CAMK2D

Calcium/calmodulin-dependent protein kinase type II delta chain is an enzyme that in humans is encoded by the CAMK2D gene.[5]

CAMK2D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VN9, 2W2C, 2WEL, 3GP2
Identifiers
Aliases	CAMK2D, CAMKD, calcium/calmodulin dependent protein kinase II delta
External IDs	OMIM: 607708 MGI: 1341265 HomoloGene: 55561 GeneCards: CAMK2D
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q26 Start 113,451,032 bp[1] End 113,761,927 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G1 Start 126,596,302 bp[2] End 126,846,326 bp[2]
Gene ontology Molecular function • kinase activity • ATP binding • protein kinase activity • titin binding • transferase activity • protein homodimerization activity • GO:0001948 protein binding • nucleotide binding • sodium channel inhibitor activity • calmodulin-dependent protein kinase activity • Ras guanyl-nucleotide exchange factor activity • protein serine/threonine kinase activity • ion channel binding • calmodulin binding • identical protein binding Cellular component • endocytic vesicle membrane • membrane • sarcoplasmic reticulum membrane • cell membrane • nucleoplasm • sarcoplasmic reticulum • sarcolemma • neuron projection • cell nucleus • cytoplasm • cytosol • calcium channel complex Biological process • regulation of heart contraction • interferon-gamma-mediated signaling pathway • regulation of transcription from RNA polymerase II promoter • regulation of membrane depolarization • positive regulation of cardiac muscle hypertrophy • protein phosphorylation • cellular response to calcium ion • regulation of cardiac muscle cell action potential involved in regulation of contraction • regulation of histone deacetylase activity • regulation of cellular localization • negative regulation of sodium ion transmembrane transport • phosphorylation • regulation of the force of heart contraction • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion • regulation of ryanodine-sensitive calcium-release channel activity • negative regulation of sodium ion transmembrane transporter activity • MAPK cascade • protein oligomerization • regulation of cell growth • regulation of cellular response to heat • regulation of cell communication by electrical coupling involved in cardiac conduction • regulation of heart rate by cardiac conduction • nervous system development • cell differentiation • regulation of cell communication by electrical coupling • positive regulation of cardiac muscle cell apoptotic process • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • endoplasmic reticulum calcium ion homeostasis • autophosphorylation • relaxation of cardiac muscle • cardiac muscle cell contraction • regulation of cardiac muscle cell action potential • regulation of relaxation of cardiac muscle • regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	817	108058
Ensembl	ENSG00000145349	ENSMUSG00000053819
UniProt	Q13557	Q6PHZ2
RefSeq (mRNA)	NM_001221 NM_172114 NM_172115 NM_172127 NM_172128 NM_172129 NM_001321566 NM_001321567 NM_001321568 NM_001321569 NM_001321570 NM_001321571 NM_001321572 NM_001321573 NM_001321574 NM_001321575 NM_001321576 NM_001321577 NM_001321578 NM_001321579 NM_001321580 NM_001321581 NM_001321582 NM_001321583 NM_001321584 NM_001321585 NM_001321586 NM_001321587 NM_001321588 NM_001321589 NM_001321590 NM_001321591 NM_001321592	NM_001025438 NM_001025439 NM_001293663 NM_001293664 NM_001293665 NM_001293666 NM_023813 NM_001346635 NM_001346636
RefSeq (protein)	NP_001212 NP_001308495 NP_001308496 NP_001308497 NP_001308498 NP_001308499 NP_001308500 NP_001308501 NP_001308502 NP_001308503 NP_001308504 NP_001308505 NP_001308506 NP_001308507 NP_001308508 NP_001308509 NP_001308510 NP_001308511 NP_001308512 NP_001308513 NP_001308514 NP_001308515 NP_001308516 NP_001308517 NP_001308518 NP_001308519 NP_001308520 NP_001308521 NP_742112 NP_742113 NP_742125 NP_742126 NP_742127	NP_001020609 NP_001020610 NP_001280592 NP_001280593 NP_001280594 NP_001280595 NP_001333564 NP_001333565 NP_076302
Location (UCSC)	Chr 4: 113.45 – 113.76 Mb	Chr 3: 126.6 – 126.85 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca²⁺/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Four alternatively spliced transcript variants that encode three different isoforms have been characterized to date. Distinct isoforms of this chain have different expression patterns.[5]