Secretin receptor

Human secretin receptor (gene name SCTR) is a G protein-coupled receptor which binds secretin and is the leading member (i.e., first cloned) of the class B GPCR subfamily.[5]

SCTR
Identifiers
AliasesSCTR, SR, secretin receptor
External IDsOMIM: 182098 MGI: 2441720 HomoloGene: 68290 GeneCards: SCTR
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q14.2Start119,439,843 bp[1]
End119,525,301 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6344

319229

Ensembl

ENSG00000080293

ENSMUSG00000026387

UniProt

P47872

Q5FWI2

RefSeq (mRNA)

NM_002980

NM_001012322
NM_001311077

RefSeq (protein)

NP_002971

NP_001012322
NP_001298006

Location (UCSC)Chr 2: 119.44 – 119.53 MbChr 1: 120.01 – 120.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

Secretin receptor has been shown to interact with pituitary adenylate cyclase activating peptide.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000080293 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026387 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dong M, Miller LJ (2002). "Molecular pharmacology of the secretin receptor". Receptors & Channels. 8 (3–4): 189–200. doi:10.1080/10606820213686. PMID 12529936.
  6. Felley CP, Qian JM, Mantey S, Pradhan T, Jensen RT (December 1992). "Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release". The American Journal of Physiology. 263 (6 Pt 1): G901-7. doi:10.1152/ajpgi.1992.263.6.G901. PMID 1335692.

Further reading

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