CELSR2

Cadherin EGF LAG seven-pass G-type receptor 2 is a protein that in humans is encoded by the CELSR2 gene.[5][6]

CELSR2
Identifiers
Aliases	CELSR2, CDHF10, EGFL2, Flamingo1, MEGF3, ADGRC2, cadherin EGF LAG seven-pass G-type receptor 2
External IDs	OMIM: 604265 MGI: 1858235 HomoloGene: 1078 GeneCards: CELSR2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 109,249,539 bp[1] End 109,275,751 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F3|3 47.02 cM Start 108,390,851 bp[2] End 108,415,552 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • calcium ion binding • transmembrane signaling receptor activity Cellular component • integral component of membrane • cell membrane • membrane • cytoplasm Biological process • homophilic cell adhesion via plasma membrane adhesion molecules • regulation of transcription, DNA-templated • cell surface receptor signaling pathway • multicellular organism development • regulation of cell-cell adhesion • Wnt signaling pathway, planar cell polarity pathway • G-protein coupled receptor signaling pathway • signal transduction • neural plate anterior/posterior regionalization • Wnt signaling pathway • cell adhesion • dendrite morphogenesis • cell-cell adhesion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1952	53883
Ensembl	ENSG00000143126	ENSMUSG00000068740
UniProt	Q9HCU4	Q9R0M0
RefSeq (mRNA)	NM_001408	NM_001004177 NM_017392
RefSeq (protein)	NP_001399	NP_001004177 NP_059088
Location (UCSC)	Chr 1: 109.25 – 109.28 Mb	Chr 3: 108.39 – 108.42 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.[6]