PFTK1

CDK14
Identifiers
Aliases	CDK14, PFTAIRE1, PFTK1, cyclin-dependent kinase 14, cyclin dependent kinase 14
External IDs	OMIM: 610679 MGI: 894318 HomoloGene: 7888 GeneCards: CDK14
Gene location (Human)
Chr.	Chromosome 7 (human)[1]
End	91,210,590 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	5,420,312 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• transferase activity; • nucleotide binding; • protein kinase activity; • cyclin-dependent protein serine/threonine kinase activity; • kinase activity; • protein serine/threonine kinase activity; • GO:0001948 protein binding; • ATP binding; • cyclin binding;
Cellular component	• membrane; • cell membrane; • cytoplasmic cyclin-dependent protein kinase holoenzyme complex; • cell nucleus; • cytoplasm; • cytosol;
Biological process	• phosphorylation; • regulation of canonical Wnt signaling pathway; • Wnt signaling pathway; • cell division; • protein phosphorylation; • G2/M transition of mitotic cell cycle; • cell cycle; • regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	5218
	18647
	ENSG00000058091
	ENSMUSG00000028926
	O94921
	O35495
	NM_001287135; NM_001287136; NM_001287137; NM_012395
	NM_011074; NM_001310448
	NP_001274064; NP_001274065; NP_001274066; NP_036527
	NP_001297377; NP_035204
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase PFTAIRE-1 is an enzyme that in humans is encoded by the PFTK1 gene.[5][6][7]

Interactions

PFTK1 has been shown to interact with SEPT8.[8]

References

GRCh38: Ensembl release 89: ENSG00000058091 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028926 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lazzaro MA, Albert PR, Julien JP (Jul 1997). "A novel cdc2-related protein kinase expressed in the nervous system". J Neurochem. 69 (1): 348–64. doi:10.1046/j.1471-4159.1997.69010348.x. PMID 9202329. S2CID 41686721.
Yang T, Chen JY (Apr 2001). "Identification and cellular localization of human PFTAIRE1". Gene. 267 (2): 165–72. doi:10.1016/S0378-1119(01)00391-2. PMID 11313143.
"Entrez Gene: PFTK1 PFTAIRE protein kinase 1".
Yang, Tao; Gao Yan-Kun; Chen Jiang-Ye (Jul 2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. China. 34 (4): 520–5. ISSN 0582-9879. PMID 12098780.

Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
Yang T, Gao YK, Chen JY (2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 34 (4): 520–5. PMID 12098780.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Gao Y, Jiang M, Yang T, et al. (2006). "A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins". Cell Res. 16 (6): 539–47. doi:10.1038/sj.cr.7310071. PMID 16775625.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Shu F, Lv S, Qin Y, et al. (2007). "Functional characterization of human PFTK1 as a cyclin-dependent kinase". Proc. Natl. Acad. Sci. U.S.A. 104 (22): 9248–53. Bibcode:2007PNAS..104.9248S. doi:10.1073/pnas.0703327104. PMC 1890480. PMID 17517622.
Denoeud F, Kapranov P, Ucla C, et al. (2007). "Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions". Genome Res. 17 (6): 746–59. doi:10.1101/gr.5660607. PMC 1891335. PMID 17567994.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000058091 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028926 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9202329-5] Lazzaro MA, Albert PR, Julien JP (Jul 1997). "A novel cdc2-related protein kinase expressed in the nervous system". J Neurochem. 69 (1): 348–64. doi:10.1046/j.1471-4159.1997.69010348.x. PMID 9202329. S2CID 41686721.

[pmid11313143-6] Yang T, Chen JY (Apr 2001). "Identification and cellular localization of human PFTAIRE1". Gene. 267 (2): 165–72. doi:10.1016/S0378-1119(01)00391-2. PMID 11313143.

[entrez-7] "Entrez Gene: PFTK1 PFTAIRE protein kinase 1".

[pmid12098780-8] Yang, Tao; Gao Yan-Kun; Chen Jiang-Ye (Jul 2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. China. 34 (4): 520–5. ISSN 0582-9879. PMID 12098780.

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

PFTK1

Interactions

References

Further reading