Neuromedin B receptor

NMBR
Identifiers
Aliases	NMBR, BB1, NMB-R, neuromedin B receptor, BB1R
External IDs	OMIM: 162341 MGI: 1100525 HomoloGene: 20560 GeneCards: NMBR
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	142,088,799 bp[1]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• G-protein coupled peptide receptor activity; • signal transducer activity; • G-protein coupled receptor activity; • bombesin receptor activity;
Cellular component	• integral component of plasma membrane; • membrane; • integral component of membrane; • cell membrane; • cytosol;
Biological process	• phospholipase C-activating G-protein coupled receptor signaling pathway; • bombesin receptor signaling pathway; • signal transduction; • G-protein coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4829
	18101
	ENSG00000135577
	ENSMUSG00000019865
	P28336
	O54799
	NM_002511; NM_001324307; NM_001324308
	NM_008703
	NP_001311236; NP_001311237; NP_002502
	NP_032729
	Wikidata
View/Edit Human	View/Edit Mouse

The neuromedin B receptor (NMBR), now known as BB₁ [4] is a G protein-coupled receptor whose endogenous ligand is neuromedin B.[5] In humans, this protein is encoded by the NMBR gene.

Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue.[6]

References

GRCh38: Ensembl release 89: ENSG00000135577 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Bombesin Receptors: BB₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Benya RV, Kusui T, Pradhan TK, Battey JF, Jensen RT (1995). "Expression and characterization of cloned human bombesin receptors". Mol. Pharmacol. 47 (1): 10–20. PMID 7838118.
"Entrez Gene: NMBR neuromedin B receptor".

"Bombesin Receptors: BB₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Receptors,+Bombesin at the US National Library of Medicine Medical Subject Headings (MeSH)

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