Alpha-1B adrenergic receptor

The alpha-1B adrenergic receptor1B adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.[5]

ADRA1B
Identifiers
AliasesADRA1B, ADRA1, ALPHA1BAR, adrenoceptor alpha 1B
External IDsOMIM: 104220 MGI: 104774 HomoloGene: 55477 GeneCards: ADRA1B
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q33.3Start159,865,080 bp[1]
End159,973,012 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

147

11548

Ensembl

ENSG00000170214

ENSMUSG00000050541

UniProt

P35368

P97717

RefSeq (mRNA)

NM_000679

NM_001284380
NM_001284381
NM_007416

RefSeq (protein)

NP_000670

n/a

Location (UCSC)Chr 5: 159.87 – 159.97 MbChr 11: 43.77 – 43.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Receptor

There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.

Gene

This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.[5]

Ligands

Antagonists

Interactions

Alpha-1B adrenergic receptor has been shown to interact with AP2M1.[7] A role in regulation of dopaminergic neurotransmission has also been suggested.[8][9]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000170214 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000050541 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: ADRA1B adrenergic, alpha-1B-, receptor".
  6. Mizusawa H, Hedlund P, Sjunnesson J, Brioni JD, Sullivan JP, Andersson KE (2002). "Enhancement of apomorphine-induced penile erection in the rat by a selective alpha(1D)-adrenoceptor antagonist". Br. J. Pharmacol. 136 (5): 701–8. doi:10.1038/sj.bjp.0704773. PMC 1573401. PMID 12086979.
  7. Diviani D, Lattion AL, Abuin L, Staub O, Cotecchia S (May 2003). "The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis". J. Biol. Chem. 278 (21): 19331–40. doi:10.1074/jbc.M302110200. PMID 12644451.
  8. Drouin C, Darracq L, Trovero F, Blanc G, Glowinski J, Cotecchia S, Tassin JP (April 2002). "Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates". J. Neurosci. 22 (7): 2873–84. doi:10.1523/jneurosci.22-07-02873.2002. PMC 6758308. PMID 11923452.
  9. Auclair A, Drouin C, Cotecchia S, Glowinski J, Tassin JP (December 2004). "5-HT2A and alpha1b-adrenergic receptors entirely mediate dopamine release, locomotor response and behavioural sensitization to opiates and psychostimulants". Eur. J. Neurosci. 20 (11): 3073–84. doi:10.1111/j.1460-9568.2004.03805.x. PMID 15579162. S2CID 25138763.

Further reading


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