SNRK

SNRK
Identifiers
Aliases	SNRK, HSNFRK, SNF related kinase
External IDs	OMIM: 612760 MGI: 108104 HomoloGene: 9797 GeneCards: SNRK
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	43,424,764 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	122,169,702 bp[2]
Gene ontology
Molecular function	• transferase activity; • nucleotide binding; • protein kinase activity; • protein serine/threonine kinase activity; • ATP binding; • magnesium ion binding; • metal ion binding; • kinase activity;
Cellular component	• cytoplasm; • cell nucleus;
Biological process	• protein phosphorylation; • myeloid cell differentiation; • GO:0007243 intracellular signal transduction; • phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	54861
	20623
	ENSG00000163788
	ENSMUSG00000038145
	Q9NRH2
	Q8VDU5
	NM_001100594; NM_017719; NM_001330750
	NM_001164572; NM_133741; NM_001357774; NM_001357775; NM_001357776
	NP_001094064; NP_001317679; NP_060189
	NP_001158044; NP_598502; NP_001344703; NP_001344704; NP_001344705
	Wikidata
View/Edit Human	View/Edit Mouse

SNF-related serine/threonine-protein kinase is an enzyme that in humans is encoded by the SNRK gene.[5][6][7]

References

GRCh38: Ensembl release 89: ENSG00000163788 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000038145 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Becker W, Heukelbach J, Kentrup H, Joost HG (Jul 1996). "Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a subfamily of serine/threonine kinases". Eur J Biochem. 235 (3): 736–43. doi:10.1111/j.1432-1033.1996.00736.x. PMID 8654423.
Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
"Entrez Gene: SNRK SNF related kinase".

8. Thirugnanam K, Cossette SM, Lu Q, Chowdhury SR, Harmann LM, Gupta A, Spearman AD, Sonin DL, Bordas M, Kumar SN, Pan AY, Simpson PM, Strande JL, Bishop E, Zou MH, Ramchandran R. Cardiomyocyte-Specific Snrk Prevents Inflammation in the Heart. J Am Heart Assoc. 2019 Nov 19;8(22):e012792. doi: 10.1161/JAHA.119.012792. Epub 2019 Nov 13. PMID: 31718444; PMCID: PMC6915262.

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Iacobelli M, Wachsman W, McGuire KL (2000). "Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein". J. Immunol. 165 (2): 860–8. doi:10.4049/jimmunol.165.2.860. PMID 10878360.
Yoshida K, Yamada M, Nishio C, Konishi A, Hatanaka H (2000). "SNRK, a member of the SNF1 family, is related to low K(+)-induced apoptosis of cultured rat cerebellar granule neurons". Brain Res. 873 (2): 274–82. doi:10.1016/S0006-8993(00)02548-8. PMID 10930554. S2CID 26034531.
Bower KE, Zeller RW, Wachsman W, Martinez T, McGuire KL (2002). "Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions". J. Biol. Chem. 277 (38): 34967–77. doi:10.1074/jbc.M205048200. PMID 12087103.
Kertesz N, Samson J, Debacker C, Wu H, Labastie MC (2003). "Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases". Gene. 294 (1–2): 13–24. doi:10.1016/S0378-1119(02)00829-6. PMID 12234663.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Jaleel M, McBride A, Lizcano JM, Deak M, Toth R, Morrice NA, Alessi DR (2005). "Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate". FEBS Lett. 579 (6): 1417–23. doi:10.1016/j.febslet.2005.01.042. PMID 15733851. S2CID 30479196.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163788 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038145 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8654423-5] Becker W, Heukelbach J, Kentrup H, Joost HG (Jul 1996). "Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a subfamily of serine/threonine kinases". Eur J Biochem. 235 (3): 736–43. doi:10.1111/j.1432-1033.1996.00736.x. PMID 8654423.

[pmid7788527-6] Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.

[entrez-7] "Entrez Gene: SNRK SNF related kinase".

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

SNRK

References

Further reading