Fas-activated serine/threonine kinase
In enzymology, a Fas-activated serine/threonine kinase (EC 2.7.11.8) is an enzyme that catalyzes the chemical reaction
- ATP + [Fas-activated serine/threonine protein] ADP + [Fas-activated serine/threonine phosphoprotein]
| Fas-activated serine/threonine kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.11.8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are ATP and Fas-activated serine/threonine protein, whereas its two products are ADP and Fas-activated serine/threonine phosphoprotein.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups protein-serine/threonine kinases. The systematic name of this enzyme class is ATP:[Fas-activated serine/threonine protein] phosphotransferase. Other names in common use include FAST, FASTK, and STK10.
References
- Tian Q, Taupin J, Elledge S, Robertson M, Anderson P (1995). "Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis". J. Exp. Med. 182 (3): 865–74. doi:10.1084/jem.182.3.865. PMC 2192163. PMID 7544399.
- Li W, Simarro M, Kedersha N, Anderson P (2004). "FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression". Mol. Cell. Biol. 24 (24): 10718–32. doi:10.1128/MCB.24.24.10718-10732.2004. PMC 533970. PMID 15572676.
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