MIN-117

MIN-117 (known formerly as WF-516) is an investigational antidepressant which is under development by Minerva Neurosciences for the clinical treatment of major depressive disorder (MDD).[2][3][4] It is described as a 5-HT1A and 5-HT2A receptor antagonist and inhibitor of serotonin and dopamine reuptake,[4][5][6] and is also reported to possess affinity for the α1A- and α1B-adrenergic receptors.[4][6] As of May 2015, MIN-117 is in phase II clinical trials for MDD.[3] In December 2019, Minerva announced that MIN-117 was no longer in clinical development for MDD after disappointing results in a phase IIb trial.[7]

MIN-117
Clinical data
Other namesWF-516
Identifiers
PubChem CID
ChemSpider
Chemical and physical data
FormulaC25H25Cl2N3O
Molar mass454.40 g·mol−1
3D model (JSmol)

See also

References
  1. Saijo T, Maeda J, Okauchi T, Maeda J, Morio Y, Kuwahara Y, et al. (2012). "Presynaptic selectivity of a ligand for serotonin 1A receptors revealed by in vivo PET assays of rat brain". PLOS ONE. 7 (8): e42589. Bibcode:2012PLoSO...742589S. doi:10.1371/journal.pone.0042589. PMC 3413639. PMID 22880045.
  2. "Minerva Neuroscience". Retrieved 2015-05-19.
  3. Minerva Neurosciences (2015). "Minerva Neurosciences Reports First Quarter 2015 Financial Results and Other Key Business Updates". GlobalNewswire. Retrieved 2015-05-19.
  4. Minerva Neurosciences. "Investor Presentation March 2015" (PDF). Archived from the original (PDF) on 2015-05-20. Retrieved 2015-05-19.
  5. "Company Profile for Minerva Neurosciences Inc". Reuters. Retrieved 2015-05-19.
  6. Dion D (2014). "Some Nerves Surrounding Minerva Neurosciences IPO". Seeking Alpha. Retrieved 2015-05-19.
  7. "Minerva Neurosciences Reports Topline Results From Phase 2b Trial of MIN-117 in Major Depressive Disorder". BioSpace. Retrieved 2020-07-28.
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