DAPK3

Death-associated protein kinase 3 is an enzyme that in humans is encoded by the DAPK3 gene.[5][6]

DAPK3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDAPK3, DLK, ZIP, ZIPK, death-associated protein kinase 3, death associated protein kinase 3
External IDsOMIM: 603289 MGI: 1203520 HomoloGene: 20353 GeneCards: DAPK3
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p13.3Start3,958,453 bp[1]
End3,971,123 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1613

13144

Ensembl

ENSG00000167657

ENSMUSG00000034974

UniProt

O43293

O54784

RefSeq (mRNA)

NM_001348
NM_001375658

NM_001190473
NM_001190474
NM_007828

RefSeq (protein)

NP_001339
NP_001362587

NP_001177402
NP_001177403
NP_031854

Location (UCSC)Chr 19: 3.96 – 3.97 MbChr 10: 81.18 – 81.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.[6]

Unlike most other mammalian genes, murine (rat and mouse) DAPK3 has undergone accelerated evolution and diverged from the tightly conserved consensus that is maintained from fish to human.[7]

Interactions

DAPK3 has been shown to interact with PAWR[8] and Death associated protein 6.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000167657 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000034974 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S (Mar 1998). "ZIP kinase, a novel serine/threonine kinase which mediates apoptosis". Molecular and Cellular Biology. 18 (3): 1642–51. doi:10.1128/mcb.18.3.1642. PMC 108879. PMID 9488481.
  6. "Entrez Gene: DAPK3 death-associated protein kinase 3".
  7. Shoval Y, Pietrokovski S, Kimchi A (Oct 2007). "ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene". PLOS Genetics. 3 (10): 1884–93. doi:10.1371/journal.pgen.0030180. PMC 2041995. PMID 17953487.
  8. Kawai T, Akira S, Reed JC (Sep 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Molecular and Cellular Biology. 23 (17): 6174–86. doi:10.1128/MCB.23.17.6174-6186.2003. PMC 180930. PMID 12917339.

Further reading


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