MAPK13

Mitogen-activated protein kinase 13 (MAPK 13), also known as stress-activated protein kinase 4 (SAPK4), is an enzyme that in humans is encoded by the MAPK13 gene.[5]

MAPK13
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMAPK13, MAPK 13, MAPK-13, PRKM13, SAPK4, p38delta, mitogen-activated protein kinase 13
External IDsOMIM: 602899 MGI: 1346864 HomoloGene: 48133 GeneCards: MAPK13
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p21.31Start36,127,809 bp[1]
End36,144,524 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

5603

26415

Ensembl

ENSG00000156711

ENSMUSG00000004864

UniProt

O15264

Q9Z1B7

RefSeq (mRNA)

NM_002754

NM_011950

RefSeq (protein)

NP_002745

NP_036080

Location (UCSC)Chr 6: 36.13 – 36.14 MbChr 17: 28.77 – 28.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000156711 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000004864 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: mitogen-activated protein kinase 13".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.