Brain-specific angiogenesis inhibitor 2

Brain-specific angiogenesis inhibitor 2 is a protein that in humans is encoded by the BAI2 gene.[5][6] It is a member of the adhesion-GPCR family of receptors.[7]

ADGRB2
Identifiers
AliasesADGRB2, BAI2, adhesion G protein-coupled receptor B2
External IDsOMIM: 602683 MGI: 2451244 HomoloGene: 1288 GeneCards: ADGRB2
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p35.2Start31,727,117 bp[1]
End31,764,893 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

576

230775

Ensembl

ENSG00000121753

ENSMUSG00000028782

UniProt

O60241

Q8CGM1

RefSeq (mRNA)

NM_001294335
NM_001294336
NM_001364857

RefSeq (protein)

NP_001281264
NP_001281265
NP_001351786

Location (UCSC)Chr 1: 31.73 – 31.76 MbChr 4: 129.98 – 130.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000121753 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028782 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenet Cell Genet. 79 (1–2): 103–8. doi:10.1159/000134693. PMID 9533023.
  6. "Entrez Gene: BAI2 brain-specific angiogenesis inhibitor 2".
  7. Stacey, edited by Simon Yona, Martin (2010). Adhesion-GPCRs : structure to function. New York: Springer Science+Business Media. ISBN 9781441979124.CS1 maint: extra text: authors list (link)

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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