BRSK2

BRSK2
Identifiers
Aliases	BRSK2, C11orf7, PEN11B, SAD1, SADA, STK29, BR serine/threonine kinase 2
External IDs	OMIM: 609236 MGI: 1923020 HomoloGene: 123829 GeneCards: BRSK2
EC number	2.7.11.26
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	1,462,689 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	142,004,247 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• transferase activity; • nucleotide binding; • protein kinase activity; • ATPase binding; • ATPase regulator activity; • metal ion binding; • kinase activity; • protein kinase binding; • magnesium ion binding; • tau-protein kinase activity; • protein serine/threonine kinase activity; • ATP binding; • tau protein binding;
Cellular component	• centrosome; • microtubule organizing center; • perinuclear region of cytoplasm; • cytoskeleton; • cell nucleus; • cytoplasm; • endoplasmic reticulum; • distal axon;
Biological process	• actin cytoskeleton reorganization; • neuron projection morphogenesis; • ERAD pathway; • phosphorylation; • nervous system development; • cell division; • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; • G2/M transition of mitotic cell cycle; • peptidyl-serine phosphorylation; • cell cycle; • regulation of ATPase activity; • regulation of retrograde protein transport, ER to cytosol; • exocytosis; • apoptotic process; • establishment of cell polarity; • regulation of insulin secretion involved in cellular response to glucose stimulus; • axonogenesis; • protein phosphorylation; • neuron differentiation; • regulation of neuron projection development; • GO:0007243 intracellular signal transduction; • regulation of axonogenesis; • microtubule cytoskeleton organization involved in establishment of planar polarity; • regulation of synaptic vesicle clustering;
	Sources:Amigo / QuickGO
Orthologs
	9024
	75770
	ENSG00000174672
	ENSMUSG00000053046
	Q8IWQ3
	Q69Z98
	NM_001256627; NM_001256629; NM_001256630; NM_001282218; NM_003957
	NM_001009929; NM_001009930; NM_001276763; NM_029426
	NP_001243556; NP_001243558; NP_001243559; NP_001269147; NP_003948
	NP_001009929; NP_001009930; NP_001263692; NP_083702
	Wikidata
View/Edit Human	View/Edit Mouse

BR serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the BRSK2 gene.[5][6][7]

References

GRCh38: Ensembl release 89: ENSG00000174672 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000053046 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Miura K, Masuzaki H, Ishimaru T, Niikawa N, Jinno Y (Jan 1999). "A HhaI/BstUI polymorphism in a novel gene at human chromosome 11p15.5". Journal of Human Genetics. 43 (4): 283–4. doi:10.1007/s100380050092. PMID 9852686.
Miura K, Miyoshi O, Yun K, Inazawa J, Miyamoto T, Hayashi H, Masuzaki H, Yoshimura S, Niikawa N, Jinno Y, Ishimaru T (Mar 1999). "Repeat-directed isolation of a novel gene preferentially expressed from the maternal allele in human placenta". Journal of Human Genetics. 44 (1): 1–9. doi:10.1007/s100380050096. PMID 9929968.
"Entrez Gene: BRSK2 BR serine/threonine kinase 2".

External links

Human BRSK2 genome location and BRSK2 gene details page in the UCSC Genome Browser.

Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G (Jan 2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast. 18 (1): 69–80. doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H. PMID 11124703.
Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR (Feb 2004). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". The EMBO Journal. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552.
Lu R, Niida H, Nakanishi M (Jul 2004). "Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function". The Journal of Biological Chemistry. 279 (30): 31164–70. doi:10.1074/jbc.M404728200. PMID 15150265.
Sabater L, Gómez-Choco M, Saiz A, Graus F (Dec 2005). "BR serine/threonine kinase 2: a new autoantigen in paraneoplastic limbic encephalitis". Journal of Neuroimmunology. 170 (1–2): 186–90. doi:10.1016/j.jneuroim.2005.08.011. PMID 16165222. S2CID 2531035.
Inoue E, Mochida S, Takagi H, Higa S, Deguchi-Tawarada M, Takao-Rikitsu E, Inoue M, Yao I, Takeuchi K, Kitajima I, Setou M, Ohtsuka T, Takai Y (Apr 2006). "SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release". Neuron. 50 (2): 261–75. doi:10.1016/j.neuron.2006.03.018. PMID 16630837. S2CID 15232412.
Guo Z, Tang W, Yuan J, Chen X, Wan B, Gu X, Luo K, Wang Y, Yu L (Sep 2006). "BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260". Biochemical and Biophysical Research Communications. 347 (4): 867–71. doi:10.1016/j.bbrc.2006.06.178. PMID 16870137.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174672 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053046 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9852686-5] Miura K, Masuzaki H, Ishimaru T, Niikawa N, Jinno Y (Jan 1999). "A HhaI/BstUI polymorphism in a novel gene at human chromosome 11p15.5". Journal of Human Genetics. 43 (4): 283–4. doi:10.1007/s100380050092. PMID 9852686.

[pmid9929968-6] Miura K, Miyoshi O, Yun K, Inazawa J, Miyamoto T, Hayashi H, Masuzaki H, Yoshimura S, Niikawa N, Jinno Y, Ishimaru T (Mar 1999). "Repeat-directed isolation of a novel gene preferentially expressed from the maternal allele in human placenta". Journal of Human Genetics. 44 (1): 1–9. doi:10.1007/s100380050096. PMID 9929968.

[entrez-7] "Entrez Gene: BRSK2 BR serine/threonine kinase 2".

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

BRSK2

References

External links

Further reading