoff BE (March 1985). "The pKa of butaclamol and the mode of butaclamol binding to central dopamine receptors". Journal of Medicinal Chemistry. 28 (3): 399–400. doi:10.1021/jm00381a022. PMID 2579238.
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See also: Receptor/signaling modulators | |
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| Antidepressants (TCAs and TeCAs) |
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