CAMK4

Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene.[5]

CAMK4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCAMK4, CaMK IV, CaMK-GR, IV, caMK, calcium/calmodulin-dependent protein kinase IV, calcium/calmodulin dependent protein kinase IV, CaMKIV
External IDsOMIM: 114080 MGI: 88258 HomoloGene: 100780 GeneCards: CAMK4
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q22.1Start111,223,653 bp[1]
End111,494,886 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

814

12326

Ensembl

ENSG00000152495

ENSMUSG00000038128

UniProt

Q16566

P08414
Q8BGR3

RefSeq (mRNA)

NM_001744
NM_001323374
NM_001323375
NM_001323376
NM_001323377

NM_009793

RefSeq (protein)

NP_001310303
NP_001310304
NP_001310305
NP_001310306
NP_001735

NP_033923

Location (UCSC)Chr 5: 111.22 – 111.49 MbChr 18: 32.93 – 33.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca2+/calmodulin-dependent protein kinase (CAMK) subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons, and male germ cells.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000152495 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000038128 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Sikela JM, Law ML, Kao FT, Hartz JA, Wei Q, Hahn WE (Mar 1989). "Chromosomal localization of the human gene for brain Ca2+/calmodulin-dependent protein kinase type IV". Genomics. 4 (1): 21–7. doi:10.1016/0888-7543(89)90309-1. PMID 2536634.
  6. "Entrez Gene: CAMK4 calcium/calmodulin-dependent protein kinase IV".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.