Protein kinase, AMP-activated, alpha 1

5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene.[5][6]

PRKAA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4RED, 4RER, 4REW, 5EZV
Identifiers
Aliases	PRKAA1, AMPK, AMPKa1, Protein kinase, AMP-activated, alpha 1, protein kinase AMP-activated catalytic subunit alpha 1
External IDs	OMIM: 602739 MGI: 2145955 HomoloGene: 49590 GeneCards: PRKAA1
EC number	2.7.11.26
Gene location (Human) Chr. Chromosome 5 (human)[1] Band n/a Start 40,759,379 bp[1] End 40,798,374 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 A1 Start 5,143,861 bp[2] End 5,181,899 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • cAMP-dependent protein kinase activity • [acetyl-CoA carboxylase kinase activity] • AMP-activated protein kinase activity • histone serine kinase activity • chromatin binding • metal ion binding • kinase activity • protein serine/threonine kinase activity • tau-protein kinase activity • protein C-terminus binding • GO:0001948 protein binding • [hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity] • ATP binding • tau protein binding Cellular component • nucleotide-activated protein kinase complex • apical plasma membrane • nucleoplasm • cell nucleus • cytoplasm • cytosol • nuclear speck • intracellular • axon • dendrite • macromolecular complex • neuronal cell body Biological process • cellular response to organonitrogen compound • steroid metabolic process • cellular response to glucose starvation • sterol biosynthetic process • lipid biosynthetic process • regulation of transcription, DNA-templated • response to hypoxia • cellular response to ethanol • glucose homeostasis • positive regulation of skeletal muscle tissue development • protein heterooligomerization • rhythmic process • phosphorylation • lipid metabolism • regulation of vesicle-mediated transport • negative regulation of apoptotic process • cholesterol metabolic process • Wnt signaling pathway • response to activity • fatty acid metabolic process • transcription, DNA-templated • cellular response to prostaglandin E stimulus • autophagy • protein phosphorylation • negative regulation of TOR signaling • cold acclimation • positive regulation of gene expression • response to camptothecin • fatty acid biosynthetic process • fatty acid homeostasis • regulation of circadian rhythm • activation of MAPK activity • fatty acid oxidation • regulation of peptidyl-serine phosphorylation • cellular response to nutrient levels • positive regulation of cell proliferation • negative regulation of glucosylceramide biosynthetic process • glucose metabolic process • cell cycle arrest • positive regulation of cholesterol biosynthetic process • response to caffeine • histone-serine phosphorylation • cholesterol biosynthetic process • negative regulation of lipid catabolic process • response to gamma radiation • macroautophagy • response to UV • positive regulation of glycolytic process • response to hydrogen peroxide • cellular response to hypoxia • signal transduction • cellular response to hydrogen peroxide • steroid biosynthetic process • regulation of signal transduction by p53 class mediator • positive regulation of autophagy • CAMKK-AMPK signaling cascade • regulation of macroautophagy • chromatin organization • positive regulation of transcription from mitochondrial promoter • positive regulation of protein targeting to mitochondrion • negative regulation of gene expression • cellular response to oxidative stress • GO:0007243 intracellular signal transduction • negative regulation of insulin receptor signaling pathway • motor behavior • regulation of stress granule assembly • neuron cellular homeostasis • regulation of microtubule cytoskeleton organization • cellular response to calcium ion • cellular response to glucose stimulus • energy homeostasis • positive regulation of cellular protein localization • negative regulation of tubulin deacetylation • positive regulation of peptidyl-lysine acetylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5562	105787
Ensembl	ENSG00000132356	ENSMUSG00000050697
UniProt	Q13131	Q5EG47
RefSeq (mRNA)	NM_006251 NM_206907	NM_001013367 NM_001355640
RefSeq (protein)	NP_006242 NP_996790 NP_001341957 NP_001341958 NP_001341963 NP_001341964 NP_001341965 NP_001341966	NP_001013385 NP_001342569
Location (UCSC)	Chr 5: 40.76 – 40.8 Mb	Chr 15: 5.14 – 5.18 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the serine/threonine protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[6]