PIK3R4

PIK3R4
Identifiers
Aliases	PIK3R4, VPS15, p150, phosphoinositide-3-kinase regulatory subunit 4
External IDs	OMIM: 602610 MGI: 1922919 HomoloGene: 24678 GeneCards: PIK3R4
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	130,746,829 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	105,687,657 bp[2]
Gene ontology
Molecular function	• transferase activity; • protein kinase activity; • nucleotide binding; • kinase activity; • protein serine/threonine kinase activity; • GO:0001948 protein binding; • ATP binding; • 1-phosphatidylinositol-3-kinase activity;
Cellular component	• cytosol; • endosome; • late endosome; • phagocytic vesicle membrane; • membrane; • phosphatidylinositol 3-kinase complex, class III; • nuclear pore; • autophagosome; • phosphatidylinositol 3-kinase complex, class III, type I; • GO:0035085 axoneme; • nucleus-vacuole junction; • cytoplasmic vesicle; • phosphatidylinositol 3-kinase complex, class III, type II; • microtubule cytoskeleton; • intracellular membrane-bounded organelle;
Biological process	• cellular response to glucose starvation; • regulation of cytokinesis; • phosphorylation; • late endosome to vacuole transport; • autophagy of peroxisome; • receptor catabolic process; • positive regulation of phosphatidylinositol 3-kinase activity; • protein phosphorylation; • phosphatidylinositol biosynthetic process; • protein targeting to vacuole; • toll-like receptor 9 signaling pathway; • macroautophagy; • phosphatidylinositol-3-phosphate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	30849
	75669
	ENSG00000196455
	ENSMUSG00000032571
	Q99570
	Q8VD65
	NM_014602
	NM_001081309; NM_029380
	NP_055417
	NP_001074778
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphoinositide 3-kinase regulatory subunit 4, also known as PI3-kinase regulatory subunit 4 or PI3-kinase p150 subunit or phosphoinositide 3-kinase adaptor protein, or VPS15 is an enzyme that in humans is encoded by the PIK3R4 gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000196455 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000032571 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 [ Homo sapiens (human) ]".
Panaretou C, Domin J, Cockcroft S, Waterfield MD (January 1997). "Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex". J. Biol. Chem. 272 (4): 2477–85. doi:10.1074/jbc.272.4.2477. PMID 8999962.

Askham JM, Vaughan KT, Goodson HV, Morrison EE (2002). "Evidence That an Interaction between EB1 and p150Glued Is Required for the Formation and Maintenance of a Radial Microtubule Array Anchored at the Centrosome". Mol. Biol. Cell. 13 (10): 3627–45. doi:10.1091/mbc.E02-01-0061. PMC 129971. PMID 12388762.
Koyasu S (2003). "The role of PI3K in immune cells". Nat. Immunol. 4 (4): 313–9. doi:10.1038/ni0403-313. PMID 12660731. S2CID 9951653.
Matsunaga K, Saitoh T, Tabata K, et al. (2009). "Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages". Nat. Cell Biol. 11 (4): 385–96. doi:10.1038/ncb1846. PMID 19270696. S2CID 205286778.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Takeshita F, Gursel I, Ishii KJ, et al. (2004). "Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9". Semin. Immunol. 16 (1): 17–22. doi:10.1016/j.smim.2003.10.009. PMID 14751759.
Ligon LA, Shelly SS, Tokito M, Holzbaur EL (2003). "The Microtubule Plus-End Proteins EB1 and Dynactin Have Differential Effects on Microtubule Polymerization". Mol. Biol. Cell. 14 (4): 1405–17. doi:10.1091/mbc.E02-03-0155. PMC 153110. PMID 12686597.
Yan Y, Flinn RJ, Wu H, et al. (2009). "hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells". Biochem. J. 417 (3): 747–55. doi:10.1042/BJ20081865. PMC 2652830. PMID 18957027.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196455 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032571 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 [ Homo sapiens (human) ]".

[pmid8999962-6] Panaretou C, Domin J, Cockcroft S, Waterfield MD (January 1997). "Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex". J. Biol. Chem. 272 (4): 2477–85. doi:10.1074/jbc.272.4.2477. PMID 8999962.

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

PIK3R4

References

Further reading