DAPK3

DAPK3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YRP, 2J90, 3BHY, 3BQR, 5A6O, 5A6N
Identifiers
Aliases	DAPK3, DLK, ZIP, ZIPK, death-associated protein kinase 3, death associated protein kinase 3
External IDs	OMIM: 603289 MGI: 1203520 HomoloGene: 20353 GeneCards: DAPK3
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	3,971,123 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	81,193,197 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• transferase activity; • nucleotide binding; • protein kinase activity; • protein homodimerization activity; • cAMP response element binding protein binding; • kinase activity; • protein serine/threonine kinase activity; • leucine zipper domain binding; • GO:0001948 protein binding; • identical protein binding; • Rho GTPase binding; • ATP binding; • protein C-terminus binding;
Cellular component	• PML body; • actin filament; • membrane raft; • cell nucleus; • cytoplasm;
Biological process	• regulation of apoptotic process; • regulation of actin cytoskeleton reorganization; • negative regulation of translation; • GO:0007243 intracellular signal transduction; • regulation of transcription, DNA-templated; • regulation of smooth muscle contraction; • phosphorylation; • positive regulation of cell migration; • positive regulation of canonical Wnt signaling pathway; • regulation of myosin II filament organization; • transcription, DNA-templated; • regulation of cell motility; • protein phosphorylation; • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; • regulation of autophagy; • neuron differentiation; • regulation of mitotic cell cycle; • regulation of cell shape; • positive regulation of apoptotic process; • regulation of focal adhesion assembly; • cellular response to interferon-gamma; • apoptotic signaling pathway; • autophosphorylation; • regulation of translation; • regulation of mitotic nuclear division; • apoptotic process; • peptidyl-serine phosphorylation; • peptidyl-threonine phosphorylation; • chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	1613
	13144
	ENSG00000167657
	ENSMUSG00000034974
	O43293
	O54784
	NM_001348; NM_001375658
	NM_001190473; NM_001190474; NM_007828
	NP_001339; NP_001362587
	NP_001177402; NP_001177403; NP_031854
	Wikidata
View/Edit Human	View/Edit Mouse

Death-associated protein kinase 3 is an enzyme that in humans is encoded by the DAPK3 gene.[5][6]

Function

Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.[6]

Unlike most other mammalian genes, murine (rat and mouse) DAPK3 has undergone accelerated evolution and diverged from the tightly conserved consensus that is maintained from fish to human.[7]

Interactions

DAPK3 has been shown to interact with PAWR[8] and Death associated protein 6.[8]

References

GRCh38: Ensembl release 89: ENSG00000167657 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000034974 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S (Mar 1998). "ZIP kinase, a novel serine/threonine kinase which mediates apoptosis". Molecular and Cellular Biology. 18 (3): 1642–51. doi:10.1128/mcb.18.3.1642. PMC 108879. PMID 9488481.
"Entrez Gene: DAPK3 death-associated protein kinase 3".
Shoval Y, Pietrokovski S, Kimchi A (Oct 2007). "ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene". PLOS Genetics. 3 (10): 1884–93. doi:10.1371/journal.pgen.0030180. PMC 2041995. PMID 17953487.
Kawai T, Akira S, Reed JC (Sep 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Molecular and Cellular Biology. 23 (17): 6174–86. doi:10.1128/MCB.23.17.6174-6186.2003. PMC 180930. PMID 12917339.

Saito T, Seki N, Ohira M, Hayashi A, Kozuma S, Hattori A, Hori T (1998). "Assignment of the ZIP kinase gene to human chromosome 19p13.3 by somatic hybrid analysis and fluorescence in-situ hybridization". Journal of Human Genetics. 43 (3): 209–11. doi:10.1007/s100380050073. PMID 9747039.
Murata-Hori M, Suizu F, Iwasaki T, Kikuchi A, Hosoya H (May 1999). "ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells". FEBS Letters. 451 (1): 81–4. doi:10.1016/S0014-5793(99)00550-5. PMID 10356987. S2CID 43329315.
Page G, Lödige I, Kögel D, Scheidtmann KH (Nov 1999). "AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis". FEBS Letters. 462 (1–2): 187–91. doi:10.1016/S0014-5793(99)01529-X. PMID 10580117. S2CID 6061613.
Page G, Kögel D, Rangnekar V, Scheidtmann KH (Dec 1999). "Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis". Oncogene. 18 (51): 7265–73. doi:10.1038/sj.onc.1203170. PMID 10602480.
Cariou B, Perdereau D, Cailliau K, Browaeys-Poly E, Béréziat V, Vasseur-Cognet M, Girard J, Burnol AF (Oct 2002). "The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta". Molecular and Cellular Biology. 22 (20): 6959–70. doi:10.1128/MCB.22.20.6959-6970.2002. PMC 139806. PMID 12242277.
Preuss U, Landsberg G, Scheidtmann KH (Feb 2003). "Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase". Nucleic Acids Research. 31 (3): 878–85. doi:10.1093/nar/gkg176. PMC 149197. PMID 12560483.
Kawai T, Akira S, Reed JC (Sep 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Molecular and Cellular Biology. 23 (17): 6174–86. doi:10.1128/MCB.23.17.6174-6186.2003. PMC 180930. PMID 12917339.
Burch LR, Scott M, Pohler E, Meek D, Hupp T (Mar 2004). "Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1". Journal of Molecular Biology. 337 (1): 115–28. doi:10.1016/j.jmb.2003.10.081. PMID 15001356.
Endo A, Surks HK, Mochizuki S, Mochizuki N, Mendelsohn ME (Oct 2004). "Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase". The Journal of Biological Chemistry. 279 (40): 42055–61. doi:10.1074/jbc.M403676200. PMID 15292222.
Schaaf CP, Benzing J, Schmitt T, Erz DH, Tewes M, Bartram CR, Janssen JW (Feb 2005). "Novel interaction partners of the TPR/MET tyrosine kinase". FASEB Journal. 19 (2): 267–9. doi:10.1096/fj.04-1558fje. PMID 15546961. S2CID 17142907.
Yu H, Jiang D, Guo Z, Saiyin H, Guo J, Wang X, Yu L (Jun 2005). "TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3". International Journal of Andrology. 28 (3): 163–70. doi:10.1111/j.1365-2605.2005.00522.x. PMID 15910542.
Shoval Y, Pietrokovski S, Kimchi A (Oct 2007). "ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene". PLOS Genetics. 3 (10): 1884–93. doi:10.1371/journal.pgen.0030180. PMC 2041995. PMID 17953487.
Takamoto N, Komatsu S, Komaba S, Niiro N, Ikebe M (Dec 2006). "Novel ZIP kinase isoform lacks leucine zipper". Archives of Biochemistry and Biophysics. 456 (2): 194–203. doi:10.1016/j.abb.2006.09.026. PMC 2758612. PMID 17126281.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167657 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034974 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9488481-5] Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S (Mar 1998). "ZIP kinase, a novel serine/threonine kinase which mediates apoptosis". Molecular and Cellular Biology. 18 (3): 1642–51. doi:10.1128/mcb.18.3.1642. PMC 108879. PMID 9488481.

[entrez-6] "Entrez Gene: DAPK3 death-associated protein kinase 3".

[pmid17953487-7] Shoval Y, Pietrokovski S, Kimchi A (Oct 2007). "ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene". PLOS Genetics. 3 (10): 1884–93. doi:10.1371/journal.pgen.0030180. PMC 2041995. PMID 17953487.

[pmid12917339-8] Kawai T, Akira S, Reed JC (Sep 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Molecular and Cellular Biology. 23 (17): 6174–86. doi:10.1128/MCB.23.17.6174-6186.2003. PMC 180930. PMID 12917339.

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

DAPK3

Function

Interactions

References

Further reading