Bombesin-like receptor 3

Function

Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin-like receptor-3 (BRS3; this article).[7][8]

BB3 is a G protein-coupled receptor.[6] BB3 only interacts with known naturally occurring bombesin-related peptides with low affinity and therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor.[6][9][10]

References

  1. GRCh38: Ensembl release 89: ENSG00000102239 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000031130 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Bombesin Receptors: BB3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
  6. Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF (March 1993). "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells". J. Biol. Chem. 268 (8): 5979–84. PMID 8383682.
  7. Ohki-Hamazaki H, Wada E, Matsui K, Wada K (July 1997). "Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse". Brain Res. 762 (1–2): 165–72. doi:10.1016/S0006-8993(97)00380-6. PMID 9262170. S2CID 1012779.
  8. "Entrez Gene: BRS3 bombesin-like receptor 3".
  9. Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH, Jensen RT (1997). "Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a uniquepharmacology compared with other mammalian bombesin receptors". J. Biol. Chem. 272 (41): 26062–26071. doi:10.1074/jbc.272.41.26062. PMID 9325344.
  10. Jensen RT, Battey JF, Spindel ER, Benya RV (2007). "International Union of Pharmacology: The Bombesin Receptors. Nomenclature, distribution, pharmacology, signaling and functions in normal and diseased states". Pharmacol. Rev. 60 (1): 1–42. doi:10.1124/pr.107.07108. PMC 2517428. PMID 18055507.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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