RPS6KA5

RPS6KA5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1VZO, 3KN5, 3KN6
Identifiers
Aliases	RPS6KA5, MSK1, MSPK1, RLPK, ribosomal protein S6 kinase A5
External IDs	OMIM: 603607 MGI: 1920336 HomoloGene: 48302 GeneCards: RPS6KA5
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	91,060,641 bp[1]
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)[2]
End	100,726,983 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• transferase activity; • protein kinase activity; • nucleotide binding; • metal ion binding; • kinase activity; • GO:0001948 protein binding; • ATP binding; • magnesium ion binding; • protein serine/threonine kinase activity;
Cellular component	• cytoplasm; • nucleoplasm; • cell nucleus;
Biological process	• GO:0007243 intracellular signal transduction; • regulation of transcription, DNA-templated; • epidermal growth factor receptor signaling pathway; • phosphorylation; • histone H3-S10 phosphorylation; • stimulatory C-type lectin receptor signaling pathway; • axon guidance; • positive regulation of histone acetylation; • interleukin-1-mediated signaling pathway; • protein phosphorylation; • histone phosphorylation; • positive regulation of CREB transcription factor activity; • positive regulation of histone phosphorylation; • positive regulation of NF-kappaB transcription factor activity; • histone H2A-S1 phosphorylation; • inflammatory response; • negative regulation of transcription, DNA-templated; • negative regulation of cytokine production; • positive regulation of transcription from RNA polymerase II promoter; • histone H3-S28 phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	9252
	73086
	ENSG00000100784
	ENSMUSG00000021180
	O75582
	Q8C050
NM_004755; NM_182398; NM_001322227; NM_001322228; NM_001322229;
	NM_001322230; NM_001322231; NM_001322232; NM_001322233; NM_001322234; NM_001322235; NM_001322236; NM_001322237; NM_001322238
	NM_153587; NM_001330702
NP_001309156; NP_001309157; NP_001309158; NP_001309159; NP_001309160;
	NP_001309161; NP_001309162; NP_001309163; NP_001309164; NP_001309165; NP_001309166; NP_001309167; NP_004746; NP_872198
	NP_001317631; NP_705815
	Wikidata
View/Edit Human	View/Edit Mouse

Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene.[5][6][7] This kinase, together with RPS6KA4, are thought to mediate the phosphorylation of histone H3, linked to the expression of immediate early genes.[8][9]

Interactions

RPS6KA5 has been shown to interact with CREB1.[5][10]

References

GRCh38: Ensembl release 89: ENSG00000100784 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021180 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Deak M, Clifton AD, Lucocq LM, Alessi DR (September 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J. 17 (15): 4426–41. doi:10.1093/emboj/17.15.4426. PMC 1170775. PMID 9687510.
Jiang C, Yu L, Tu Q, Zhao Y, Zhang H, Zhao S (April 2000). "Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31→q32.1 by radiation hybrid mapping". Cytogenet Cell Genet. 87 (3–4): 261–2. doi:10.1159/000015441. PMID 10702687.
"Entrez Gene: RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5".
Soloaga, Ana; Thomson, Stuart; Wiggin, Giselle R.; Rampersaud, Navita; Dyson, Mark H.; Hazzalin, Catherine A.; Mahadevan, Louis C.; Arthur, J.Simon C. (2003-06-02). "MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14". The EMBO Journal. 22 (11): 2788–2797. doi:10.1093/emboj/cdg273. ISSN 0261-4189. PMC 156769. PMID 12773393.
Reul, Johannes M. H. M.; Chandramohan, Yalini (2007-08-01). "Epigenetic mechanisms in stress-related memory formation". Psychoneuroendocrinology. Integrative approaches to neural plasticity (Lille Summer School, 2006). 32: S21–S25. doi:10.1016/j.psyneuen.2007.03.016. ISSN 0306-4530.
Wang, X; Li W; Williams M; Terada N; Alessi D R; Proud C G (August 2001). "Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase". EMBO J. 20 (16): 4370–9. doi:10.1093/emboj/20.16.4370. ISSN 0261-4189. PMC 125559. PMID 11500364.

Chung J, Uchida E, Grammer TC, Blenis J (1997). "STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation". Mol. Cell. Biol. 17 (11): 6508–16. doi:10.1128/MCB.17.11.6508. PMC 232504. PMID 9343414.
Jain N, Zhang T, Fong SL, et al. (1999). "Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK)". Oncogene. 17 (24): 3157–67. doi:10.1038/sj.onc.1202238. PMID 9872331.
New L, Zhao M, Li Y, et al. (1999). "Cloning and characterization of RLPK, a novel RSK-related protein kinase". J. Biol. Chem. 274 (2): 1026–32. doi:10.1074/jbc.274.2.1026. PMID 9873047.
Thomson S, Clayton AL, Hazzalin CA, et al. (1999). "The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase". EMBO J. 18 (17): 4779–93. doi:10.1093/emboj/18.17.4779. PMC 1171550. PMID 10469656.
Lim CP, Cao X (1999). "Serine phosphorylation and negative regulation of Stat3 by JNK". J. Biol. Chem. 274 (43): 31055–61. doi:10.1074/jbc.274.43.31055. PMID 10521505.
Buck M, Poli V, van der Geer P, et al. (2000). "Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha". Mol. Cell. 4 (6): 1087–92. doi:10.1016/S1097-2765(00)80237-3. PMID 10635333.
Lizcano JM, Morrice N, Cohen P (2001). "Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155". Biochem. J. 349 (Pt 2): 547–57. doi:10.1042/0264-6021:3490547. PMC 1221178. PMID 10880354.
Hefner Y, Borsch-Haubold AG, Murakami M, et al. (2001). "Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases". J. Biol. Chem. 275 (48): 37542–51. doi:10.1074/jbc.M003395200. PMID 10978317.
Arthur JS, Cohen P (2000). "MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells". FEBS Lett. 482 (1–2): 44–8. doi:10.1016/S0014-5793(00)02031-7. PMID 11018520.
Sapkota GP, Kieloch A, Lizcano JM, et al. (2001). "Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth". J. Biol. Chem. 276 (22): 19469–82. doi:10.1074/jbc.M009953200. PMID 11297520.
Deb A, Zamanian-Daryoush M, Xu Z, et al. (2001). "Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3". EMBO J. 20 (10): 2487–96. doi:10.1093/emboj/20.10.2487. PMC 125453. PMID 11350938.
Liu G, Zhang Y, Bode AM, et al. (2002). "Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation". J. Biol. Chem. 277 (11): 8810–6. doi:10.1074/jbc.M110477200. PMID 11777913.
Wiggin GR, Soloaga A, Foster JM, et al. (2002). "MSK1 and MSK2 Are Required for the Mitogen- and Stress-Induced Phosphorylation of CREB and ATF1 in Fibroblasts". Mol. Cell. Biol. 22 (8): 2871–81. doi:10.1128/MCB.22.8.2871-2881.2002. PMC 133730. PMID 11909979.
Markou T, Lazou A (2002). "Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase". Biochem. J. 365 (Pt 3): 757–63. doi:10.1042/BJ20011828. PMC 1222733. PMID 11994045.
Toska K, Kleppe R, Armstrong CG, et al. (2002). "Regulation of tyrosine hydroxylase by stress-activated protein kinases". J. Neurochem. 83 (4): 775–83. doi:10.1046/j.1471-4159.2002.01172.x. PMID 12421349.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Janknecht R (2003). "Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1)". Oncogene. 22 (5): 746–55. doi:10.1038/sj.onc.1206185. PMID 12569367.
Dolled-Filhart M, Camp RL, Kowalski DP, et al. (2003). "Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis". Clin. Cancer Res. 9 (2): 594–600. PMID 12576423.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100784 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021180 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9687510-5] Deak M, Clifton AD, Lucocq LM, Alessi DR (September 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J. 17 (15): 4426–41. doi:10.1093/emboj/17.15.4426. PMC 1170775. PMID 9687510.

[pmid10702687-6] Jiang C, Yu L, Tu Q, Zhao Y, Zhang H, Zhao S (April 2000). "Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31→q32.1 by radiation hybrid mapping". Cytogenet Cell Genet. 87 (3–4): 261–2. doi:10.1159/000015441. PMID 10702687.

[entrez-7] "Entrez Gene: RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5".

[8] Soloaga, Ana; Thomson, Stuart; Wiggin, Giselle R.; Rampersaud, Navita; Dyson, Mark H.; Hazzalin, Catherine A.; Mahadevan, Louis C.; Arthur, J.Simon C. (2003-06-02). "MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14". The EMBO Journal. 22 (11): 2788–2797. doi:10.1093/emboj/cdg273. ISSN 0261-4189. PMC 156769. PMID 12773393.

[9] Reul, Johannes M. H. M.; Chandramohan, Yalini (2007-08-01). "Epigenetic mechanisms in stress-related memory formation". Psychoneuroendocrinology. Integrative approaches to neural plasticity (Lille Summer School, 2006). 32: S21–S25. doi:10.1016/j.psyneuen.2007.03.016. ISSN 0306-4530.

[pmid11500364-10] Wang, X; Li W; Williams M; Terada N; Alessi D R; Proud C G (August 2001). "Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase". EMBO J. 20 (16): 4370–9. doi:10.1093/emboj/20.16.4370. ISSN 0261-4189. PMC 125559. PMID 11500364.

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

RPS6KA5

Interactions

References

Further reading