GPRC5B

G-protein coupled receptor family C group 5 member B is a protein that in humans is encoded by the GPRC5B gene.[5][6][7]

GPRC5B
Identifiers
AliasesGPRC5B, RAIG-2, RAIG2, G protein-coupled receptor class C group 5 member B
External IDsOMIM: 605948 MGI: 1927596 HomoloGene: 9435 GeneCards: GPRC5B
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16p12.3Start19,856,691 bp[1]
End19,886,167 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

51704

64297

Ensembl

ENSG00000167191

ENSMUSG00000008734

UniProt

Q9NZH0

Q923Z0

RefSeq (mRNA)

NM_001304771
NM_016235

NM_001195774
NM_022420

RefSeq (protein)

NP_001291700
NP_057319

NP_001182703
NP_071865

Location (UCSC)Chr 16: 19.86 – 19.89 MbChr 7: 118.97 – 119 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade.[7]

See also

References
  1. GRCh38: Ensembl release 89: ENSG00000167191 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000008734 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Nov 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
  6. Bräuner-Osborne H, Krogsgaard-Larsen P (Jul 2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain". Genomics. 65 (2): 121–8. doi:10.1006/geno.2000.6164. PMID 10783259.
  7. "Entrez Gene: GPRC5B G protein-coupled receptor, family C, group 5, member B".

Further reading
  • Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (2001). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)". Genomics. 67 (1): 8–18. doi:10.1006/geno.2000.6226. PMID 10945465.
  • "GPRC5 Receptors: RAIG2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

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