PLK2

PLK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4I5M, 4I5P, 4I6B, 4I6F, 4I6H, 4RS6, 4XB0
Identifiers
Aliases	PLK2, SNK, hPlk2, hSNK, polo like kinase 2
External IDs	OMIM: 607023 MGI: 1099790 HomoloGene: 21317 GeneCards: PLK2
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	58,460,139 bp[1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[2]
End	110,400,844 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• transferase activity; • nucleotide binding; • protein kinase activity; • GO:0032403 macromolecular complex binding; • signal transducer activity; • ATP-dependent protein binding; • kinase activity; • GO:0001948 protein binding; • ATP binding; • protein serine/threonine kinase activity;
Cellular component	• cytoplasm; • centrosome; • cell projection; • intracellular; • dendrite; • centriole; • chromatin; • cytoskeleton; • cytosol;
Biological process	• positive regulation of protein catabolic process; • positive regulation of autophagy; • phosphorylation; • mitotic cell cycle checkpoint; • G1 phase; • GO:0043148 mitotic spindle organization; • Rap protein signal transduction; • regulation of centriole replication; • negative regulation of apoptotic process; • memory; • regulation of synaptic plasticity; • protein phosphorylation; • peptidyl-serine phosphorylation; • long term synaptic depression; • GO:0007067 mitotic cell cycle; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • Ras protein signal transduction; • positive regulation of protein binding; • negative regulation of dendritic spine development; • positive regulation of proteasomal ubiquitin-dependent protein catabolic process; • long-term synaptic potentiation; • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;
	Sources:Amigo / QuickGO
Orthologs
	10769
	20620
	ENSG00000145632
	ENSMUSG00000021701
	Q9NYY3
	P53351
	NM_006622; NM_001252226
	NM_152804
	NP_001239155; NP_006613
	NP_690017
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase PLK2 is an enzyme that in humans is encoded by the PLK2 gene.[5]

Serum-inducible kinase is a member of the 'polo' family of serine/threonine protein kinases that have a role in normal cell division. [supplied by OMIM][5]

References

GRCh38: Ensembl release 89: ENSG00000145632 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021701 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: PLK2 polo-like kinase 2 (Drosophila)".

Kauselmann G, Weiler M, Wulff P, et al. (1999). "The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity". EMBO J. 18 (20): 5528–39. doi:10.1093/emboj/18.20.5528. PMC 1171621. PMID 10523297.
Ouyang B, Li W, Pan H, et al. (1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene. 18 (44): 6029–36. doi:10.1038/sj.onc.1202983. PMID 10557092.
Holtrich U, Wolf G, Yuan J, et al. (2000). "Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages". Oncogene. 19 (42): 4832–9. doi:10.1038/sj.onc.1203845. PMID 11039900.
Liby K, Wu H, Ouyang B, et al. (2002). "Identification of the human homologue of the early-growth response gene Snk, encoding a serum-inducible kinase". DNA Seq. 11 (6): 527–33. doi:10.3109/10425170109041337. PMID 11696980. S2CID 46552280.
Shimizu-Yoshida Y, Sugiyama K, Rogounovitch T, et al. (2002). "Radiation-inducible hSNK gene is transcriptionally regulated by p53 binding homology element in human thyroid cells". Biochem. Biophys. Res. Commun. 289 (2): 491–8. doi:10.1006/bbrc.2001.5993. PMID 11716500.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ma S, Liu MA, Yuan YL, Erikson RL (2003). "The serum-inducible protein kinase Snk is a G1 phase polo-like kinase that is inhibited by the calcium- and integrin-binding protein CIB". Mol. Cancer Res. 1 (5): 376–84. PMID 12651910.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Burns TF, Fei P, Scata KA, et al. (2003). "Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells". Mol. Cell. Biol. 23 (16): 5556–71. doi:10.1128/MCB.23.16.5556-5571.2003. PMC 166320. PMID 12897130.
Ma S, Charron J, Erikson RL (2003). "Role of Plk2 (Snk) in mouse development and cell proliferation". Mol. Cell. Biol. 23 (19): 6936–43. doi:10.1128/MCB.23.19.6936-6943.2003. PMC 193943. PMID 12972611.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yogosawa S, Hatakeyama S, Nakayama KI, et al. (2006). "Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase". J. Biol. Chem. 280 (50): 41619–27. doi:10.1074/jbc.M508397200. PMID 16203730.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Park YY, Kim SH, Kim YJ, et al. (2007). "Polo-like kinase 2 gene expression is regulated by the orphan nuclear receptor estrogen receptor-related receptor gamma (ERRgamma)". Biochem. Biophys. Res. Commun. 362 (1): 107–13. doi:10.1016/j.bbrc.2007.07.170. PMID 17706602.
Matthew EM, Yen TJ, Dicker DT, et al. (2007). "Replication stress, defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells". Cell Cycle. 6 (20): 2571–8. doi:10.4161/cc.6.20.5079. PMID 17912033.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145632 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021701 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PLK2 polo-like kinase 2 (Drosophila)".

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

PLK2

References

Further reading