Metitepine
Metitepine (INN; developmental code names Ro 8-6837 (maleate), VUFB-6276 (mesylate)), also known as methiothepin, is a drug described as a "psychotropic agent" of the tricyclic group which was never marketed.[1] It acts as a non-selective antagonist of serotonin, dopamine, and adrenergic receptors[2][3][4] and has antipsychotic properties.[5]
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Other names | Methiothepin; Methiothepine; Ro 8-6837 (maleate); VUFB-6276 (mesylate) |
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ECHA InfoCard | 100.261.496 ![]() |
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Formula | C20H24N2S2 |
Molar mass | 356.55 g·mol−1 |
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See also
References
- J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 815–. ISBN 978-1-4757-2085-3.
- Monachon MA, Burkard WP, Jalfre M, Haefely W (1972). "Blockade of central 5-hydroxytryptamine receptors by methiothepin". Naunyn Schmiedebergs Arch. Pharmacol. 274 (2): 192–7. doi:10.1007/BF00501854. PMID 4340797.
- Dall'Olio R, Vaccheri A, Montanaro N (1985). "Reduced head-twitch response to quipazine of rats previously treated with methiothepin: possible involvement of dopaminergic system". Pharmacol. Biochem. Behav. 23 (1): 43–8. doi:10.1016/0091-3057(85)90128-5. PMID 2994121.
- Roth, BL; Driscol, J. "PDSP Ki Database". Psychoactive Drug Screening Program (PDSP). University of North Carolina at Chapel Hill and the United States National Institute of Mental Health. Retrieved 14 August 2017.
- Thomas L. Lemke; David A. Williams (24 January 2012). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. pp. 388–. ISBN 978-1-60913-345-0.
External links
- Methiothepin at the US National Library of Medicine Medical Subject Headings (MeSH)
5-HT1 |
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Antidepressants (TCAs and TeCAs) |
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