Bay R 1531

Bay R 1531
Identifiers
	IUPAC name 1,3,4,5-tetrahydro-6-methoxy-N,N-dipropyl-benz[cd]indol-4-amine;
CAS Number	98770-54-8;
PubChem CID	127153;
ChemSpider	112872;
CompTox Dashboard (EPA)	DTXSID80913088 ;
Chemical and physical data
Formula	C18H28N2O
Molar mass	288.435 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COc2ccc1[nH]cc3CC(Cc2c13)N(CCC)CCC;
	InChI InChI=1S/C18H26N2O/c1-4-8-20(9-5-2)14-10-13-12-19-16-6-7-17(21-3)15(11-14)18(13)16/h6-7,12,14,19H,4-5,8-11H2,1-3H3; Key:BMZWFSGTPJUKJR-UHFFFAOYSA-N;

Bay R 1531 is a tricyclic tryptamine derivative which acts as a selective serotonin receptor 5-HT_1A agonist. It was researched unsuccessfully for the treatment of stroke but remains in use for scientific research.[1][2][3][4]

References

Bielenberg GW, Burkhardt M (December 1990). "5-hydroxytryptamine1A agonists. A new therapeutic principle for stroke treatment". Stroke. 21 (12 Suppl): IV161-3. PMID 2148035.
Critchley MA, Njung'e K, Handley SL (1992). "Actions and some interactions of 5-HT1A ligands in the elevated X-maze and effects of dorsal raphe lesions". Psychopharmacology. 106 (4): 484–90. doi:10.1007/bf02244819. PMID 1533721. S2CID 8404850.
Canto de Souza A, Nunes de Souza RL, Péla IR, Graeff FG (March 1997). "High intensity social conflict in the Swiss albino mouse induces analgesia modulated by 5-HT1A receptors". Pharmacology, Biochemistry, and Behavior. 56 (3): 481–6. doi:10.1016/s0091-3057(96)00246-8. PMID 9077586. S2CID 20078255.
Canto-de-Souza A, Nunes de Souza RL, Pelá IR, Graeff FG (March 1998). "Involvement of the midbrain periaqueductal gray 5-HT1A receptors in social conflict induced analgesia in mice". European Journal of Pharmacology. 345 (3): 253–6. doi:10.1016/s0014-2999(98)00018-1. PMID 9592023.

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[1] Bielenberg GW, Burkhardt M (December 1990). "5-hydroxytryptamine1A agonists. A new therapeutic principle for stroke treatment". Stroke. 21 (12 Suppl): IV161-3. PMID 2148035.

[2] Critchley MA, Njung'e K, Handley SL (1992). "Actions and some interactions of 5-HT1A ligands in the elevated X-maze and effects of dorsal raphe lesions". Psychopharmacology. 106 (4): 484–90. doi:10.1007/bf02244819. PMID 1533721. S2CID 8404850.

[3] Canto de Souza A, Nunes de Souza RL, Péla IR, Graeff FG (March 1997). "High intensity social conflict in the Swiss albino mouse induces analgesia modulated by 5-HT1A receptors". Pharmacology, Biochemistry, and Behavior. 56 (3): 481–6. doi:10.1016/s0091-3057(96)00246-8. PMID 9077586. S2CID 20078255.

[4] Canto-de-Souza A, Nunes de Souza RL, Pelá IR, Graeff FG (March 1998). "Involvement of the midbrain periaqueductal gray 5-HT1A receptors in social conflict induced analgesia in mice". European Journal of Pharmacology. 345 (3): 253–6. doi:10.1016/s0014-2999(98)00018-1. PMID 9592023.

Bay R 1531

See also

References