P2RY11

P2Y purinoceptor 11 is a protein that in humans is encoded by the P2RY11 gene.[3][4]i

P2RY11
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2B6S
Identifiers
Aliases	P2RY11, P2Y11, purinergic receptor P2Y11
External IDs	OMIM: 602697 HomoloGene: 130446 GeneCards: P2RY11
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 10,111,693 bp[1] End 10,115,372 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled receptor activity • G-protein coupled purinergic nucleotide receptor activity • signal transducer activity • ATP-activated adenosine receptor activity • neurotransmitter receptor activity • signaling receptor activity Cellular component • integral component of membrane • membrane • cell membrane • integral component of plasma membrane • intracellular Biological process • defense response • neuronal signal transduction • activation of adenylate cyclase activity • G-protein coupled purinergic nucleotide receptor signaling pathway • phospholipase C-activating G-protein coupled receptor signaling pathway • cellular response to ATP • calcium-mediated signaling • signal transduction • adenosine receptor signaling pathway • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5032	n/a
Ensembl	ENSG00000244165	n/a
UniProt	Q96G91	n/a
RefSeq (mRNA)	NM_002566	n/a
RefSeq (protein)	NP_002557	n/a
Location (UCSC)	Chr 19: 10.11 – 10.12 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

The product of this gene, P2Y₁₁, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occurring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product.[4]