EGIS-12,233
EGIS-12,233 is a drug with applications in scientific research, acting as a potent and selective antagonist for both the 5-HT6 and 5-HT7 serotonin receptor subtypes, with good selectivity over other receptors.[1] It has been shown to increase dopamine release in cochlear tissue, suggesting a role for the 5-HT6 and 5-HT7 receptors in regulation of the hearing system.[2]
![]() | |
Clinical data | |
---|---|
ATC code |
|
Identifiers | |
| |
PubChem CID | |
Chemical and physical data | |
Formula | C24H28Cl3N3O |
Molar mass | 480.86 g·mol−1 |
3D model (JSmol) | |
| |
(verify) |
References
- Volk B, Barkóczy J, Hegedus E, Udvari S, Gacsályi I, Mezei T, et al. (April 2008). "(Phenylpiperazinyl-butyl)oxindoles as selective 5-HT7 receptor antagonists". Journal of Medicinal Chemistry. 51 (8): 2522–32. doi:10.1021/jm070279v. PMID 18361484.
- Doleviczényi Z, Vizi ES, Gacsályi I, Pallagi K, Volk B, Hársing LG, et al. (November 2008). "5-HT6/7 receptor antagonists facilitate dopamine release in the cochlea via a GABAergic disinhibitory mechanism". Neurochemical Research. 33 (11): 2364–72. doi:10.1007/s11064-008-9796-4. PMID 18663573.
Simple piperazines (no additional rings) | |
---|---|
Phenylpiperazines |
|
Benzylpiperazines | |
Diphenylalkylpiperazines (benzhydrylalkylpiperazines) |
|
Pyrimidinylpiperazines | |
Pyridinylpiperazines | |
Benzo(iso)thiazolylpiperazines | |
Tricyclics (piperazine attached via side chain) |
|
Others/Uncategorized |
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.