Licarbazepine
Licarbazepine is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects that is related to oxcarbazepine.[1] It is an active metabolite of oxcarbazepine.[1][2] In addition, an enantiomer of licarbazepine, eslicarbazepine ((S)-(+)-licarbazepine), is an active metabolite of eslicarbazepine acetate.[1][2] Oxcarbazepine and eslicarbazepine acetate are inactive on their own, and behave instead as prodrugs to licarbazepine and eslicarbazepine, respectively, to produce their therapeutic effects.[1][2]
![]() Top: (R)-(−)-licarbazepine Bottom: (S)-(+)-licarbazepine | |
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Pharmacokinetic data | |
Protein binding | <40% |
Metabolites | Glucuronides |
Excretion | Mainly renal |
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ECHA InfoCard | 100.122.427 ![]() |
Chemical and physical data | |
Formula | C15H14N2O2 |
Molar mass | 254.289 g·mol−1 |
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Chirality | Racemic mixture |
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References
- Singh RP, Asconapé JJ (2011). "A review of eslicarbazepine acetate for the adjunctive treatment of partial-onset epilepsy". Journal of Central Nervous System Disease. 3: 179–87. doi:10.4137/JCNSD.S4888. PMC 3663619. PMID 23861647.
- Bialer M, Soares-da-Silva P (June 2012). "Pharmacokinetics and drug interactions of eslicarbazepine acetate". Epilepsia. 53 (6): 935–46. doi:10.1111/j.1528-1167.2012.03519.x. PMID 22612290. S2CID 21233948.
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Ion channel blockers |
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Calcium |
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Sodium |
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See also: Receptor/signaling modulators • Transient receptor potential channel modulators |
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Antidepressants (TCAs and TeCAs) |
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Antihistamines |
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Antipsychotics |
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Anticonvulsants | |
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