TTK (gene)

TTK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2X9E, 2ZMC, 2ZMD, 3CEK, 3DBQ, 3GFW, 3H9F, 3HMN, 3HMO, 3HMP, 3VQU, 3W1F, 3WYX, 3WYY, 3WZJ, 3WZK, 4B94, 4BHZ, 4BI0, 4BI1, 4BI2, 4C4E, 4C4G, 4C4H, 4C4I, 4C4J, 4CV8, 4CV9, 4CVA, 4D2S, 4H7X, 4H7Y, 4JS8, 4JT3, 4O6L, 5AP0, 5AP1, 5AP2, 5AP3, 5AP4, 5AP5, 5AP6, 5AP7, 5EI2, 5EHY, 5EH0, 5EI6, 4ZEG, 5EI8
Identifiers
Aliases	TTK, CT96, ESK, MPH1, MPS1, MPS1L1, PYT, TTK protein kinase
External IDs	OMIM: 604092 MGI: 1194921 HomoloGene: 2489 GeneCards: TTK
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	80,042,527 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	83,872,389 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• kinase activity; • transferase activity; • protein serine/threonine/tyrosine kinase activity; • protein serine/threonine kinase activity; • protein tyrosine kinase activity; • nucleotide binding; • protein kinase activity; • GO:0001948 protein binding; • ATP binding; • protein homodimerization activity; • kinetochore binding;
Cellular component	• spindle; • membrane; • cytoplasm; • kinetochore; • cell nucleus;
Biological process	• chromosome separation; • GO:0043148 mitotic spindle organization; • positive regulation of pathway-restricted SMAD protein phosphorylation; • GO:0043146 spindle organization; • mitotic spindle assembly checkpoint; • positive regulation of cell proliferation; • protein phosphorylation; • phosphorylation; • mitotic cell cycle checkpoint; • peptidyl-tyrosine phosphorylation; • female meiosis chromosome segregation; • peptidyl-serine phosphorylation; • peptidyl-threonine phosphorylation; • meiotic spindle assembly checkpoint; • protein localization to kinetochore; • protein localization to chromosome; • autophosphorylation; • protein localization to meiotic spindle midzone; • chromosome segregation;
	Sources:Amigo / QuickGO
Orthologs
	7272
	22137
	ENSG00000112742
	ENSMUSG00000038379
	P33981
	P35761
	NM_001166691; NM_003318
	NM_001110265; NM_001284272; NM_009445
	NP_001160163; NP_003309
	NP_001103735; NP_001271201; NP_033471
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity protein kinase TTK also known as Mps1 is an enzyme that in humans is encoded by the TTK gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000112742 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000038379 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Mills GB, Schmandt R, McGill M, Amendola A, Hill M, Jacobs K, May C, Rodricks AM, Campbell S, Hogg D (Aug 1992). "Expression of TTK, a novel human protein kinase, is associated with cell proliferation". J Biol Chem. 267 (22): 16000–6. PMID 1639825.
"Entrez Gene: TTK TTK protein kinase".

Hanks SK, Quinn AM (1991). "Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members". Meth. Enzymol. Methods in Enzymology. 200: 38–62. doi:10.1016/0076-6879(91)00126-H. ISBN 978-0-12-182101-2. PMID 1956325.
Lindberg RA, Fischer WH, Hunter T (1993). "Characterization of a human protein threonine kinase isolated by screening an expression library with antibodies to phosphotyrosine". Oncogene. 8 (2): 351–9. PMID 7678926.
Lauzé E, Stoelcker B, Luca FC, et al. (1995). "Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase". EMBO J. 14 (8): 1655–63. doi:10.1002/j.1460-2075.1995.tb07154.x. PMC 398258. PMID 7737118.
Cahill DP, da Costa LT, Carson-Walter EB, et al. (1999). "Characterization of MAD2B and other mitotic spindle checkpoint genes". Genomics. 58 (2): 181–7. doi:10.1006/geno.1999.5831. PMID 10366450.
Weinmann AS, Yan PS, Oberley MJ, et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis". Genes Dev. 16 (2): 235–44. doi:10.1101/gad.943102. PMC 155318. PMID 11799066.
Stucke VM, Silljé HH, Arnaud L, Nigg EA (2002). "Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication". EMBO J. 21 (7): 1723–32. doi:10.1093/emboj/21.7.1723. PMC 125937. PMID 11927556.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Liu ST, Chan GK, Hittle JC, et al. (2003). "Human MPS1 Kinase Is Required for Mitotic Arrest Induced by the Loss of CENP-E from Kinetochores". Mol. Biol. Cell. 14 (4): 1638–51. doi:10.1091/mbc.02-05-0074. PMC 153128. PMID 12686615.
Fisk HA, Mattison CP, Winey M (2004). "Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression". Proc. Natl. Acad. Sci. U.S.A. 100 (25): 14875–80. doi:10.1073/pnas.2434156100. PMC 299837. PMID 14657364.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dou Z, Ding X, Zereshki A, et al. (2004). "TTK kinase is essential for the centrosomal localization of TACC2". FEBS Lett. 572 (1–3): 51–6. doi:10.1016/j.febslet.2004.06.092. PMID 15304323. S2CID 8403635.
Wei JH, Chou YF, Ou YH, et al. (2005). "TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68". J. Biol. Chem. 280 (9): 7748–57. doi:10.1074/jbc.M410152200. PMID 15618221.
Camacho E, Beà S, Salaverría I, et al. (2006). "Analysis of Aurora-A and hMPS1 mitotic kinases in mantle cell lymphoma". Int. J. Cancer. 118 (2): 357–63. doi:10.1002/ijc.21370. PMID 16080195. S2CID 7968793.
Leng M, Chan DW, Luo H, et al. (2006). "MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability". Proc. Natl. Acad. Sci. U.S.A. 103 (31): 11485–90. Bibcode:2006PNAS..10311485L. doi:10.1073/pnas.0601828103. PMC 1518802. PMID 16864798.
Bertheau P, Turpin E, Rickman DS, et al. (2007). "Exquisite Sensitivity of TP53 Mutant and Basal Breast Cancers to a Dose-Dense Epirubicin−Cyclophosphamide Regimen". PLOS Med. 4 (3): e90. doi:10.1371/journal.pmed.0040090. PMC 1831731. PMID 17388661.
Zhu S, Wang W, Clarke DC, Liu X (2007). "Activation of Mps1 promotes transforming growth factor-beta-independent Smad signaling". J. Biol. Chem. 282 (25): 18327–38. doi:10.1074/jbc.M700636200. PMID 17452325.
Kanai M, Ma Z, Izumi H, et al. (2007). "Physical and functional interaction between mortalin and Mps1 kinase". Genes Cells. 12 (6): 797–810. doi:10.1111/j.1365-2443.2007.01091.x. PMID 17573779. S2CID 342866.
Mattison CP, Old WM, Steiner E, et al. (2007). "Mps1 activation loop autophosphorylation enhances kinase activity". J. Biol. Chem. 282 (42): 30553–61. doi:10.1074/jbc.M707063200. PMID 17728254.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112742 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038379 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1639825-5] Mills GB, Schmandt R, McGill M, Amendola A, Hill M, Jacobs K, May C, Rodricks AM, Campbell S, Hogg D (Aug 1992). "Expression of TTK, a novel human protein kinase, is associated with cell proliferation". J Biol Chem. 267 (22): 16000–6. PMID 1639825.

[entrez-6] "Entrez Gene: TTK TTK protein kinase".

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

TTK (gene)

References

Further reading