STK10

STK10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2J7T, 4AOT, 4BC6, 4EQU, 4USD, 4USE, 5AJQ
Identifiers
Aliases	STK10, LOK, PRO2729, serine/threonine kinase 10
External IDs	OMIM: 603919 MGI: 1099439 HomoloGene: 38122 GeneCards: STK10
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	172,188,224 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	32,624,587 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• transferase activity; • nucleotide binding; • protein kinase activity; • protein homodimerization activity; • kinase activity; • GO:0001948 protein binding; • identical protein binding; • ATP binding; • protein serine/threonine kinase activity;
Cellular component	• cytoplasm; • membrane; • extracellular exosome; • cell membrane; • specific granule membrane;
Biological process	• lymphocyte aggregation; • phosphorylation; • regulation of lymphocyte migration; • autophosphorylation; • cell cycle; • protein phosphorylation; • neutrophil degranulation; • regulation of mitotic cell cycle; • signal transduction by protein phosphorylation; • stress-activated protein kinase signaling cascade; • activation of protein kinase activity; • regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	6793
	20868
	ENSG00000072786
	ENSMUSG00000020272
	O94804
	O55098
	NM_005990
	NM_009288; NM_001359177; NM_001359178
	NP_005981
	NP_033314; NP_001346106; NP_001346107
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase 10 is an enzyme that in humans is encoded by the STK10 gene.[5][6]

This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.[6]

References

GRCh38: Ensembl release 89: ENSG00000072786 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020272 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kuramochi S, Matsuda Y, Okamoto M, Kitamura F, Yonekawa H, Karasuyama H (Jun 1999). "Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues". Immunogenetics. 49 (5): 369–75. doi:10.1007/s002510050509. PMID 10199912. S2CID 877572.
"Entrez Gene: STK10 serine/threonine kinase 10".

Kuramochi S, Moriguchi T, Kuida K, et al. (1997). "LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes". J. Biol. Chem. 272 (36): 22679–84. doi:10.1074/jbc.272.36.22679. PMID 9278426.
Tao L, Wadsworth S, Mercer J, et al. (2002). "Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells". Biochem. J. 363 (Pt 1): 175–82. doi:10.1042/0264-6021:3630175. PMC 1222464. PMID 11903060.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Walter SA, Cutler RE, Martinez R, et al. (2003). "Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue". J. Biol. Chem. 278 (20): 18221–8. doi:10.1074/jbc.M212556200. PMID 12639966.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Bignell G, Smith R, Hunter C, et al. (2006). "Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults". Genes Chromosomes Cancer. 45 (1): 42–6. doi:10.1002/gcc.20265. PMC 7212027. PMID 16175573.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000072786 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020272 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10199912-5] Kuramochi S, Matsuda Y, Okamoto M, Kitamura F, Yonekawa H, Karasuyama H (Jun 1999). "Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues". Immunogenetics. 49 (5): 369–75. doi:10.1007/s002510050509. PMID 10199912. S2CID 877572.

[entrez-6] "Entrez Gene: STK10 serine/threonine kinase 10".

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

STK10

References

Further reading