(tyrosine 3-monooxygenase) kinase
In enzymology, a [tyrosine 3-monooxygenase] kinase (EC 2.7.11.6) is an enzyme that catalyzes the chemical reaction
- ATP + [tyrosine-3-monooxygenase] ADP + phospho-[tyrosine-3-monooxygenase]
| [tyrosine 3-monooxygenase] kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.11.6 | ||||||||
| CAS number | 103537-12-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are ATP and tyrosine 3-monooxygenase, whereas its two products are ADP and phospho-(tyrosine-3-monooxygenase).
This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[tyrosine-3-monoxygenase] phosphotransferase. Other names in common use include pheochromocytoma tyrosine hydroxylase-associated kinase, STK4, and tyrosine 3-monooxygenase kinase (phosphorylating). This enzyme participates in MAPK signaling pathway and non-small cell lung cancer.
References
- Pigeon D, Drissi-Daoudi R, Gros F, Thibault J (1986). "[Copurification of tyrosine hydroxylase from rat pheochromocytoma by protein kinase]". Comptes Rendus de l'Académie des Sciences, Série III. 302 (12): 435–8. PMID 2872947.
- Pigeon D, Ferrara P, Gros F, Thibault J (1987). "Rat pheochromocytoma tyrosine hydroxylase is phosphorylated on serine 40 by an associated protein kinase". J. Biol. Chem. 262 (13): 6155–8. PMID 2883182.