MAP3K4

Mitogen-activated protein kinase kinase kinase 4 is an enzyme that in humans is encoded by the MAP3K4 gene.[5][6]

MAP3K4
Identifiers
AliasesMAP3K4, MAPKKK4, MEKK 4, MEKK4, MTK1, PRO0412, mitogen-activated protein kinase kinase kinase 4
External IDsOMIM: 602425 MGI: 1346875 HomoloGene: 31346 GeneCards: MAP3K4
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q26Start160,991,727 bp[1]
End161,117,385 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4216

26407

Ensembl

ENSG00000085511

ENSMUSG00000014426

UniProt

Q9Y6R4

O08648

RefSeq (mRNA)

NM_001291958
NM_001301072
NM_005922
NM_006724
NM_001363582

NM_011948
NM_001357722

RefSeq (protein)

NP_001278887
NP_001288001
NP_005913
NP_006715
NP_001350511

NP_036078
NP_001344651

Location (UCSC)Chr 6: 160.99 – 161.12 MbChr 17: 12.23 – 12.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 (p38α) and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 (p38α) and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 (MKK6) and SERK1 (MKK4), MAPKKs that activate CSBP2 (p38α) and JNK, respectively but cannot phosphorylate PRKMK1 (MKK1), an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the p38 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described.[6]

Interactions

MAP3K4 has been shown to interact with GADD45G,[7] GADD45B[7] and GADD45A.[7]

References

Further reading

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