Ranolazine

Ranolazine is used to treat chronic angina.[5] It may be used concomitantly with β blockers, nitrates, calcium channel blockers, antiplatelet therapy, lipid-lowering therapy, ACE inhibitors, and angiotensin receptor blockers.[6]

Its use is not recommended in Scotland as of 2019.[2]

Some contraindications for ranolazine are related to its metabolism and are described under Drug Interactions. Additionally, in clinical trials ranolazine slightly increased QT interval in some patients[7] and the FDA label contains a warning for doctors to beware of this effect in their patients.[6] The drug's effect on the QT interval is increased in the setting of liver dysfunction; thus it is contraindicated in persons with mild to severe liver disease.[8]

The most common side effects are dizziness (11.5%) and constipation (10.9%).[5] Other side effects include headache and nausea.[7]

Ranolazine is metabolized mainly by the CYP3A enzyme. It also inhibits another metabolizing enzyme, cytochrome CYP2D6.[6] For this reason, the doses of ranolazine and drugs that interact with those enzymes need to be adjusted when they are used by the same patient.

Ranolazine should not be used with drugs such as ketoconazole, clarithromycin, and nelfinavir that strongly inhibit CYP3A, nor with drugs that activate CYP3A, such as rifampin and phenobarbital.[6]

For drugs that are moderate CYP3A inhibitors, such as diltiazem, verapamil, and erythromycin, the dose of ranolazine should be reduced.[6]

Drugs that are metabolized by CYP2D6, such as tricyclic antidepressants, may need to be given at reduced doses when administered with ranolazine.[6]

Ranolazine inhibits persistent or late inward sodium current (I_Na) in heart muscle[9] in a variety of voltage-gated sodium channels.[10] Inhibiting that current leads to reductions in intracellular calcium levels. This in turn leads to reduced tension in the heart wall, leading to reduced oxygen requirements for the muscle.[7] The QT prolongation effect of ranolazine on the surface electrocardiogram is the result of inhibition of I_Kr, which prolongs the ventricular action potential.[6] Ranolazine also exhibits its effects on the delayed rectifier current (hERG/I_Kr potassium channels), it readily stimulates myogenesis, it reduces a pro-oxidant inflammation/oxidative condition, and activates the calcium signaling pathway.[11]

Ranolazine prolongs the action potential duration, with corresponding QT interval prolongation on electrocardiography, blocks the I_Na current, and prevents calcium overload caused by the hyperactive I_Na current, thus it stabilizes the membrane and reducing excitability.[12]

Syntex Inc. originally began developing ranolazine in 1985 and 61 studies were completed from then until 1994. Afterwards, Phase 2 studies were done however it was found that the formulation did not result in adequate plasma concentrations of drug. It is due to this that the sustained-release (SR) formulation of ranolazine was created.[13]

Roche acquired Syntex in 1994[13] In 1996, CV Therapeutics licensed the North American and European rights to ranolazine from Syntex, a subsidiary of Roche, which had discovered the drug and had developed it through Phase II trials in angina.[14] In 2006, CV Therapeutics acquired the remaining worldwide rights to ranolazine from Roche.[15] In 2008 CV Therapeutics exclusively licensed rights for ranolazine in Europe and some other countries to Menarini.[16] In 2009, Gilead acquired CV Therapeutics.[17] In 2013 Gilead expanded the partnership with Menarini to include additional countries, including those in Asia.[18]

• "Ranolazine". Drug Information Portal. U.S. National Library of Medicine.