FZD6

Frizzled-6 is a protein that in humans is encoded by the FZD6 gene.[4][5][6]

FZD6
Identifiers
AliasesFZD6, FZ-6, FZ6, HFZ6, NDNC10, frizzled class receptor 6, NDNC1
External IDsOMIM: 603409 MGI: 108474 HomoloGene: 2617 GeneCards: FZD6
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q22.3Start103,298,433 bp[1]
End103,332,866 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8323

14368

Ensembl

ENSG00000164930

ENSMUSG00000022297

UniProt

O60353

Q61089

RefSeq (mRNA)

NM_001164615
NM_001164616
NM_003506
NM_001317796

NM_001162494
NM_008056

RefSeq (protein)

NP_001155966
NP_032082

Location (UCSC)Chr 8: 103.3 – 103.33 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for WNT signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other FZD family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif.[6] The FZD6 protein is believed to be the receptor for the WNT4 ligand.[7]

Interactions

FZD6 has been shown to interact with Secreted frizzled-related protein 1.[8]

See also

Model organisms

Model organisms have been used in the study of FXYD3 function. In 2004, researchers at the Howard Hughes Medical Institute showed that FZD6 controls hair patterning in mice,[9] and its human homologue is understood to play a part in the formation of hair whorls and cowlicks. A conditional knockout mouse line called Fxyd3tm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[10] Male and female animals underwent a standardized phenotypic screen[11] to determine the effects of deletion.[12][13][14][15] Additional screens performed: - In-depth immunological phenotyping[16]

References
  1. GRCh38: Ensembl release 89: ENSG00000164930 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Tokuhara M, Hirai M, Atomi Y, Terada M, Katoh M (Feb 1998). "Molecular cloning of human Frizzled-6". Biochemical and Biophysical Research Communications. 243 (2): 622–7. doi:10.1006/bbrc.1998.8143. PMID 9480858.
  5. Golan T, Yaniv A, Bafico A, Liu G, Gazit A (Apr 2004). "The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade". The Journal of Biological Chemistry. 279 (15): 14879–88. doi:10.1074/jbc.M306421200. PMID 14747478.
  6. "Entrez Gene: FZD6 frizzled homolog 6 (Drosophila)".
  7. Lyons JP, Mueller UW, Ji H, Everett C, Fang X, Hsieh JC, Barth AM, McCrea PD (Aug 2004). "Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells". Experimental Cell Research. 298 (2): 369–87. doi:10.1016/j.yexcr.2004.04.036. PMID 15265686.
  8. Bafico A, Gazit A, Pramila T, Finch PW, Yaniv A, Aaronson SA (Jun 1999). "Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling". The Journal of Biological Chemistry. 274 (23): 16180–7. doi:10.1074/jbc.274.23.16180. PMID 10347172.
  9. "Frizzled6 controls hair patterning in mice".
  10. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  11. "International Mouse Phenotyping Consortium".
  12. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  13. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  14. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  15. White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  16. "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading
  • "Frizzled Receptors: FZD6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.